Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4331825..4332817 Replicon chromosome
Accession NZ_AP022597
Organism Mycobacterium paraintracellulare strain JCM 30622

Toxin (Protein)


Gene name pezT Uniprot ID A0A7I7TTS6
Locus tag G6N00_RS20850 Protein ID WP_014384645.1
Coordinates 4332239..4332817 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A7I7TS83
Locus tag G6N00_RS20845 Protein ID WP_009956380.1
Coordinates 4331825..4332214 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N00_RS20820 4327276..4329279 + 2004 WP_014384640.1 phosphotransferase -
G6N00_RS20825 4329276..4329776 + 501 WP_014384641.1 gluconokinase -
G6N00_RS20830 4329847..4330458 - 612 WP_014384642.1 TetR/AcrR family transcriptional regulator -
G6N00_RS20835 4330628..4331452 + 825 WP_080588061.1 SAM-dependent methyltransferase -
G6N00_RS20840 4331492..4331767 + 276 WP_014384644.1 hypothetical protein -
G6N00_RS20845 4331825..4332214 + 390 WP_009956380.1 hypothetical protein Antitoxin
G6N00_RS20850 4332239..4332817 + 579 WP_014384645.1 zeta toxin family protein Toxin
G6N00_RS20855 4332837..4333904 - 1068 WP_014384646.1 DoxX family membrane protein -
G6N00_RS20860 4334000..4334560 + 561 WP_158020468.1 pyrazinamidase PncA -
G6N00_RS20865 4334560..4335360 + 801 WP_009956375.1 nuclear transport factor 2 family protein -
G6N00_RS20870 4335372..4335722 - 351 WP_009956374.1 DoxX family protein -
G6N00_RS20875 4335888..4336859 + 972 WP_014384649.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21104.34 Da        Isoelectric Point: 11.2406

>T36291 WP_014384645.1 NZ_AP022597:4332239-4332817 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLRRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD

Download         Length: 579 bp

>T36291 NZ_AP022597:4332239-4332817 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGCGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13512.89 Da        Isoelectric Point: 5.1828

>AT36291 WP_009956380.1 NZ_AP022597:4331825-4332214 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT36291 NZ_AP022597:4331825-4332214 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAAGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I7TTS6

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7TS83

References