Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 5379207..5379871 Replicon chromosome
Accession NZ_AP022601
Organism Mycobacterium gallinarum strain JCM 6399

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N42_RS26600 Protein ID WP_163735088.1
Coordinates 5379461..5379871 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N42_RS26595 Protein ID WP_163735085.1
Coordinates 5379207..5379464 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N42_RS26565 5375152..5376612 + 1461 WP_174262175.1 amino acid ABC transporter substrate-binding protein/permease -
G6N42_RS26570 5376657..5377382 + 726 WP_174262298.1 amino acid ABC transporter ATP-binding protein -
G6N42_RS26575 5377474..5377659 - 186 WP_163735071.1 hypothetical protein -
G6N42_RS26580 5377652..5377978 - 327 WP_163735076.1 hypothetical protein -
G6N42_RS26585 5377995..5378207 - 213 WP_163735079.1 hypothetical protein -
G6N42_RS26590 5378438..5379163 + 726 WP_163735082.1 hypothetical protein -
G6N42_RS26595 5379207..5379464 + 258 WP_163735085.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N42_RS26600 5379461..5379871 + 411 WP_163735088.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N42_RS26605 5379951..5380637 - 687 WP_163738342.1 sensor domain-containing protein -
G6N42_RS26610 5380835..5382460 - 1626 WP_163735092.1 peptide chain release factor 3 -
G6N42_RS26615 5382823..5383596 + 774 WP_163735095.1 SseB family protein -
G6N42_RS26620 5383710..5384003 - 294 WP_163735097.1 hypothetical protein -
G6N42_RS26625 5384173..5384568 - 396 WP_163735099.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14518.66 Da        Isoelectric Point: 4.3857

>T36300 WP_163735088.1 NZ_AP022601:5379461-5379871 [Mycobacterium gallinarum]
VTTDQPAAGILDTSVFIADESGRQLETSLLPEELATTVVTLAELNAGVLAARTSEIRARRLRTLDAVADMIALPVDEEAA
QMWALLRVHLAEAGRRVRVNDLWIAAIAAAKRVPVVTQDGDFDVLEGVAGLAIIHV

Download         Length: 411 bp

>T36300 NZ_AP022601:5379461-5379871 [Mycobacterium gallinarum]
GTGACAACCGATCAGCCCGCCGCCGGCATCCTCGACACCTCGGTGTTCATCGCCGACGAGAGCGGGCGACAACTCGAGAC
ATCGCTGCTTCCTGAGGAACTCGCCACGACTGTGGTGACCCTGGCCGAACTGAACGCGGGTGTGCTCGCCGCGCGGACCT
CCGAGATCCGGGCGCGTCGCCTTCGCACATTGGACGCAGTCGCCGACATGATCGCGTTACCGGTCGACGAGGAGGCGGCT
CAAATGTGGGCGCTGTTACGCGTCCATCTGGCTGAGGCGGGGCGACGGGTCCGAGTCAATGACCTGTGGATCGCCGCAAT
TGCAGCCGCCAAGCGCGTGCCCGTGGTCACGCAGGATGGGGACTTCGATGTTCTAGAAGGCGTCGCGGGTCTCGCGATAA
TCCACGTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9418.59 Da        Isoelectric Point: 4.8537

>AT36300 WP_163735085.1 NZ_AP022601:5379207-5379464 [Mycobacterium gallinarum]
MSTVASRELRNDTAGVLRRVQAGEEVTITVNGRAVAMITAVQPRRRRWVSKAELVRRLETSQADPGLRDDLAELAGETTD
ELDEL

Download         Length: 258 bp

>AT36300 NZ_AP022601:5379207-5379464 [Mycobacterium gallinarum]
ATGTCAACAGTGGCGTCCCGTGAACTTCGAAACGACACGGCGGGCGTGCTGCGACGGGTCCAAGCGGGCGAAGAAGTCAC
GATCACGGTGAATGGGCGAGCCGTCGCGATGATCACCGCGGTGCAGCCCAGGCGTCGGCGGTGGGTGTCCAAGGCCGAAC
TGGTCAGGCGGCTCGAGACCAGCCAGGCGGACCCCGGCCTGCGTGACGACCTCGCAGAGCTCGCCGGTGAAACCACCGAC
GAACTCGACGAGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References