Detailed information of TA system TA036281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2341138..2341796
• Replicon: chromosome
• Accession: NZ_AP022595
• Organism: Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N13_RS11745
• Protein ID: WP_163697215.1
• Coordinates: 2341398..2341796 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N13_RS11740
• Protein ID: WP_163697213.1
• Coordinates: 2341138..2341401 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N13_RS11715	2336377..2337816	+	1440	WP_163697205.1	hypothetical protein	-
G6N13_RS11720	2338356..2338727	+	372	WP_163697207.1	hypothetical protein	-
G6N13_RS11725	2339133..2340053	+	921	WP_163697209.1	hypothetical protein	-
G6N13_RS11730	2340076..2340384	-	309	Protein_2308	transposase	-
G6N13_RS11735	2340624..2341094	+	471	WP_163697211.1	hypothetical protein	-
G6N13_RS11740	2341138..2341401	+	264	WP_163697213.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
G6N13_RS11745	2341398..2341796	+	399	WP_163697215.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N13_RS11750	2341804..2342286	-	483	WP_170310489.1	hypothetical protein	-
G6N13_RS11755	2342402..2343205	+	804	WP_163702023.1	glycoside hydrolase family 16 protein	-
G6N13_RS11760	2343275..2344099	-	825	WP_163702025.1	DUF559 domain-containing protein	-
G6N13_RS11765	2344265..2345464	-	1200	WP_163702028.1	TetR/AcrR family transcriptional regulator	-
G6N13_RS11770	2345500..2346312	-	813	WP_163697217.1	mannan-binding family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2340076..2340432	356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (1-86)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13752.54 Da
• Isoelectric Point: 4.5127

>T36281 WP_163697215.1 NZ_AP022595:2341398-2341796 [Mycolicibacterium sarraceniae]
MIVDTSAIVAIALNESGRDRLVDALLGAPAPKISAATLVEVGAVLTRRLAPEDLRRVERLIGQLGIATVPFDAEQAASAT
RAYREFGRGSGHPASLNLGDCYSYALAAVTGEPLLYVGDDFAHTDIASAATD

Nucleotide

• Length: 399 bp

>T36281 NZ_AP022595:2341398-2341796 [Mycolicibacterium sarraceniae]
ATGATCGTCGATACTTCGGCGATCGTGGCGATCGCGCTCAATGAGTCTGGTCGCGATCGATTGGTCGACGCACTACTGGG
CGCACCCGCGCCCAAGATTTCCGCGGCCACGCTCGTCGAGGTCGGGGCCGTGCTGACGAGGCGACTGGCGCCCGAAGATC
TGAGGCGTGTCGAGCGCCTCATCGGCCAGCTGGGCATCGCAACAGTGCCTTTCGACGCCGAGCAGGCCGCAAGTGCTACC
CGCGCCTACCGCGAGTTTGGTCGTGGCAGCGGCCATCCCGCCAGCCTGAACCTCGGCGACTGCTACTCCTACGCCCTTGC
CGCGGTCACTGGCGAACCATTGCTGTACGTCGGCGACGACTTCGCGCATACCGACATCGCTTCTGCCGCAACCGATTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9740.01 Da
• Isoelectric Point: 9.9858

>AT36281 WP_163697213.1 NZ_AP022595:2341138-2341401 [Mycolicibacterium sarraceniae]
MSLNIKNERTVALVRELARRTGLSQTSAVEEAVRAKLAELTGAESPNTRRGKVNELLSELDRSMTARQRKRIRAEETELY
DESGLPA

Nucleotide

• Length: 264 bp

>AT36281 NZ_AP022595:2341138-2341401 [Mycolicibacterium sarraceniae]
ATGAGTCTGAACATCAAGAACGAGCGGACTGTCGCGTTGGTGCGGGAACTTGCGCGCCGTACCGGGCTCAGCCAGACGAG
TGCTGTCGAAGAGGCGGTGCGCGCCAAGCTCGCGGAACTTACCGGTGCGGAGAGCCCGAACACTCGCCGCGGCAAGGTGA
ATGAGTTGCTCTCCGAATTGGATCGGTCGATGACTGCGCGGCAGCGCAAGCGGATCCGCGCAGAGGAAACCGAGTTGTAC
GACGAGAGCGGGTTGCCTGCATGA