Detailed information of TA system TA036292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 494960..495591
• Replicon: chromosome
• Accession: NZ_AP022598
• Organism: Mycolicibacterium parafortuitum strain JCM 6367

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NTM_RS02275
• Protein ID: WP_163765316.1
• Coordinates: 495178..495591 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NTM_RS02270
• Protein ID: WP_083145609.1
• Coordinates: 494960..495187 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NTM_RS02250	490767..491693	-	927	WP_163765312.1	DUF732 domain-containing protein	-
NTM_RS02255	491708..492802	-	1095	WP_163765313.1	zinc ribbon domain-containing protein	-
NTM_RS02260	493355..493663	+	309	WP_163765314.1	DUF732 domain-containing protein	-
NTM_RS02265	493689..494840	-	1152	WP_163765315.1	CoA transferase	-
NTM_RS02270	494960..495187	+	228	WP_083145609.1	hypothetical protein	Antitoxin
NTM_RS02275	495178..495591	+	414	WP_163765316.1	PIN domain nuclease	Toxin
NTM_RS02280	495612..497339	-	1728	WP_163765317.1	VanW family protein	-
NTM_RS02285	497531..498454	+	924	WP_163765318.1	ribonuclease H	-
NTM_RS02290	498463..499452	+	990	WP_163765319.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (17-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15199.51 Da
• Isoelectric Point: 4.7352

>T36292 WP_163765316.1 NZ_AP022598:495178-495591 [Mycolicibacterium parafortuitum]
VAVRPWLIDKSAYTRLADSPDVDAWMQRIERGLVRISTVTRLEIGYSFRTAAEAHSEVMSPPLVLMPIEYLTPAIEDRAR
EIQLNLADRGQHRAPSIPDLLIAATAEMSGLTVLSVDKDFSLIADITGQPIETLRMA

Nucleotide

• Length: 414 bp

>T36292 NZ_AP022598:495178-495591 [Mycolicibacterium parafortuitum]
GTGGCGGTGAGGCCATGGCTGATCGATAAGTCGGCGTACACGCGGCTCGCGGACTCACCCGACGTCGATGCCTGGATGCA
GCGCATCGAACGCGGACTGGTCCGCATCAGCACGGTGACCCGCCTCGAAATTGGCTATTCGTTCCGCACAGCAGCGGAGG
CGCACTCCGAAGTGATGTCGCCGCCCTTGGTGCTCATGCCGATCGAGTACCTCACGCCGGCCATCGAGGATCGCGCCCGC
GAGATACAACTCAACTTGGCTGACCGCGGACAGCATCGGGCACCGTCGATTCCCGACCTGTTGATCGCAGCCACAGCGGA
AATGTCCGGGCTGACGGTCCTCAGCGTTGACAAGGATTTCAGCCTGATCGCTGACATCACGGGGCAACCGATCGAGACGC
TTCGAATGGCGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8497.50 Da
• Isoelectric Point: 6.4669

>AT36292 WP_083145609.1 NZ_AP022598:494960-495187 [Mycolicibacterium parafortuitum]
MADILIRDLSDAAVAHIDATAAAQGLSRQEYLRRRFEAERPHGEPRRGLTIDDLRRAARAASDLDNPEVMDRAWR

Nucleotide

• Length: 228 bp

>AT36292 NZ_AP022598:494960-495187 [Mycolicibacterium parafortuitum]
ATGGCAGACATATTGATCAGAGATTTGTCGGACGCCGCCGTGGCTCATATCGACGCCACCGCCGCGGCACAGGGCCTGTC
GCGGCAGGAGTACCTCAGGCGACGCTTCGAGGCCGAACGCCCTCACGGCGAACCTCGCCGTGGGTTGACGATCGACGATC
TCCGCCGCGCGGCGCGCGCGGCCTCCGACCTCGATAACCCCGAGGTGATGGACCGAGCGTGGCGGTGA