Detailed information of TA system TA036280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 783409..784064
• Replicon: chromosome
• Accession: NZ_AP022595
• Organism: Mycolicibacterium sarraceniae strain JCM 30395

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: G6N13_RS04070
• Protein ID: WP_163694912.1
• Coordinates: 783409..783855 (-)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: -
• Locus tag: G6N13_RS04075
• Protein ID: WP_163694913.1
• Coordinates: 783858..784064 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N13_RS04045	779192..780079	+	888	WP_163694908.1	hypothetical protein	-
G6N13_RS04050	780435..781076	+	642	WP_163701665.1	response regulator transcription factor	-
G6N13_RS04055	781069..782640	+	1572	WP_163694909.1	GAF domain-containing sensor histidine kinase	-
G6N13_RS04060	782660..782887	-	228	WP_163694910.1	hypothetical protein	-
G6N13_RS04065	783029..783412	+	384	WP_163694911.1	hypothetical protein	-
G6N13_RS04070	783409..783855	-	447	WP_163694912.1	SRPBCC family protein	Toxin
G6N13_RS04075	783858..784064	-	207	WP_163694913.1	antitoxin	Antitoxin
G6N13_RS04080	784068..786470	-	2403	WP_163694914.1	HAD-IC family P-type ATPase	-
G6N13_RS04085	786467..788053	-	1587	WP_163694915.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-145)

Antitoxin

• Antitoxin Rv0909/MT0933 (8-54)

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 16013.58 Da
• Isoelectric Point: 8.5134

>T36280 WP_163694912.1 NZ_AP022595:c783855-783409 [Mycolicibacterium sarraceniae]
MAKLSVSVDVPLSPEYAWQYASDLSRYQDWLTIHRVWRSTLPETLEKGTVVESIVEVKGMPNRVKWTIVHFNAPETMTLN
GVGVGGVKVKLIGKVRASAVDPDTSVVTMDVHLGGAPLFGPIGVVVAAALRGDIKESLNRFVTVFAPG

Nucleotide

• Length: 447 bp

>T36280 NZ_AP022595:c783855-783409 [Mycolicibacterium sarraceniae]
ATGGCGAAACTCTCAGTATCGGTAGACGTTCCACTCTCGCCCGAATATGCCTGGCAGTACGCCTCGGACCTGTCGCGCTA
CCAGGATTGGCTGACCATCCACCGGGTTTGGCGCTCCACACTGCCCGAGACCCTCGAGAAGGGCACCGTCGTGGAGTCCA
TCGTCGAAGTCAAGGGCATGCCCAACCGGGTGAAGTGGACAATCGTGCACTTCAACGCGCCGGAGACGATGACGCTCAAC
GGCGTCGGCGTCGGCGGGGTCAAGGTCAAGCTCATTGGCAAGGTCCGGGCGAGCGCCGTGGACCCGGACACCTCGGTGGT
GACCATGGATGTCCATCTGGGTGGTGCGCCGCTGTTCGGACCGATCGGCGTGGTCGTGGCCGCTGCGCTGCGGGGCGACA
TCAAGGAGTCGCTGAACCGGTTTGTGACCGTCTTCGCGCCGGGCTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7425.26 Da
• Isoelectric Point: 4.7730

>AT36280 WP_163694913.1 NZ_AP022595:c784064-783858 [Mycolicibacterium sarraceniae]
MGFLEKALDKTKEVLSENADKVGQAIDKAGDIIDEKTQGKYSSTVDKVQDAAKNIVEKNRTDKGDPQT

Nucleotide

• Length: 207 bp

>AT36280 NZ_AP022595:c784064-783858 [Mycolicibacterium sarraceniae]
ATGGGATTCCTCGAAAAAGCTCTCGACAAGACCAAAGAAGTCTTGAGCGAGAATGCCGACAAAGTGGGGCAGGCCATCGA
CAAGGCCGGCGACATCATCGACGAGAAGACGCAGGGCAAATACTCCAGCACAGTCGACAAGGTGCAGGATGCGGCCAAGA
ACATCGTCGAGAAGAACCGCACCGATAAGGGTGACCCACAAACCTAG