Detailed information of TA system TA036295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): CapRel-ATcapRel/-
• Location: 3627438..3628429
• Replicon: chromosome
• Accession: NZ_AP022598
• Organism: Mycolicibacterium parafortuitum strain JCM 6367

Toxin (Protein)

• Gene name: capRel
• Uniprot ID: -
• Locus tag: NTM_RS17395
• Protein ID: WP_163766971.1
• Coordinates: 3627438..3628172 (+)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: ATcapRel
• Uniprot ID: -
• Locus tag: NTM_RS17400
• Protein ID: WP_163766972.1
• Coordinates: 3628169..3628429 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTM_RS17370	3622536..3625325	-	2790	WP_104865332.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
NTM_RS17375	3625509..3626087	+	579	WP_104865331.1	hypothetical protein	-
NTM_RS17380	3626193..3626618	+	426	WP_083146619.1	DUF3052 domain-containing protein	-
NTM_RS17385	3626650..3627120	+	471	WP_163766970.1	peroxiredoxin	-
NTM_RS17395	3627438..3628172	+	735	WP_163766971.1	RelA/SpoT domain-containing protein	Toxin
NTM_RS17400	3628169..3628429	+	261	WP_163766972.1	hypothetical protein	Antitoxin
NTM_RS17405	3628446..3629954	-	1509	WP_163766973.1	site-specific integrase	-
NTM_RS17410	3629999..3630304	+	306	WP_163766974.1	hypothetical protein	-
NTM_RS17415	3630313..3631485	-	1173	WP_163769529.1	hypothetical protein	-
NTM_RS17420	3631968..3632330	-	363	WP_163766975.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (79-177)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 26984.08 Da
• Isoelectric Point: 10.1770

>T36295 WP_163766971.1 NZ_AP022598:3627438-3628172 [Mycolicibacterium parafortuitum]
MAMQPADVPSVSAVNKAGDALRVLIGKSGALTSEEMNRAVHAIDVLVAWRAAHALPLATATMGLKSRVQTAGCADGSRVS
QRLKRIPTILSKLHREPKMELGRMHDIGGCRVVLADLAQVYEVLDRYRTRPTSGGIKVQDYIEKPKPDGYRGVHVIVKYH
GRRIEVQLRTQVQHEWAFTVESVTARYGLAIKTGGGPLPVREWFQTVSEAMAVEEHGGTVDDDLLRRVSTMREAAQPYLR
GERR

Nucleotide

• Length: 735 bp

>T36295 NZ_AP022598:3627438-3628172 [Mycolicibacterium parafortuitum]
ATGGCGATGCAGCCAGCCGATGTGCCGAGCGTCAGCGCGGTCAATAAGGCAGGTGACGCCCTGCGCGTACTCATCGGTAA
GAGCGGTGCGCTGACATCCGAGGAAATGAACCGCGCAGTTCACGCCATCGACGTCCTCGTTGCATGGAGGGCTGCACACG
CGCTGCCGCTGGCCACCGCCACCATGGGCCTGAAGTCCCGGGTGCAGACAGCGGGCTGTGCTGATGGCAGTCGGGTGTCG
CAGCGTCTCAAACGCATTCCAACGATTCTCAGCAAGCTGCACCGCGAGCCCAAGATGGAGCTCGGGCGAATGCATGACAT
CGGGGGATGCCGAGTGGTGCTCGCCGACCTGGCGCAGGTTTACGAGGTGCTTGACCGATACCGGACTCGTCCTACCAGCG
GCGGCATCAAGGTGCAGGACTACATAGAGAAGCCGAAACCCGACGGGTATCGCGGGGTGCACGTCATCGTGAAGTATCAC
GGCAGGCGGATCGAGGTGCAGCTCCGGACCCAGGTACAGCATGAATGGGCATTTACCGTGGAATCCGTCACTGCTCGATA
CGGGCTCGCCATCAAGACCGGCGGTGGTCCTCTACCAGTCAGGGAGTGGTTTCAAACGGTGTCTGAGGCGATGGCCGTGG
AAGAGCACGGTGGGACCGTTGATGATGACCTCTTGCGCCGGGTATCTACAATGAGGGAAGCTGCCCAACCATATCTGCGA
GGAGAACGCCGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9595.84 Da
• Isoelectric Point: 5.0944

>AT36295 WP_163766972.1 NZ_AP022598:3628169-3628429 [Mycolicibacterium parafortuitum]
MSATLKHFLLVFDHDRAELKDMREFGTDTKAAMAEYARLEREHLSEKGADSIEIVLIGSDSLDTVKVTHANYFDGTVAVS
KYFAGI

Nucleotide

• Length: 261 bp

>AT36295 NZ_AP022598:3628169-3628429 [Mycolicibacterium parafortuitum]
ATGAGTGCCACGCTCAAGCACTTCTTGCTGGTGTTCGACCATGACCGGGCCGAACTCAAGGACATGCGGGAATTCGGCAC
AGATACTAAGGCCGCGATGGCCGAGTACGCCCGCCTTGAGCGCGAGCACCTGAGCGAAAAGGGTGCCGACTCCATCGAGA
TCGTCCTTATTGGCTCGGACTCGCTGGACACTGTGAAGGTCACTCACGCCAATTACTTCGACGGAACCGTGGCCGTTTCG
AAGTACTTCGCGGGCATCTGA