Detailed information of TA system TA036275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 391646..392648
• Replicon: chromosome
• Accession: NZ_AP022593
• Organism: Mycolicibacterium arabiense strain JCM 18538

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N61_RS03480
• Protein ID: WP_163917270.1
• Coordinates: 392070..392648 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: G6N61_RS03475
• Protein ID: WP_163917269.1
• Coordinates: 391646..392035 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N61_RS03460	387380..389062	+	1683	WP_163917267.1	alpha-amylase family protein	-
G6N61_RS03465	389014..391239	-	2226	WP_163924570.1	EAL domain-containing protein	-
G6N61_RS03470	391417..391551	-	135	WP_163917268.1	DUF2256 domain-containing protein	-
G6N61_RS03475	391646..392035	+	390	WP_163917269.1	hypothetical protein	Antitoxin
G6N61_RS03480	392070..392648	+	579	WP_163917270.1	zeta toxin family protein	Toxin
G6N61_RS03485	392735..394159	+	1425	WP_163917271.1	sugar porter family MFS transporter	-
G6N61_RS03490	394167..394460	-	294	WP_163917272.1	hypothetical protein	-
G6N61_RS03495	394460..394861	-	402	WP_163924571.1	hypothetical protein	-
G6N61_RS03500	394996..396585	-	1590	WP_163917273.1	threonine/serine exporter family protein	-
G6N61_RS03505	396670..396984	-	315	WP_198339324.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21176.52 Da
• Isoelectric Point: 10.9809

>T36275 WP_163917270.1 NZ_AP022593:392070-392648 [Mycolicibacterium arabiense]
VRRLDLVVGPNGAGKSTFVALTLAPLLPRSVFVNADEIAKQRWPDDPMGHAYDAARVAAETRARLIELGKPFIAETVFSH
PSKLELIRSARTAGFTVALHVVLIPEDLAVERVKRRVMHGGHDVPEGKIRERHRRLSELVVTAMPTVDTATVYDNSRRRG
PRIVAQMTAGTMIGAPSWPSWTPAPLVERWPA

Nucleotide

• Length: 579 bp

>T36275 NZ_AP022593:392070-392648 [Mycolicibacterium arabiense]
GTGAGGCGGCTCGATCTCGTCGTCGGTCCGAACGGTGCGGGTAAGTCGACCTTCGTCGCACTGACTCTGGCACCGCTGCT
GCCTCGCAGCGTGTTCGTCAACGCCGACGAGATCGCCAAGCAGCGCTGGCCGGACGATCCGATGGGCCACGCCTATGACG
CGGCGCGCGTCGCCGCCGAAACCCGGGCGAGACTCATCGAACTGGGCAAGCCCTTCATCGCCGAGACGGTGTTCTCGCAC
CCGTCGAAGCTCGAACTCATCCGCTCCGCACGCACGGCCGGGTTCACCGTCGCCCTGCACGTCGTACTCATCCCCGAGGA
CCTTGCAGTGGAGCGCGTGAAGCGCCGGGTGATGCACGGCGGACACGACGTGCCCGAGGGCAAGATCCGGGAACGGCACC
GCCGGCTGTCGGAACTGGTGGTGACGGCGATGCCCACGGTCGATACGGCGACGGTGTACGACAATTCGCGCCGACGGGGT
CCACGCATCGTTGCGCAGATGACCGCGGGAACGATGATCGGTGCACCGTCGTGGCCGTCCTGGACGCCGGCGCCGCTGGT
CGAGCGCTGGCCGGCTTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13777.16 Da
• Isoelectric Point: 4.2850

>AT36275 WP_163917269.1 NZ_AP022593:391646-392035 [Mycolicibacterium arabiense]
MANIADRVTRVAADLVESAAVEGARQSRSAKQQLDHWARVGRAVSSHQTASRHRVEAALAGDLDVTALADEEGVVFNAEI
SAAIEESLASTNYGDVLARRGITMVALDDDGEIVEYWPDGTSAVVRIDE

Nucleotide

• Length: 390 bp

>AT36275 NZ_AP022593:391646-392035 [Mycolicibacterium arabiense]
ATGGCGAACATCGCCGATCGTGTCACCAGGGTTGCTGCCGACCTCGTCGAGAGTGCAGCGGTCGAAGGCGCCCGCCAAAG
TCGTTCGGCCAAGCAGCAGCTCGATCACTGGGCTCGCGTCGGACGGGCGGTGTCCAGCCACCAGACCGCATCTCGTCACC
GCGTAGAAGCGGCACTGGCAGGCGATCTGGACGTGACCGCGCTGGCGGACGAAGAAGGCGTCGTCTTCAACGCTGAGATA
TCCGCCGCCATCGAGGAGAGTCTCGCCTCCACGAACTATGGGGACGTCCTCGCCCGACGTGGCATCACGATGGTTGCGCT
CGACGACGACGGTGAGATCGTCGAGTACTGGCCGGACGGCACGTCGGCCGTGGTGCGCATCGACGAGTGA