Detailed information of TA system TA036293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-AbrB
• Location: 507721..508377
• Replicon: chromosome
• Accession: NZ_AP022598
• Organism: Mycolicibacterium parafortuitum strain JCM 6367

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NTM_RS02320
• Protein ID: WP_170311962.1
• Coordinates: 507721..508131 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NTM_RS02325
• Protein ID: WP_013472822.1
• Coordinates: 508138..508377 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTM_RS02310	503790..504890	-	1101	WP_163765323.1	acyl-CoA desaturase	-
NTM_RS02315	505116..507641	+	2526	WP_163765324.1	SEC-C domain-containing protein	-
NTM_RS02320	507721..508131	-	411	WP_170311962.1	PIN domain-containing protein	Toxin
NTM_RS02325	508138..508377	-	240	WP_013472822.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
NTM_RS02330	508481..509614	-	1134	WP_163765325.1	hypothetical protein	-
NTM_RS02335	509712..509942	-	231	WP_163765326.1	hypothetical protein	-
NTM_RS02340	510243..512999	-	2757	WP_163765327.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	495178..553571	58393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-124)

Antitoxin

• SpoVT-AbrB domain (9-38)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14090.05 Da
• Isoelectric Point: 8.6021

>T36293 WP_170311962.1 NZ_AP022598:c508131-507721 [Mycolicibacterium parafortuitum]
MPVTAVDTSVAVPLLVGSHREHAAVAKWAKGKTLGLSGHALTETYSVLTRLPGDARLLPQDAVALIDANFTASLTLGARV
ARGAHRELARRGIGGGATYDGLVALAAREHDVALATRDARARATYEALGVDTEVVA

Nucleotide

• Length: 411 bp

>T36293 NZ_AP022598:c508131-507721 [Mycolicibacterium parafortuitum]
ATGCCTGTCACAGCGGTTGATACGAGTGTCGCTGTACCGCTGCTCGTCGGCTCCCACCGAGAACACGCCGCCGTGGCGAA
ATGGGCCAAAGGCAAGACACTGGGACTCAGCGGGCATGCGCTGACCGAGACGTACTCGGTGCTGACACGGCTACCCGGTG
ATGCGCGGCTGCTCCCGCAGGATGCGGTCGCACTGATCGACGCCAACTTCACTGCATCCCTCACGCTCGGCGCCCGGGTT
GCACGTGGTGCGCATCGCGAGTTGGCCCGACGAGGAATCGGCGGCGGTGCGACGTATGACGGACTCGTTGCGTTGGCGGC
GCGAGAACACGATGTGGCGCTGGCAACTCGGGATGCCCGCGCCAGGGCGACATATGAAGCCCTGGGTGTGGACACCGAAG
TTGTTGCGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8369.54 Da
• Isoelectric Point: 4.6750

>AT36293 WP_013472822.1 NZ_AP022598:c508377-508138 [Mycolicibacterium parafortuitum]
MEAVIDSGGRVVLPKQLRDALGLTPGTKVDISAYGGGLQIVPGGRTARLERDDDGRLVAQADTVVTDEMMFAIIDSGRR

Nucleotide

• Length: 240 bp

>AT36293 NZ_AP022598:c508377-508138 [Mycolicibacterium parafortuitum]
ATGGAGGCTGTGATCGATTCCGGTGGCCGAGTGGTCCTACCGAAGCAACTGCGGGACGCGCTGGGTTTGACCCCCGGCAC
GAAAGTAGACATTTCTGCCTACGGCGGTGGGTTACAGATCGTTCCGGGCGGGCGAACCGCTCGACTCGAACGCGACGACG
ATGGTCGCCTCGTGGCGCAAGCCGACACCGTGGTCACCGACGAGATGATGTTCGCCATCATCGACTCGGGTCGGCGCTGA