Detailed information of TA system TA036266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 1603078..1604076
• Replicon: chromosome
• Accession: NZ_AP022590
• Organism: Mycobacterium mantenii strain JCM 18113

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N50_RS07335
• Protein ID: WP_083092241.1
• Coordinates: 1603078..1603656 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A1A2TY14
• Locus tag: G6N50_RS07340
• Protein ID: WP_067826524.1
• Coordinates: 1603687..1604076 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N50_RS07310	1599143..1600069	-	927	WP_083092246.1	sigma-70 family RNA polymerase sigma factor	-
G6N50_RS07315	1600235..1600585	+	351	WP_083092245.1	DoxX family protein	-
G6N50_RS07320	1600607..1601407	-	801	WP_179970099.1	nuclear transport factor 2 family protein	-
G6N50_RS07325	1601407..1601967	-	561	WP_083092613.1	pyrazinamidase PncA	-
G6N50_RS07330	1602060..1603049	+	990	WP_083092243.1	DoxX family membrane protein	-
G6N50_RS07335	1603078..1603656	-	579	WP_083092241.1	zeta toxin family protein	Toxin
G6N50_RS07340	1603687..1604076	-	390	WP_067826524.1	hypothetical protein	Antitoxin
G6N50_RS07345	1604145..1604639	-	495	WP_083092239.1	gluconokinase	-
G6N50_RS07350	1604636..1606657	-	2022	WP_083092237.1	phosphotransferase	-
G6N50_RS07355	1606676..1608193	-	1518	WP_083092235.1	carboxylesterase/lipase family protein	-
G6N50_RS07360	1608273..1608950	+	678	WP_179970100.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-130)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21136.32 Da
• Isoelectric Point: 10.6694

>T36266 WP_083092241.1 NZ_AP022590:c1603656-1603078 [Mycobacterium mantenii]
MDRLDLVVGPNGAGKSTFIAFTLAPLLPGSLVVNADEIARQRWPQDAAAHSYDAARIAADTRAKLIDLGRSFIAETVFSH
PSKLDLIHAARRAGFTVVLHVVVIPEDLAVERVRHRVRAGGHDVPEGKIRQRHRRLWTPVAEAIALSDLTTVYDNSRLRG
PCIIARLSGGLTIGKPDWPAWAPEILRSRWPN

Nucleotide

• Length: 579 bp

>T36266 NZ_AP022590:c1603656-1603078 [Mycobacterium mantenii]
ATGGATCGACTCGACCTGGTCGTCGGGCCCAACGGTGCCGGCAAGTCGACGTTCATCGCGTTCACCTTGGCGCCGCTGTT
GCCGGGCAGCCTCGTGGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCCCAGGATGCGGCGGCACACTCCTACGACG
CCGCGCGCATCGCGGCCGACACCCGTGCAAAGCTGATCGACCTGGGCCGGTCCTTCATTGCCGAGACCGTGTTTTCCCAC
CCCTCGAAGCTGGACCTGATCCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTCCTGCACGTGGTTGTCATTCCGGAAGA
TCTTGCGGTCGAACGTGTCCGGCACCGCGTGCGAGCCGGCGGTCACGACGTGCCGGAAGGCAAGATCCGTCAGCGCCATC
GCCGGCTGTGGACGCCGGTCGCCGAGGCCATCGCCTTGTCCGATCTCACGACGGTCTACGACAACAGCCGCCTGCGCGGC
CCGTGCATCATCGCGCGGCTCAGCGGCGGGCTGACCATCGGCAAACCCGACTGGCCCGCGTGGGCGCCGGAGATCCTGCG
AAGCCGCTGGCCCAACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13464.88 Da
• Isoelectric Point: 4.7341

>AT36266 WP_067826524.1 NZ_AP022590:c1604076-1603687 [Mycobacterium mantenii]
MAEALDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLARTNYGATLAGQGVTTVALNDDGEIVEYRPDGAAVVLAGGR

Nucleotide

• Length: 390 bp

>AT36266 NZ_AP022590:c1604076-1603687 [Mycobacterium mantenii]
ATGGCGGAGGCCCTCGATCGTGTCACGCGGGTCGCGTCCGACCTGATGGACAGCGCGGCGGCGGAAGGCGCCCGGCAGAG
CCGCTCGGCCAAGCAGCAACTCGACCATTGGGCTCGGGTCGGGCGCGCAGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTGGAAGCCGCGCTCGCCGGCCAGCTCGCGACCGGCGAGCTCACCGTCGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCCATCGAAGAAAGCCTGGCGCGCACGAACTACGGGGCGACGCTGGCCGGGCAGGGCGTCACCACGGTCGCCCT
CAACGACGACGGCGAGATCGTCGAGTACCGTCCCGACGGCGCCGCGGTGGTGCTCGCGGGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1A2TY14