Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2341138..2341796 Replicon chromosome
Accession NZ_AP022595
Organism Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N13_RS11745 Protein ID WP_163697215.1
Coordinates 2341398..2341796 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N13_RS11740 Protein ID WP_163697213.1
Coordinates 2341138..2341401 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N13_RS11715 2336377..2337816 + 1440 WP_163697205.1 hypothetical protein -
G6N13_RS11720 2338356..2338727 + 372 WP_163697207.1 hypothetical protein -
G6N13_RS11725 2339133..2340053 + 921 WP_163697209.1 hypothetical protein -
G6N13_RS11730 2340076..2340384 - 309 Protein_2308 transposase -
G6N13_RS11735 2340624..2341094 + 471 WP_163697211.1 hypothetical protein -
G6N13_RS11740 2341138..2341401 + 264 WP_163697213.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N13_RS11745 2341398..2341796 + 399 WP_163697215.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N13_RS11750 2341804..2342286 - 483 WP_170310489.1 hypothetical protein -
G6N13_RS11755 2342402..2343205 + 804 WP_163702023.1 glycoside hydrolase family 16 protein -
G6N13_RS11760 2343275..2344099 - 825 WP_163702025.1 DUF559 domain-containing protein -
G6N13_RS11765 2344265..2345464 - 1200 WP_163702028.1 TetR/AcrR family transcriptional regulator -
G6N13_RS11770 2345500..2346312 - 813 WP_163697217.1 mannan-binding family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2340076..2340432 356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13752.54 Da        Isoelectric Point: 4.5127

>T36281 WP_163697215.1 NZ_AP022595:2341398-2341796 [Mycolicibacterium sarraceniae]
MIVDTSAIVAIALNESGRDRLVDALLGAPAPKISAATLVEVGAVLTRRLAPEDLRRVERLIGQLGIATVPFDAEQAASAT
RAYREFGRGSGHPASLNLGDCYSYALAAVTGEPLLYVGDDFAHTDIASAATD

Download         Length: 399 bp

>T36281 NZ_AP022595:2341398-2341796 [Mycolicibacterium sarraceniae]
ATGATCGTCGATACTTCGGCGATCGTGGCGATCGCGCTCAATGAGTCTGGTCGCGATCGATTGGTCGACGCACTACTGGG
CGCACCCGCGCCCAAGATTTCCGCGGCCACGCTCGTCGAGGTCGGGGCCGTGCTGACGAGGCGACTGGCGCCCGAAGATC
TGAGGCGTGTCGAGCGCCTCATCGGCCAGCTGGGCATCGCAACAGTGCCTTTCGACGCCGAGCAGGCCGCAAGTGCTACC
CGCGCCTACCGCGAGTTTGGTCGTGGCAGCGGCCATCCCGCCAGCCTGAACCTCGGCGACTGCTACTCCTACGCCCTTGC
CGCGGTCACTGGCGAACCATTGCTGTACGTCGGCGACGACTTCGCGCATACCGACATCGCTTCTGCCGCAACCGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9740.01 Da        Isoelectric Point: 9.9858

>AT36281 WP_163697213.1 NZ_AP022595:2341138-2341401 [Mycolicibacterium sarraceniae]
MSLNIKNERTVALVRELARRTGLSQTSAVEEAVRAKLAELTGAESPNTRRGKVNELLSELDRSMTARQRKRIRAEETELY
DESGLPA

Download         Length: 264 bp

>AT36281 NZ_AP022595:2341138-2341401 [Mycolicibacterium sarraceniae]
ATGAGTCTGAACATCAAGAACGAGCGGACTGTCGCGTTGGTGCGGGAACTTGCGCGCCGTACCGGGCTCAGCCAGACGAG
TGCTGTCGAAGAGGCGGTGCGCGCCAAGCTCGCGGAACTTACCGGTGCGGAGAGCCCGAACACTCGCCGCGGCAAGGTGA
ATGAGTTGCTCTCCGAATTGGATCGGTCGATGACTGCGCGGCAGCGCAAGCGGATCCGCGCAGAGGAAACCGAGTTGTAC
GACGAGAGCGGGTTGCCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References