Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2626674..2627218 Replicon chromosome
Accession NZ_AP022595
Organism Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G6N13_RS13220 Protein ID WP_163697642.1
Coordinates 2626991..2627218 (+) Length 76 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G6N13_RS13215 Protein ID WP_163697640.1
Coordinates 2626674..2626958 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N13_RS13195 2622592..2623146 - 555 WP_163697631.1 lipid droplet-associated protein -
G6N13_RS13200 2623201..2624202 + 1002 WP_163697634.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
G6N13_RS13205 2624211..2625344 - 1134 WP_163697636.1 hypothetical protein -
G6N13_RS13210 2625438..2626517 + 1080 WP_163697638.1 redox-regulated ATPase YchF -
G6N13_RS13215 2626674..2626958 + 285 WP_163697640.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N13_RS13220 2626991..2627218 + 228 WP_163697642.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N13_RS13230 2627540..2627950 - 411 WP_163697644.1 PPOX class F420-dependent oxidoreductase -
G6N13_RS13235 2628223..2628747 + 525 WP_163697646.1 DUF1942 domain-containing protein -
G6N13_RS13240 2628960..2629640 - 681 WP_179965151.1 guanylate cyclase -
G6N13_RS24125 2629678..2629836 + 159 WP_170310448.1 hypothetical protein -
G6N13_RS13245 2629833..2630621 - 789 WP_163697649.1 adenylate/guanylate cyclase domain-containing protein -
G6N13_RS13250 2630657..2630923 + 267 WP_163697651.1 cytochrome P450 -
G6N13_RS13255 2630968..2631261 + 294 WP_163697653.1 helix-turn-helix transcriptional regulator -
G6N13_RS13260 2631258..2632115 - 858 WP_163697655.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(23-73)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8853.24 Da        Isoelectric Point: 10.3892

>T36282 WP_163697642.1 NZ_AP022595:2626991-2627218 [Mycolicibacterium sarraceniae]
MALTDDLPQAIAVACWEFIRGPLAENPHRVGKPLRNQLQGRYSARRGEFRVVYQIFDERVVVRVIHIAYRRDVYR

Download         Length: 228 bp

>T36282 NZ_AP022595:2626991-2627218 [Mycolicibacterium sarraceniae]
ATGGCGCTCACCGATGACCTACCCCAGGCAATCGCTGTCGCGTGTTGGGAGTTCATTCGCGGGCCACTCGCAGAGAATCC
TCATCGCGTCGGCAAGCCGCTACGCAACCAGCTGCAGGGGCGGTACTCGGCACGACGAGGCGAATTCCGAGTGGTATACC
AGATTTTCGACGAACGAGTGGTTGTCCGAGTGATCCACATCGCGTATCGCCGTGACGTTTATCGGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10471.77 Da        Isoelectric Point: 4.2158

>AT36282 WP_163697640.1 NZ_AP022595:2626674-2626958 [Mycolicibacterium sarraceniae]
MSTLPLAEVRANLSKIVDEAVRTHQRIEVTRQGRRAAVILSADDYDSIMETLEILSDRDLLLEIREAEAEADAGETYTLD
EVTEAMRTVGRLPG

Download         Length: 285 bp

>AT36282 NZ_AP022595:2626674-2626958 [Mycolicibacterium sarraceniae]
ATGTCGACCCTCCCGCTTGCCGAAGTCCGCGCAAACCTATCGAAGATTGTCGACGAAGCGGTCCGTACTCACCAGCGCAT
CGAGGTCACCCGTCAAGGGCGTCGGGCGGCGGTGATTCTCAGTGCAGACGATTACGACTCGATCATGGAAACTCTGGAGA
TTCTGAGTGATCGCGATCTGCTGCTCGAAATCCGAGAAGCCGAAGCCGAGGCTGACGCGGGCGAGACCTACACGCTCGAT
GAGGTGACCGAAGCTATGCGTACCGTCGGGCGGTTGCCAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References