Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4713699..4714333 Replicon chromosome
Accession NZ_AP022599
Organism Mycolicibacterium pulveris strain JCM 6370

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N28_RS22845 Protein ID WP_170307943.1
Coordinates 4713699..4714079 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N28_RS22850 Protein ID WP_163904291.1
Coordinates 4714076..4714333 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N28_RS22820 4708745..4709851 - 1107 WP_163904279.1 amidohydrolase family protein -
G6N28_RS22825 4710663..4711040 + 378 WP_163904281.1 metalloregulator ArsR/SmtB family transcription factor -
G6N28_RS22830 4711037..4712158 + 1122 WP_163904283.1 ACR3 family arsenite efflux transporter -
G6N28_RS22835 4712151..4712819 + 669 WP_163904285.1 arsenate reductase ArsC -
G6N28_RS22840 4713099..4713356 + 258 WP_163904287.1 hypothetical protein -
G6N28_RS22845 4713699..4714079 - 381 WP_170307943.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N28_RS22850 4714076..4714333 - 258 WP_163904291.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N28_RS22855 4714526..4715308 + 783 WP_163904293.1 SDR family oxidoreductase -
G6N28_RS22860 4715446..4717122 + 1677 WP_179962232.1 GMC family oxidoreductase N-terminal domain-containing protein -
G6N28_RS22865 4717239..4718141 + 903 WP_163904296.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4668539..4728484 59945


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14029.29 Da        Isoelectric Point: 10.4121

>T36297 WP_170307943.1 NZ_AP022599:c4714079-4713699 [Mycolicibacterium pulveris]
VILVDSDILIAHLRGLEAARDWLIEARGEGPLAISVVSIAELVGGMRSVERREVWQLLASFRTEPATEIVARRAGHFRRR
YRASHPGIGLGDYLIAATADVKGYQPATLNVKHFPMFKNLRPPFTL

Download         Length: 381 bp

>T36297 NZ_AP022599:c4714079-4713699 [Mycolicibacterium pulveris]
GTGATCCTCGTCGACTCGGACATTCTCATCGCTCACCTTCGCGGTCTCGAAGCGGCCCGAGATTGGCTCATCGAAGCGAG
AGGGGAGGGACCGTTAGCGATCAGCGTGGTGTCGATTGCCGAGCTCGTCGGTGGGATGCGCAGCGTCGAGCGCCGCGAAG
TGTGGCAGCTACTAGCGTCATTTCGCACCGAACCAGCCACTGAGATCGTCGCGCGCCGCGCCGGCCACTTCAGGCGGCGA
TACCGGGCGAGTCATCCCGGCATTGGCCTTGGCGACTATCTGATCGCGGCGACTGCTGACGTGAAGGGCTATCAGCCAGC
GACGTTGAACGTCAAGCACTTCCCGATGTTCAAGAACCTGCGGCCGCCATTCACCCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9743.70 Da        Isoelectric Point: 4.5626

>AT36297 WP_163904291.1 NZ_AP022599:c4714333-4714076 [Mycolicibacterium pulveris]
MKRTNIYLDEEQTASLDKLAEQQGVSRAELIRQLLDRALNNADDNLESDLSAIEGSFGALRDVESPDRRPGSREEHLDRM
WRRSS

Download         Length: 258 bp

>AT36297 NZ_AP022599:c4714333-4714076 [Mycolicibacterium pulveris]
ATGAAGCGCACCAACATCTACCTCGACGAGGAGCAGACGGCCAGTCTCGACAAGTTGGCCGAACAGCAGGGCGTTTCGCG
TGCCGAGCTCATCCGCCAACTGCTAGACAGGGCGCTCAACAACGCCGACGACAATCTCGAATCTGACCTAAGTGCGATAG
AGGGGTCGTTCGGTGCGCTGCGCGATGTGGAATCGCCTGATCGTCGTCCCGGCAGCCGTGAGGAGCACCTCGACCGGATG
TGGCGCCGCAGTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References