Detailed information of TA system TA036276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 799211..799866
• Replicon: chromosome
• Accession: NZ_AP022594
• Organism: Mycolicibacillus koreensis strain JCM 19956

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N11_RS03650
• Protein ID: WP_174254727.1
• Coordinates: 799211..799609 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N11_RS03655
• Protein ID: WP_069390899.1
• Coordinates: 799606..799866 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N11_RS03645	798200..798655	+	456	WP_085302441.1	DUF1942 domain-containing protein	-
G6N11_RS03650	799211..799609	-	399	WP_174254727.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N11_RS03655	799606..799866	-	261	WP_069390899.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G6N11_RS03660	800011..800619	-	609	WP_085302439.1	hypothetical protein	-
G6N11_RS03665	800913..801344	-	432	WP_084228506.1	cellulose-binding domain-containing protein	-
G6N11_RS03670	801515..802129	+	615	WP_174254728.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
G6N11_RS03675	802152..802625	-	474	WP_069390901.1	SRPBCC family protein	-
G6N11_RS03680	802692..804209	-	1518	WP_085302461.1	AMP-binding protein	-
G6N11_RS03685	804296..804505	-	210	WP_131814635.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14113.12 Da
• Isoelectric Point: 4.3182

>T36276 WP_174254727.1 NZ_AP022594:c799609-799211 [Mycolicibacillus koreensis]
VTSIGLLDTSVFIAQESGRRLDASGVPDEVATTVITVAELNLGVLAAASADVRAQRLATLDAIADILVFPVDEDAARMWA
RLRMHLAETGQRVRINDLWIAAIAASRDLPVVTQDEDFHPLDGVAGLTVLRV

Nucleotide

• Length: 399 bp

>T36276 NZ_AP022594:c799609-799211 [Mycolicibacillus koreensis]
GTGACCTCCATTGGCCTGCTCGATACGTCCGTGTTCATCGCACAGGAGAGCGGTCGCCGACTCGACGCATCCGGAGTGCC
GGACGAGGTTGCGACGACCGTGATCACCGTGGCCGAACTCAACCTCGGCGTCCTTGCGGCTGCGTCGGCAGATGTGCGCG
CGCAACGACTGGCAACGCTCGACGCGATTGCCGACATACTTGTGTTTCCGGTCGACGAAGATGCAGCACGCATGTGGGCG
CGCCTTCGCATGCACTTGGCGGAGACCGGTCAGCGAGTACGAATCAACGACCTCTGGATCGCGGCAATTGCCGCTTCCCG
CGACCTACCAGTGGTCACGCAAGACGAGGATTTCCATCCCCTCGATGGAGTCGCCGGCCTGACTGTTCTGCGAGTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9380.61 Da
• Isoelectric Point: 6.3620

>AT36276 WP_069390899.1 NZ_AP022594:c799866-799606 [Mycolicibacillus koreensis]
MSEIASRELRNDTAGLLRRVQAGEEITVTVSGKAVARLTALQPARRRLLSREELLRRLERAQADPALRAELAELAGDTTD
DLGSPS

Nucleotide

• Length: 261 bp

>AT36276 NZ_AP022594:c799866-799606 [Mycolicibacillus koreensis]
ATGTCTGAAATTGCTTCCCGAGAGCTGCGCAACGACACCGCAGGGCTGCTGCGGCGCGTCCAGGCGGGGGAGGAAATCAC
CGTCACCGTCAGCGGTAAGGCGGTCGCACGCCTGACGGCCCTACAGCCTGCCCGGCGCAGATTGCTGAGTCGGGAGGAAT
TGCTACGACGGCTTGAGCGTGCACAGGCGGACCCAGCGTTGCGTGCGGAACTCGCCGAACTGGCGGGCGACACCACCGAT
GACCTCGGGTCGCCTTCGTGA