Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3875532..3876152 Replicon chromosome
Accession NZ_AP022594
Organism Mycolicibacillus koreensis strain JCM 19956

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N11_RS19195 Protein ID WP_085303121.1
Coordinates 3875715..3876152 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N11_RS19190 Protein ID WP_085303119.1
Coordinates 3875532..3875711 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N11_RS19180 3871427..3872995 + 1569 WP_085303115.1 serine hydrolase -
G6N11_RS19185 3872992..3875484 + 2493 WP_085303117.1 HAD-IC family P-type ATPase -
G6N11_RS19190 3875532..3875711 + 180 WP_085303119.1 antitoxin Antitoxin
G6N11_RS19195 3875715..3876152 + 438 WP_085303121.1 SRPBCC family protein Toxin
G6N11_RS19200 3876199..3876609 + 411 WP_085303122.1 hypothetical protein -
G6N11_RS19205 3876630..3879521 - 2892 WP_085303124.1 RND family transporter -
G6N11_RS19210 3879518..3879964 - 447 WP_197747571.1 hypothetical protein -
G6N11_RS19215 3879961..3880584 - 624 WP_085303126.1 TetR/AcrR family transcriptional regulator -
G6N11_RS19220 3880774..3881019 - 246 WP_085303128.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15803.51 Da        Isoelectric Point: 10.2418

>T36278 WP_085303121.1 NZ_AP022594:3875715-3876152 [Mycolicibacillus koreensis]
MAKLSGAIDVPLPPEEAWGHAADLTRYRDWLTIHRLWRSPLPDTLEKGTVVESIVEVKGMPNRIKWTIVHFKPPQAMTLN
GDGKGGVKIKLMAKVKPQGDASVVSFDVHLGGPALFGPIGMLVAGALRSDINESLKRFVTVFAPQ

Download         Length: 438 bp

>T36278 NZ_AP022594:3875715-3876152 [Mycolicibacillus koreensis]
ATGGCGAAGCTCTCCGGGGCCATCGATGTCCCGCTCCCGCCGGAGGAGGCCTGGGGGCACGCCGCGGACCTCACCCGCTA
TCGGGATTGGCTGACCATTCACCGGCTCTGGCGCTCGCCGCTGCCCGACACCCTGGAGAAGGGCACGGTCGTGGAATCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCACTTCAAGCCGCCGCAGGCGATGACCCTCAAC
GGCGACGGCAAAGGCGGGGTGAAGATCAAACTGATGGCCAAGGTCAAGCCCCAGGGCGACGCCTCGGTGGTCAGCTTCGA
CGTGCACCTGGGCGGCCCGGCGCTGTTCGGGCCGATCGGGATGCTGGTGGCCGGCGCGCTGCGCAGCGACATCAACGAGT
CGCTGAAACGGTTCGTGACGGTGTTCGCGCCGCAGTAG

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6372.08 Da        Isoelectric Point: 4.6944

>AT36278 WP_085303119.1 NZ_AP022594:3875532-3875711 [Mycolicibacillus koreensis]
MGFLDKAKDLLSKNADKVDQAIDKAGDFVDGKTEGKYADTVDKVQDAAKKAVNKTDPEN

Download         Length: 180 bp

>AT36278 NZ_AP022594:3875532-3875711 [Mycolicibacillus koreensis]
ATGGGTTTCCTGGACAAGGCGAAAGACCTGTTGTCGAAGAACGCCGACAAGGTCGATCAGGCGATCGACAAGGCCGGGGA
CTTCGTCGACGGCAAGACCGAGGGCAAATACGCCGACACCGTCGACAAGGTGCAGGACGCGGCCAAGAAGGCCGTGAACA
AAACCGACCCGGAGAACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References