Detailed information of TA system TA036296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3210365..3211000
• Replicon: chromosome
• Accession: NZ_AP022599
• Organism: Mycolicibacterium pulveris strain JCM 6370

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: G6N28_RS15600
• Protein ID: WP_163901735.1
• Coordinates: 3210557..3211000 (+)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: -
• Locus tag: G6N28_RS15595
• Protein ID: WP_163901733.1
• Coordinates: 3210365..3210553 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N28_RS15585	3206384..3207964	+	1581	WP_163901729.1	serine hydrolase	-
G6N28_RS15590	3207961..3210354	+	2394	WP_163901731.1	cation-translocating P-type ATPase	-
G6N28_RS15595	3210365..3210553	+	189	WP_163901733.1	antitoxin	Antitoxin
G6N28_RS15600	3210557..3211000	+	444	WP_163901735.1	SRPBCC family protein	Toxin
G6N28_RS15605	3211108..3211677	-	570	WP_163906293.1	isomerase	-
G6N28_RS15610	3211680..3212351	-	672	WP_163901737.1	NAD(P)H-binding protein	-
G6N28_RS15615	3212362..3213813	-	1452	WP_163901739.1	long-chain fatty acid--CoA ligase	-
G6N28_RS15620	3213818..3214591	-	774	WP_163901741.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-143)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 16058.78 Da
• Isoelectric Point: 10.2030

>T36296 WP_163901735.1 NZ_AP022599:3210557-3211000 [Mycolicibacterium pulveris]
MAKLSVSVDVPLPPEQAWQCASDLSRYREWLSIHRVWRSKLPETLEKGTTLESIVEVKGMPNRIKWTIVHFKPPEAMTLN
GDGKGGVKVKLIGKVKPAPNGTEASTVTFDVHLGGPALFGPIGMVVAGALRGDIRESLERFKLVFAA

Nucleotide

• Length: 444 bp

>T36296 NZ_AP022599:3210557-3211000 [Mycolicibacterium pulveris]
ATGGCGAAACTTTCTGTTTCCGTGGACGTTCCGCTGCCACCGGAGCAGGCTTGGCAGTGCGCATCTGATCTGTCCCGCTA
CCGGGAATGGTTGAGCATTCACCGGGTGTGGCGCAGCAAGCTGCCCGAGACGTTGGAGAAGGGCACCACGCTGGAATCCA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACCATCGTCCACTTCAAGCCGCCGGAGGCGATGACGCTCAAC
GGCGACGGCAAGGGCGGCGTCAAGGTCAAGCTGATCGGCAAGGTCAAACCCGCGCCGAACGGTACGGAGGCGTCGACGGT
GACGTTCGACGTGCACCTGGGCGGGCCTGCGCTGTTCGGCCCGATCGGCATGGTGGTGGCCGGCGCGCTGCGCGGCGACA
TCCGCGAGTCGCTCGAGCGGTTCAAGCTGGTGTTCGCCGCGTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6928.76 Da
• Isoelectric Point: 9.9662

>AT36296 WP_163901733.1 NZ_AP022599:3210365-3210553 [Mycolicibacterium pulveris]
MAFLDKVKNLLARNADKVDTAIDKAGDIVDQKTQGKYAQHVDKAQDTARKYVNKSNPQNPQN

Nucleotide

• Length: 189 bp

>AT36296 NZ_AP022599:3210365-3210553 [Mycolicibacterium pulveris]
ATGGCATTTCTCGACAAGGTGAAGAATCTGCTGGCCCGCAACGCGGACAAGGTGGACACCGCGATCGACAAGGCCGGTGA
CATCGTCGACCAGAAGACGCAGGGCAAGTACGCTCAGCACGTTGACAAGGCGCAGGACACCGCCAGGAAGTACGTCAACA
AGAGCAATCCGCAGAACCCGCAGAATTGA