36290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3004358..3004922 Replicon chromosome
Accession NZ_AP022597
Organism Mycobacterium paraintracellulare strain JCM 30622

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N00_RS14980 Protein ID WP_041784823.1
Coordinates 3004551..3004922 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N00_RS14975 Protein ID WP_026071432.1
Coordinates 3004358..3004564 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N00_RS14955 2999973..3000971 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
G6N00_RS14960 3001017..3002162 - 1146 WP_179960060.1 hypothetical protein -
G6N00_RS14965 3002304..3003377 + 1074 WP_009953440.1 redox-regulated ATPase YchF -
G6N00_RS14970 3003457..3004119 - 663 WP_014384000.1 methyltransferase domain-containing protein -
G6N00_RS14975 3004358..3004564 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N00_RS14980 3004551..3004922 + 372 WP_041784823.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N00_RS14985 3004980..3005531 + 552 WP_038535279.1 VOC family protein -
G6N00_RS14990 3005610..3006008 + 399 WP_009953435.1 VOC family protein -
G6N00_RS14995 3006155..3006490 + 336 WP_014379387.1 hypothetical protein -
G6N00_RS26250 3006576..3006935 + 360 WP_179960061.1 hypothetical protein -
G6N00_RS15005 3007117..3007692 + 576 WP_139826564.1 C40 family peptidase -
G6N00_RS15010 3008055..3008378 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
G6N00_RS15015 3008427..3009110 - 684 WP_014384004.1 hypothetical protein -
G6N00_RS15020 3009257..3009466 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13877.21 Da        Isoelectric Point: 6.9118

>T36290 WP_041784823.1 NZ_AP022597:3004551-3004922 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Download         Length: 372 bp

>T36290 NZ_AP022597:3004551-3004922 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT36290 WP_026071432.1 NZ_AP022597:3004358-3004564 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT36290 NZ_AP022597:3004358-3004564 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References