Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2836183..2836745 Replicon chromosome
Accession NZ_AP022598
Organism Mycolicibacterium parafortuitum strain JCM 6367

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NTM_RS13680 Protein ID WP_104863999.1
Coordinates 2836377..2836745 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NTM_RS13675 Protein ID WP_104864225.1
Coordinates 2836183..2836380 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTM_RS13655 2831361..2833136 + 1776 WP_179964066.1 penicillin-binding protein -
NTM_RS13660 2833133..2834251 - 1119 WP_163766604.1 hypothetical protein -
NTM_RS13665 2834334..2835407 + 1074 WP_163766605.1 redox-regulated ATPase YchF -
NTM_RS13670 2835434..2836036 - 603 WP_163766606.1 class I SAM-dependent methyltransferase -
NTM_RS13675 2836183..2836380 + 198 WP_104864225.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NTM_RS13680 2836377..2836745 + 369 WP_104863999.1 type II toxin-antitoxin system VapC family toxin Toxin
NTM_RS13685 2836858..2837199 + 342 WP_104863998.1 DUF1801 domain-containing protein -
NTM_RS13690 2837400..2837759 + 360 WP_104864224.1 DUF1801 domain-containing protein -
NTM_RS13695 2837820..2838218 + 399 WP_163766607.1 VOC family protein -
NTM_RS13700 2838299..2838691 + 393 WP_163766608.1 ester cyclase -
NTM_RS13705 2838741..2839601 + 861 WP_163766609.1 DUF4344 domain-containing metallopeptidase -
NTM_RS13710 2839606..2840100 - 495 WP_163766610.1 nitroreductase family deazaflavin-dependent oxidoreductase -
NTM_RS13715 2840110..2840370 - 261 WP_104863993.1 hypothetical protein -
NTM_RS13720 2840443..2840745 - 303 WP_104863992.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.87 Da        Isoelectric Point: 5.1666

>T36294 WP_104863999.1 NZ_AP022598:2836377-2836745 [Mycolicibacterium parafortuitum]
MILVDTAVWIDHLHAGESRLVEQLEMDGVGCHPMVVEELALGSIARRNVVLDLLANLWQFPTARHDEILYLVEQRQLWGR
GLSAVDAHLMAAVSMVEGARLWTRDKRLKAASTEVGVRLFDE

Download         Length: 369 bp

>T36294 NZ_AP022598:2836377-2836745 [Mycolicibacterium parafortuitum]
ATGATTCTCGTAGACACCGCGGTGTGGATCGATCATCTTCACGCCGGGGAGTCCAGGCTGGTCGAGCAGTTGGAAATGGA
TGGTGTCGGCTGCCATCCGATGGTCGTCGAGGAGTTGGCGCTCGGATCAATTGCACGTCGGAACGTGGTGCTCGATCTTC
TCGCCAACCTGTGGCAGTTCCCGACCGCGCGACATGACGAGATCCTGTATCTCGTTGAGCAACGGCAACTCTGGGGGCGC
GGGCTGAGCGCTGTCGACGCCCATCTGATGGCCGCTGTCTCCATGGTTGAGGGCGCGCGCCTGTGGACCCGGGACAAGCG
ATTGAAGGCTGCTTCAACGGAAGTGGGCGTCCGACTGTTCGACGAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6871.79 Da        Isoelectric Point: 7.0117

>AT36294 WP_104864225.1 NZ_AP022598:2836183-2836380 [Mycolicibacterium parafortuitum]
MRTTVTIDDELLAKAAELTGVHESVALLRQGLQTLIRVESARRLAALGGSDAEATAAPRRRGASE

Download         Length: 198 bp

>AT36294 NZ_AP022598:2836183-2836380 [Mycolicibacterium parafortuitum]
ATGAGAACCACTGTCACCATCGACGACGAACTGCTCGCCAAAGCTGCCGAGTTGACCGGTGTGCACGAAAGTGTGGCACT
GCTCAGACAGGGATTGCAGACACTCATTCGGGTGGAAAGTGCGCGCCGTCTTGCGGCGCTGGGCGGATCGGATGCCGAGG
CGACTGCCGCGCCGCGGCGGCGTGGCGCATCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References