Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 3233172..3233800 Replicon chromosome
Accession NZ_AP022591
Organism Mycolicibacterium celeriflavum strain JCM 18439

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N18_RS15665 Protein ID WP_083000243.1
Coordinates 3233172..3233552 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N18_RS15670 Protein ID WP_109749356.1
Coordinates 3233582..3233800 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N18_RS15645 3228387..3229388 + 1002 WP_083000056.1 tripartite tricarboxylate transporter substrate binding protein -
G6N18_RS15650 3229385..3229930 + 546 WP_083000057.1 tripartite tricarboxylate transporter TctB family protein -
G6N18_RS15655 3229930..3231465 + 1536 WP_083000058.1 tripartite tricarboxylate transporter permease -
G6N18_RS15660 3231610..3233001 - 1392 WP_083000059.1 sodium:alanine symporter family protein -
G6N18_RS15665 3233172..3233552 - 381 WP_083000243.1 PIN domain-containing protein Toxin
G6N18_RS15670 3233582..3233800 - 219 WP_109749356.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G6N18_RS15675 3233869..3234942 - 1074 WP_083000060.1 zinc-binding dehydrogenase -
G6N18_RS15680 3234957..3236207 - 1251 WP_109749357.1 sulfotransferase -
G6N18_RS15685 3236204..3237280 - 1077 WP_179962441.1 DUF1214 domain-containing protein -
G6N18_RS15690 3237286..3237831 - 546 WP_083000062.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-117)

Antitoxin

Post-segregation antitoxin CcdA

(3-45)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13613.59 Da        Isoelectric Point: 5.9696

>T36272 WP_083000243.1 NZ_AP022591:c3233552-3233172 [Mycolicibacterium celeriflavum]
VVIDASAMVDLLARTHDRFAAVRARLAGTVMHAPAHFDAEVLSALGRMHRAGVLTDVQVEAALDELRQAPVTRHDLSPLL
AGAWGRRDVLRLTDALYVELADTADLVLLTTDQRLARAWPSADAIG

Download         Length: 381 bp

>T36272 NZ_AP022591:c3233552-3233172 [Mycolicibacterium celeriflavum]
GTGGTCATCGATGCCAGCGCCATGGTGGATCTACTTGCTCGTACGCACGATCGGTTCGCGGCGGTACGCGCACGATTGGC
CGGCACGGTGATGCACGCGCCGGCCCACTTTGACGCCGAGGTGTTATCGGCACTGGGGCGTATGCACCGCGCTGGCGTAC
TCACCGACGTTCAGGTCGAGGCCGCGCTTGACGAGCTGCGGCAGGCCCCGGTGACTCGGCACGATCTATCACCGCTGCTT
GCTGGAGCTTGGGGGCGCCGCGACGTCCTGCGCCTTACTGATGCCCTCTACGTCGAACTCGCCGACACTGCAGATCTGGT
GTTACTCACCACGGACCAGCGGTTGGCGCGTGCCTGGCCGTCGGCCGACGCCATCGGCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7788.53 Da        Isoelectric Point: 4.0680

>AT36272 WP_109749356.1 NZ_AP022591:c3233800-3233582 [Mycolicibacterium celeriflavum]
MARLNVYVPDDLAECARARGLNVSALTQAAIRAELENSATDAWLDGLEARSTDARHDDVLEAIDAARDEFGT

Download         Length: 219 bp

>AT36272 NZ_AP022591:c3233800-3233582 [Mycolicibacterium celeriflavum]
ATGGCTCGGTTGAACGTATATGTTCCGGACGATTTGGCAGAGTGCGCCAGGGCGCGGGGCCTGAACGTCTCGGCGCTGAC
TCAGGCCGCGATCCGGGCCGAATTGGAGAATTCTGCAACCGACGCCTGGCTCGATGGGCTGGAGGCCAGAAGCACAGACG
CCCGGCATGACGACGTGCTGGAGGCGATCGATGCCGCCCGCGATGAGTTCGGAACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References