Detailed information of TA system TA036286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 395564..396123
• Replicon: chromosome
• Accession: NZ_AP022596
• Organism: Mycolicibacterium helvum strain JCM 30396

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6N38_RS01820
• Protein ID: WP_163745985.1
• Coordinates: 395845..396123 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G6N38_RS01815
• Protein ID: WP_179968532.1
• Coordinates: 395564..395848 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N38_RS01795	392566..393210	+	645	WP_163745980.1	cysteine hydrolase	-
G6N38_RS01800	393207..393764	+	558	WP_163745981.1	hypothetical protein	-
G6N38_RS01805	393778..394392	+	615	WP_163745982.1	glyoxalase	-
G6N38_RS01810	394400..395230	+	831	WP_163745983.1	enoyl-CoA hydratase/isomerase family protein	-
G6N38_RS01815	395564..395848	+	285	WP_179968532.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N38_RS01820	395845..396123	+	279	WP_163745985.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N38_RS01825	396539..397483	+	945	WP_163745986.1	hypothetical protein	-
G6N38_RS01830	397768..398403	+	636	WP_163745987.1	DUF3887 domain-containing protein	-
G6N38_RS01835	398506..399489	-	984	WP_163751741.1	AraC family transcriptional regulator	-
G6N38_RS01840	399720..400538	+	819	WP_163745988.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (38-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-74)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10712.24 Da
• Isoelectric Point: 11.4857

>T36286 WP_163745985.1 NZ_AP022596:395845-396123 [Mycolicibacterium helvum]
VTDRRYELVVAPTVRRQLAETLPEAVTFAAYKFITGPLLDNPHRVGERLRPPLEDRRSARRGTYRVIYRIDDAHRRVTVV
GVFSRADSHRKQ

Nucleotide

• Length: 279 bp

>T36286 NZ_AP022596:395845-396123 [Mycolicibacterium helvum]
GTGACCGACCGGCGCTACGAGCTGGTCGTTGCCCCGACTGTGCGACGGCAGTTGGCCGAGACCCTGCCGGAGGCGGTGAC
GTTCGCGGCCTACAAGTTCATCACCGGACCATTGCTGGACAACCCGCATCGGGTCGGTGAGCGATTGAGGCCGCCCCTGG
AAGATCGTCGCAGTGCCCGCCGGGGCACGTACCGCGTGATCTACCGCATTGACGACGCGCACCGACGCGTCACGGTCGTG
GGTGTGTTCAGCCGCGCCGACTCCCACCGCAAGCAGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9846.04 Da
• Isoelectric Point: 4.4380

>AT36286 WP_179968532.1 NZ_AP022596:395564-395848 [Mycolicibacterium helvum]
MPEISSLAETKAHLSELVARVGEQHERVTVTVHGRPAAVLIAVDDLESLEETIAVLSDSAALRALSEADAELARGESVSE
GDLAAAMQARRAGK

Nucleotide

• Length: 285 bp

>AT36286 NZ_AP022596:395564-395848 [Mycolicibacterium helvum]
ATGCCGGAGATCAGTTCACTGGCTGAGACGAAAGCCCACCTGTCGGAGTTGGTGGCGCGGGTCGGAGAGCAGCACGAACG
CGTGACGGTCACCGTCCATGGGCGGCCGGCCGCGGTCTTGATCGCCGTCGACGATCTGGAGTCACTCGAGGAGACCATCG
CAGTCCTGTCCGATTCTGCGGCGCTGCGCGCACTAAGCGAGGCCGATGCCGAACTGGCCCGAGGAGAGAGCGTGAGTGAG
GGCGATCTCGCCGCGGCGATGCAGGCTCGTCGAGCTGGGAAGTGA