Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3017113..3017675 Replicon chromosome
Accession NZ_AP022595
Organism Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N13_RS14930 Protein ID WP_163698186.1
Coordinates 3017113..3017442 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N13_RS14935 Protein ID WP_163698188.1
Coordinates 3017439..3017675 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N13_RS14915 3013250..3014242 + 993 WP_163698180.1 extracellular solute-binding protein -
G6N13_RS14920 3014239..3015828 + 1590 WP_163698182.1 iron ABC transporter permease -
G6N13_RS14925 3015825..3016850 + 1026 WP_163698184.1 ABC transporter ATP-binding protein -
G6N13_RS14930 3017113..3017442 - 330 WP_163698186.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N13_RS14935 3017439..3017675 - 237 WP_163698188.1 DUF2191 domain-containing protein Antitoxin
G6N13_RS14940 3017868..3018152 + 285 WP_163698190.1 DUF1330 domain-containing protein -
G6N13_RS14945 3018154..3018810 - 657 WP_163698192.1 3-oxoacid CoA-transferase subunit B -
G6N13_RS14950 3018810..3019574 - 765 WP_163698194.1 CoA transferase subunit A -
G6N13_RS14955 3019746..3020519 + 774 WP_163698196.1 IclR family transcriptional regulator -
G6N13_RS14960 3020617..3022194 + 1578 WP_163698198.1 methylmalonyl-CoA mutase -
G6N13_RS14965 3022194..3022595 + 402 WP_163698200.1 cobalamin B12-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11579.51 Da        Isoelectric Point: 7.6430

>T36283 WP_163698186.1 NZ_AP022595:c3017442-3017113 [Mycolicibacterium sarraceniae]
VSGLPAHGELWWCEMAEIGRRPVVVLSRDAAIPRLRRAIVAPCTTTIRGLASEVVLEPGSDPVPRRSAVNLDSVESVSVA
VLVDRLGRLADARMRAICAALQVAVDCPG

Download         Length: 330 bp

>T36283 NZ_AP022595:c3017442-3017113 [Mycolicibacterium sarraceniae]
GTGAGCGGACTTCCGGCACACGGAGAGCTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGTCCAGTCGTTGTTCTCTC
GCGCGATGCGGCGATCCCCCGGCTTCGACGCGCGATCGTCGCGCCCTGCACCACAACCATTCGGGGGCTGGCCAGCGAGG
TTGTTCTTGAACCCGGTTCCGACCCGGTCCCGCGTCGTTCCGCGGTGAATCTGGACTCTGTCGAAAGTGTCTCGGTCGCG
GTGTTGGTCGATCGGCTTGGCCGCCTCGCCGACGCCCGGATGCGCGCCATCTGTGCGGCTCTGCAGGTTGCGGTCGACTG
CCCTGGATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8423.26 Da        Isoelectric Point: 4.5417

>AT36283 WP_163698188.1 NZ_AP022595:c3017675-3017439 [Mycolicibacterium sarraceniae]
MNRIRLSTTVDAGLLSSARDVRAGITDAALIDEALGALLARHRSAEVDASYAAYDRHPVDEPDEWGDLASWRRAAADS

Download         Length: 237 bp

>AT36283 NZ_AP022595:c3017675-3017439 [Mycolicibacterium sarraceniae]
ATGAATCGCATACGCCTGAGCACTACTGTCGATGCCGGACTGTTGAGCAGTGCACGCGACGTGCGGGCAGGAATCACTGA
TGCAGCTCTTATCGATGAGGCGCTCGGGGCATTACTTGCTCGCCATCGATCGGCCGAGGTGGATGCGAGCTATGCGGCCT
ACGACAGGCACCCGGTTGATGAGCCCGACGAGTGGGGCGACCTAGCGTCGTGGCGGCGGGCGGCTGCAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References