Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5561781..5562463 Replicon chromosome
Accession NZ_AP022590
Organism Mycobacterium mantenii strain JCM 18113

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N50_RS25665 Protein ID WP_083098111.1
Coordinates 5561969..5562463 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N50_RS25660 Protein ID WP_083098110.1
Coordinates 5561781..5561966 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N50_RS25650 5557754..5559337 + 1584 WP_083098106.1 serine hydrolase -
G6N50_RS25655 5559334..5561715 + 2382 WP_083098108.1 cation-translocating P-type ATPase -
G6N50_RS25660 5561781..5561966 + 186 WP_083098110.1 antitoxin Antitoxin
G6N50_RS25665 5561969..5562463 + 495 WP_083098111.1 SRPBCC family protein Toxin
G6N50_RS25670 5562527..5563297 + 771 WP_083098113.1 VOC family protein -
G6N50_RS25675 5563344..5563778 + 435 WP_083098115.1 hypothetical protein -
G6N50_RS25680 5563783..5564274 - 492 WP_083098117.1 VOC family protein -
G6N50_RS25685 5564274..5565788 - 1515 WP_142275707.1 carotenoid oxygenase family protein -
G6N50_RS25690 5565791..5567017 - 1227 WP_083098121.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-140)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17817.49 Da        Isoelectric Point: 7.3604

>T36268 WP_083098111.1 NZ_AP022590:5561969-5562463 [Mycobacterium mantenii]
MAKLSGSIDVPLPPEVAWQHASDLSRFKDWLTIHRVWRSRLPDEIEKGTVVESIVEVKGMHNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLLAKIQPTVDGSIVSFDVHLGGPALFGPIGMIVAAALRGDINQSLENFVMVFTRPDPSTNGDGGSRRCGG
ADEF

Download         Length: 495 bp

>T36268 NZ_AP022590:5561969-5562463 [Mycobacterium mantenii]
ATGGCGAAGCTTTCCGGATCCATCGATGTCCCGCTGCCACCCGAGGTGGCCTGGCAGCATGCCTCCGACCTGTCCCGGTT
CAAGGACTGGCTGACCATCCACCGCGTGTGGCGCAGCAGATTGCCCGACGAGATCGAGAAGGGCACGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCACAACCGGATCAAGTGGACGGTGGTGCGCTACAAGCCGCCCGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGCTGGCGAAGATTCAGCCCACGGTCGACGGCTCCATCGTCAGCTTCGA
TGTGCACCTGGGCGGCCCGGCGCTGTTCGGCCCCATCGGCATGATCGTCGCCGCGGCCCTGCGCGGCGATATCAATCAGT
CGTTGGAGAACTTCGTAATGGTATTCACCCGGCCCGACCCGAGTACGAACGGAGACGGTGGGTCTCGTCGTTGCGGTGGC
GCCGATGAGTTTTAG

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6677.34 Da        Isoelectric Point: 4.2985

>AT36268 WP_083098110.1 NZ_AP022590:5561781-5561966 [Mycobacterium mantenii]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYTDTIQQVQEQARKATGAADTGDQQ

Download         Length: 186 bp

>AT36268 NZ_AP022590:5561781-5561966 [Mycobacterium mantenii]
ATGGGTTTCCTGGACAAGGCGAAGGACCTGCTGTCGCAGAACGCCGACAAGGTCGAGATGGCGATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACGCAGGGCAAGTACACCGACACCATTCAACAGGTGCAGGAGCAGGCCAGGAAGGCCACCGGCG
CCGCCGACACCGGCGACCAGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References