Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3297548..3298204 Replicon chromosome
Accession NZ_AP022596
Organism Mycolicibacterium helvum strain JCM 30396

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N38_RS15530 Protein ID WP_163748909.1
Coordinates 3297758..3298204 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N38_RS15525 Protein ID WP_163748906.1
Coordinates 3297548..3297754 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N38_RS15515 3293562..3295148 + 1587 WP_163748902.1 serine hydrolase -
G6N38_RS15520 3295145..3297544 + 2400 WP_163748904.1 HAD-IC family P-type ATPase -
G6N38_RS15525 3297548..3297754 + 207 WP_163748906.1 antitoxin Antitoxin
G6N38_RS15530 3297758..3298204 + 447 WP_163748909.1 SRPBCC family protein Toxin
G6N38_RS15535 3298219..3298602 - 384 WP_163748910.1 hypothetical protein -
G6N38_RS15540 3298744..3298971 + 228 WP_163748913.1 hypothetical protein -
G6N38_RS15545 3298968..3300533 - 1566 WP_163748915.1 GAF domain-containing protein -
G6N38_RS15550 3300526..3301167 - 642 WP_163748917.1 response regulator transcription factor -
G6N38_RS15555 3301395..3302282 + 888 WP_163748919.1 amidohydrolase family protein -
G6N38_RS15560 3302279..3303166 - 888 WP_163748921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15911.56 Da        Isoelectric Point: 10.2881

>T36287 WP_163748909.1 NZ_AP022596:3297758-3298204 [Mycolicibacterium helvum]
MAKLSVSVDVPLPPEQAWQHASDLSRYKDWLTIHRVWRSTLPDTLDKGTVVESIVEVKGMPNRVKWTIVHFKAPEAMTLN
GVGVGGVKVKLIGKVRASASDANASVVTMDVHLGGPALFGPIGMIVAGALRGDIKESLNRFVTVFAPS

Download         Length: 447 bp

>T36287 NZ_AP022596:3297758-3298204 [Mycolicibacterium helvum]
ATGGCGAAACTCTCAGTATCTGTCGACGTTCCACTCCCACCCGAGCAAGCCTGGCAGCACGCCTCGGACCTGTCGCGCTA
TAAGGATTGGCTGACCATCCACCGGGTCTGGCGCTCCACACTGCCCGACACTCTGGACAAGGGCACGGTTGTGGAGTCCA
TCGTCGAGGTCAAGGGCATGCCCAACCGGGTGAAGTGGACGATCGTCCATTTCAAGGCGCCGGAGGCGATGACACTCAAT
GGTGTCGGCGTCGGCGGGGTCAAGGTCAAGCTGATCGGCAAGGTCCGGGCGAGCGCCTCGGACGCGAACGCCTCGGTGGT
GACTATGGACGTCCATCTGGGTGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTGGCCGGGGCGCTGCGTGGCGACA
TCAAGGAGTCGCTGAACCGGTTCGTGACGGTCTTCGCTCCGTCCTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7439.29 Da        Isoelectric Point: 4.6050

>AT36287 WP_163748906.1 NZ_AP022596:3297548-3297754 [Mycolicibacterium helvum]
MGFLDKALDKTKEVLSENADKVGQAIDKAGDIIDEKTQGKYASTVDKVQDAAKNIVEKNRTEKGDEQV

Download         Length: 207 bp

>AT36287 NZ_AP022596:3297548-3297754 [Mycolicibacterium helvum]
ATGGGATTCCTCGATAAAGCCCTCGACAAGACCAAAGAAGTCCTGAGCGAGAATGCCGACAAGGTGGGGCAGGCCATCGA
CAAGGCCGGTGACATCATCGACGAGAAGACACAGGGCAAGTACGCCAGCACCGTGGACAAGGTGCAGGACGCCGCGAAGA
ACATCGTCGAGAAGAACCGCACCGAAAAGGGCGACGAACAAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References