Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 4579760..4580417 Replicon chromosome
Accession NZ_AP022590
Organism Mycobacterium mantenii strain JCM 18113

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N50_RS20720 Protein ID WP_083094515.1
Coordinates 4580022..4580417 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N50_RS20715 Protein ID WP_197748074.1
Coordinates 4579760..4580017 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N50_RS20690 4575798..4576553 + 756 WP_083094518.1 enoyl-CoA hydratase/isomerase family protein -
G6N50_RS20695 4576600..4577397 + 798 WP_083094586.1 alpha/beta fold hydrolase -
G6N50_RS20700 4577357..4578458 + 1102 Protein_4105 NAD-dependent epimerase/dehydratase family protein -
G6N50_RS20705 4578584..4578841 - 258 WP_083094517.1 hypothetical protein -
G6N50_RS20710 4578838..4579455 - 618 WP_083094585.1 TetR/AcrR family transcriptional regulator -
G6N50_RS20715 4579760..4580017 + 258 WP_197748074.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N50_RS20720 4580022..4580417 + 396 WP_083094515.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N50_RS20725 4580889..4584389 - 3501 WP_083094514.1 indolepyruvate ferredoxin oxidoreductase family protein -
G6N50_RS20730 4584549..4585049 + 501 WP_083094513.1 Lrp/AsnC family transcriptional regulator -
G6N50_RS20735 4585091..4585216 - 126 WP_163650873.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-38)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13989.09 Da        Isoelectric Point: 5.8412

>T36267 WP_083094515.1 NZ_AP022590:4580022-4580417 [Mycobacterium mantenii]
MRIYLDTSALVKLVVAEDESQSLQSFLSARANDNLFSAALARTELIRAVAPNGAQAIADARDLLKSLDTVMLTRQLLDEA
GTLLPLRLRSLDAIHLVAAQRAGDSLRAVITYDARMLSAAADLGISAASPR

Download         Length: 396 bp

>T36267 NZ_AP022590:4580022-4580417 [Mycobacterium mantenii]
ATGCGGATCTACCTGGACACCTCTGCCTTGGTCAAACTCGTTGTCGCTGAGGATGAATCGCAGTCGCTGCAGTCCTTTCT
GAGCGCACGAGCTAACGACAATTTATTCTCGGCGGCTTTGGCGCGCACCGAGCTAATACGCGCAGTGGCACCAAACGGAG
CCCAAGCCATCGCTGATGCTCGAGACCTACTTAAGAGCTTGGACACCGTCATGCTGACGCGACAACTGCTCGACGAAGCC
GGCACCTTGCTGCCACTACGCTTGCGCAGCTTAGACGCTATACACCTCGTAGCGGCACAGCGAGCTGGCGACTCGTTGCG
CGCGGTCATCACATATGACGCGCGAATGCTTTCAGCAGCAGCGGATCTCGGGATCTCAGCAGCATCTCCGCGATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9330.46 Da        Isoelectric Point: 4.8380

>AT36267 WP_197748074.1 NZ_AP022590:4579760-4580017 [Mycobacterium mantenii]
IGVRELRQHASKYLEEVVAGESIEITDRGHPVARLVPITGDPWADLISAGEVVSAARPMNIDDLKPAAYPHSASETLERL
RSDER

Download         Length: 258 bp

>AT36267 NZ_AP022590:4579760-4580017 [Mycobacterium mantenii]
ATTGGGGTACGGGAGCTGCGGCAACACGCCAGCAAGTACCTTGAAGAAGTGGTCGCCGGGGAATCGATCGAGATCACTGA
CCGCGGCCACCCCGTCGCGCGCCTGGTGCCAATCACGGGCGATCCGTGGGCAGACCTGATTAGCGCTGGTGAAGTTGTCA
GCGCGGCTCGTCCGATGAACATCGACGACCTCAAGCCTGCGGCATACCCGCACAGCGCCTCTGAAACCCTTGAGCGACTT
CGGAGCGACGAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References