Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4025178..4025739 Replicon chromosome
Accession NZ_AP022595
Organism Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G6N13_RS20140 Protein ID WP_163699795.1
Coordinates 4025461..4025739 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G6N13_RS20135 Protein ID WP_163699793.1
Coordinates 4025178..4025459 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N13_RS20110 4021594..4021905 + 312 WP_163699785.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
G6N13_RS20115 4021902..4022213 + 312 WP_163699786.1 hypothetical protein -
G6N13_RS20120 4022738..4023454 + 717 WP_163699787.1 helix-turn-helix domain-containing protein -
G6N13_RS20125 4023503..4023907 + 405 WP_163699789.1 HAD hydrolase-like protein -
G6N13_RS20130 4024074..4024598 + 525 WP_163699791.1 bleomycin resistance family protein -
G6N13_RS20135 4025178..4025459 + 282 WP_163699793.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N13_RS20140 4025461..4025739 + 279 WP_163699795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N13_RS20150 4026216..4026401 + 186 WP_163699798.1 long chain fatty acid-CoA synthetase Faa4p -
G6N13_RS20155 4026441..4026689 - 249 WP_163702353.1 OB-fold domain-containing protein -
G6N13_RS20160 4026780..4027625 - 846 WP_163699800.1 sulfurtransferase -
G6N13_RS20165 4027952..4029103 + 1152 WP_163699802.1 P1 family peptidase -
G6N13_RS20170 4029105..4029917 - 813 WP_163699804.1 thioesterase family protein -
G6N13_RS20175 4029976..4030164 + 189 Protein_3974 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10499.02 Da        Isoelectric Point: 10.7171

>T36285 WP_163699795.1 NZ_AP022595:4025461-4025739 [Mycolicibacterium sarraceniae]
MESDADYATRFTASARRDLDKLPPRILAAVIEFAFGDLARAPRLVGKPLRGDLVGQHSARRGPYRLLLRIDDTTKTVWVH
RVDHRSDIYRTP

Download         Length: 279 bp

>T36285 NZ_AP022595:4025461-4025739 [Mycolicibacterium sarraceniae]
ATGGAATCCGACGCTGACTACGCGACGCGGTTCACAGCCTCGGCTCGGCGCGATCTGGACAAACTCCCGCCGCGGATTCT
CGCAGCCGTGATCGAGTTCGCGTTTGGAGATCTGGCACGAGCTCCCCGTCTGGTTGGGAAGCCGCTGCGCGGCGACCTCG
TCGGTCAGCACAGTGCCCGGCGAGGCCCCTACCGCCTCCTCCTCCGCATCGACGACACGACCAAAACCGTCTGGGTGCAC
CGCGTCGACCACCGCTCAGACATCTACCGGACGCCCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10314.57 Da        Isoelectric Point: 4.6536

>AT36285 WP_163699793.1 NZ_AP022595:4025178-4025459 [Mycolicibacterium sarraceniae]
MRILPISQVKSKINEYVDAVAETRDQITITKNGSPAAVLIGVDEWESIKETLYWLSQPGITESVAESEADVAAGRTFGED
EIRAAYHAPRRPR

Download         Length: 282 bp

>AT36285 NZ_AP022595:4025178-4025459 [Mycolicibacterium sarraceniae]
ATGCGGATACTGCCGATTTCTCAGGTGAAAAGCAAGATCAACGAGTACGTCGATGCTGTCGCCGAGACGCGTGACCAGAT
CACCATCACCAAGAACGGTTCGCCAGCGGCCGTACTCATCGGTGTTGATGAGTGGGAGTCGATCAAGGAAACGCTGTACT
GGCTCTCTCAGCCCGGAATCACCGAGTCGGTGGCCGAATCAGAGGCCGACGTCGCCGCGGGGCGCACGTTCGGTGAAGAC
GAGATTCGCGCGGCGTACCACGCGCCTCGGCGACCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References