Detailed information of TA system TA036263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 5674843..5675615
• Replicon: chromosome
• Accession: NZ_AP022588
• Organism: Mycolicibacterium sediminis strain JCM 17899

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: G6N64_RS26945
• Protein ID: WP_163800846.1
• Coordinates: 5675109..5675615 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: G6N64_RS26940
• Protein ID: WP_163800845.1
• Coordinates: 5674843..5675112 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N64_RS29985	5670057..5670221	+	165	WP_174266889.1	hypothetical protein	-
G6N64_RS26915	5670425..5670835	-	411	WP_163802145.1	(deoxy)nucleoside triphosphate pyrophosphohydrolase	-
G6N64_RS26920	5671135..5671419	+	285	WP_163800842.1	4a-hydroxytetrahydrobiopterin dehydratase	-
G6N64_RS26925	5671397..5672596	-	1200	WP_163802146.1	mannosyltransferase	-
G6N64_RS26930	5672734..5673399	+	666	WP_163800843.1	hypothetical protein	-
G6N64_RS26935	5673461..5674525	+	1065	WP_163800844.1	hypothetical protein	-
G6N64_RS26940	5674843..5675112	+	270	WP_163800845.1	DUF1778 domain-containing protein	Antitoxin
G6N64_RS26945	5675109..5675615	+	507	WP_163800846.1	GNAT family N-acetyltransferase	Toxin
G6N64_RS26950	5675717..5675866	-	150	WP_163800847.1	DUF1059 domain-containing protein	-
G6N64_RS26955	5675973..5676551	-	579	WP_163800848.1	Fe-S cluster assembly protein HesB	-
G6N64_RS26960	5676608..5677822	+	1215	WP_163800849.1	histidine kinase	-
G6N64_RS26965	5677819..5678607	+	789	WP_163800850.1	LytTR family DNA-binding domain-containing protein	-
G6N64_RS26970	5678600..5678965	+	366	WP_163800851.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (35-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-82)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18151.76 Da
• Isoelectric Point: 6.8399

>T36263 WP_163800846.1 NZ_AP022588:5675109-5675615 [Mycolicibacterium sediminis]
VSVYSAPRPMSADDAVADFDSGEPSLDDYLRRRALANHVEGASRCFVTCRDAQVVGFYALSSAAVERAATPGRVRRNMPD
PVPVILLSRLAVDATHKGLGLGAHLLRDAITRAVAAAEIIGVRALIVHALHEQARALYAHFDFEPSPTDPLHLLLLIKDA
RALVDPDR

Nucleotide

• Length: 507 bp

>T36263 NZ_AP022588:5675109-5675615 [Mycolicibacterium sediminis]
GTGAGCGTCTACAGCGCGCCACGGCCGATGAGCGCGGACGACGCTGTCGCCGACTTCGATAGCGGCGAGCCCAGCCTGGA
CGATTATCTACGCAGGCGGGCGCTGGCCAACCACGTCGAGGGCGCCTCACGGTGTTTCGTGACCTGCCGCGACGCGCAGG
TCGTGGGGTTCTATGCGCTGTCCTCAGCGGCGGTCGAGCGTGCCGCAACACCGGGGCGGGTGCGCCGCAACATGCCAGAC
CCGGTGCCGGTTATCCTGCTGTCGCGGCTGGCGGTCGACGCCACGCACAAGGGTCTGGGCCTGGGGGCGCACCTCCTGCG
CGACGCGATCACCCGCGCCGTGGCGGCAGCGGAGATCATCGGCGTGCGGGCGCTTATCGTGCATGCCCTGCACGAGCAGG
CCCGCGCCTTGTATGCACACTTCGACTTCGAGCCCTCACCTACCGATCCGCTGCACCTGCTGCTGCTGATCAAGGACGCC
CGAGCCCTGGTCGATCCGGACAGGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10072.45 Da
• Isoelectric Point: 5.1532

>AT36263 WP_163800845.1 NZ_AP022588:5674843-5675112 [Mycolicibacterium sediminis]
MATKTERFAVRLTAEQDALIRRAAEVEGTDLTNFTVTATLAHARDVLADRRLFMLDASAWSEFVSVLDRAVSRKPRLEKL
FSEPSIFDE

Nucleotide

• Length: 270 bp

>AT36263 NZ_AP022588:5674843-5675112 [Mycolicibacterium sediminis]
ATGGCTACGAAGACGGAACGTTTCGCCGTGCGCCTGACCGCTGAGCAGGACGCGTTGATTCGTCGTGCCGCGGAGGTGGA
GGGGACAGATCTGACCAACTTCACGGTGACCGCGACGCTGGCTCATGCGCGCGACGTACTCGCCGATCGCCGGCTGTTCA
TGCTCGACGCCTCGGCGTGGTCGGAGTTCGTATCGGTCCTGGATCGCGCGGTGTCGCGCAAGCCACGGCTCGAGAAGTTG
TTCTCGGAGCCCTCGATCTTCGACGAGTGA