Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 783409..784064 Replicon chromosome
Accession NZ_AP022595
Organism Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N13_RS04070 Protein ID WP_163694912.1
Coordinates 783409..783855 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N13_RS04075 Protein ID WP_163694913.1
Coordinates 783858..784064 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N13_RS04045 779192..780079 + 888 WP_163694908.1 hypothetical protein -
G6N13_RS04050 780435..781076 + 642 WP_163701665.1 response regulator transcription factor -
G6N13_RS04055 781069..782640 + 1572 WP_163694909.1 GAF domain-containing sensor histidine kinase -
G6N13_RS04060 782660..782887 - 228 WP_163694910.1 hypothetical protein -
G6N13_RS04065 783029..783412 + 384 WP_163694911.1 hypothetical protein -
G6N13_RS04070 783409..783855 - 447 WP_163694912.1 SRPBCC family protein Toxin
G6N13_RS04075 783858..784064 - 207 WP_163694913.1 antitoxin Antitoxin
G6N13_RS04080 784068..786470 - 2403 WP_163694914.1 HAD-IC family P-type ATPase -
G6N13_RS04085 786467..788053 - 1587 WP_163694915.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16013.58 Da        Isoelectric Point: 8.5134

>T36280 WP_163694912.1 NZ_AP022595:c783855-783409 [Mycolicibacterium sarraceniae]
MAKLSVSVDVPLSPEYAWQYASDLSRYQDWLTIHRVWRSTLPETLEKGTVVESIVEVKGMPNRVKWTIVHFNAPETMTLN
GVGVGGVKVKLIGKVRASAVDPDTSVVTMDVHLGGAPLFGPIGVVVAAALRGDIKESLNRFVTVFAPG

Download         Length: 447 bp

>T36280 NZ_AP022595:c783855-783409 [Mycolicibacterium sarraceniae]
ATGGCGAAACTCTCAGTATCGGTAGACGTTCCACTCTCGCCCGAATATGCCTGGCAGTACGCCTCGGACCTGTCGCGCTA
CCAGGATTGGCTGACCATCCACCGGGTTTGGCGCTCCACACTGCCCGAGACCCTCGAGAAGGGCACCGTCGTGGAGTCCA
TCGTCGAAGTCAAGGGCATGCCCAACCGGGTGAAGTGGACAATCGTGCACTTCAACGCGCCGGAGACGATGACGCTCAAC
GGCGTCGGCGTCGGCGGGGTCAAGGTCAAGCTCATTGGCAAGGTCCGGGCGAGCGCCGTGGACCCGGACACCTCGGTGGT
GACCATGGATGTCCATCTGGGTGGTGCGCCGCTGTTCGGACCGATCGGCGTGGTCGTGGCCGCTGCGCTGCGGGGCGACA
TCAAGGAGTCGCTGAACCGGTTTGTGACCGTCTTCGCGCCGGGCTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7425.26 Da        Isoelectric Point: 4.7730

>AT36280 WP_163694913.1 NZ_AP022595:c784064-783858 [Mycolicibacterium sarraceniae]
MGFLEKALDKTKEVLSENADKVGQAIDKAGDIIDEKTQGKYSSTVDKVQDAAKNIVEKNRTDKGDPQT

Download         Length: 207 bp

>AT36280 NZ_AP022595:c784064-783858 [Mycolicibacterium sarraceniae]
ATGGGATTCCTCGAAAAAGCTCTCGACAAGACCAAAGAAGTCTTGAGCGAGAATGCCGACAAAGTGGGGCAGGCCATCGA
CAAGGCCGGCGACATCATCGACGAGAAGACGCAGGGCAAATACTCCAGCACAGTCGACAAGGTGCAGGATGCGGCCAAGA
ACATCGTCGAGAAGAACCGCACCGATAAGGGTGACCCACAAACCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References