Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4523674..4524673 Replicon chromosome
Accession NZ_AP022588
Organism Mycolicibacterium sediminis strain JCM 17899

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N64_RS21630 Protein ID WP_163799633.1
Coordinates 4523674..4524249 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N64_RS21635 Protein ID WP_163799635.1
Coordinates 4524284..4524673 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N64_RS21600 4519908..4520273 - 366 WP_163799624.1 RNA-binding S4 domain-containing protein -
G6N64_RS21605 4520290..4521099 - 810 WP_163802002.1 Fpg/Nei family DNA glycosylase -
G6N64_RS21610 4521203..4521493 + 291 WP_163799626.1 antibiotic biosynthesis monooxygenase -
G6N64_RS21615 4521500..4521772 - 273 WP_163799628.1 YdeI/OmpD-associated family protein -
G6N64_RS21620 4521813..4522094 - 282 WP_163799630.1 hypothetical protein -
G6N64_RS21625 4522141..4523592 - 1452 WP_163799632.1 sugar porter family MFS transporter -
G6N64_RS21630 4523674..4524249 - 576 WP_163799633.1 AAA family ATPase Toxin
G6N64_RS21635 4524284..4524673 - 390 WP_163799635.1 hypothetical protein Antitoxin
G6N64_RS21640 4524748..4524882 + 135 WP_163799637.1 DUF2256 domain-containing protein -
G6N64_RS21645 4524901..4525533 - 633 WP_174266856.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
G6N64_RS21650 4525763..4526182 + 420 WP_163799639.1 NAD(+)--rifampin ADP-ribosyltransferase -
G6N64_RS21655 4526169..4526900 - 732 WP_163799641.1 hypothetical protein -
G6N64_RS21660 4526970..4528139 + 1170 WP_163799643.1 AI-2E family transporter -
G6N64_RS21665 4528133..4528828 - 696 WP_163799645.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20727.89 Da        Isoelectric Point: 10.5166

>T36262 WP_163799633.1 NZ_AP022588:c4524249-4523674 [Mycolicibacterium sediminis]
VTRLDLVVGPNGAGKSTFVALTLAPLLPRSVFVNADEIARQRWPADPMAHAYDAARVAAQTRAKLIELGTPFIAETVFSH
PSKLELVRTAQASGCTVALHVVLIPEDLAVERVRRRVLHGGHDVPEEKVRQRHRRLATLVAAASAMADTATVYDNSRRSG
PLIVAQLTAGMVVGSPTWPDWAPAPLRDRWP

Download         Length: 576 bp

>T36262 NZ_AP022588:c4524249-4523674 [Mycolicibacterium sediminis]
GTGACGCGGCTCGACCTCGTCGTCGGCCCCAACGGTGCGGGCAAGTCGACGTTCGTCGCGCTGACGCTCGCTCCCCTGCT
CCCCCGCAGCGTCTTCGTCAACGCCGACGAGATCGCGCGGCAGCGGTGGCCCGCCGACCCCATGGCGCACGCGTACGACG
CGGCGCGGGTCGCCGCGCAGACCCGTGCCAAGCTGATCGAACTGGGCACGCCGTTCATCGCCGAGACCGTCTTCTCCCAC
CCCTCGAAGCTCGAGCTGGTGCGCACCGCCCAGGCGTCCGGCTGCACCGTCGCACTGCACGTCGTCCTCATCCCCGAGGA
CCTCGCCGTCGAACGCGTCCGACGCCGGGTCCTGCACGGCGGCCACGACGTTCCCGAGGAGAAGGTCCGGCAGCGACACC
GACGGCTCGCGACGCTGGTCGCCGCCGCGTCGGCCATGGCCGACACCGCGACCGTCTACGACAACTCCCGGCGCAGCGGC
CCGCTCATCGTGGCCCAGCTGACCGCAGGAATGGTCGTCGGCTCACCGACCTGGCCGGACTGGGCGCCTGCACCGCTGCG
GGACCGGTGGCCCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13669.09 Da        Isoelectric Point: 4.5976

>AT36262 WP_163799635.1 NZ_AP022588:c4524673-4524284 [Mycolicibacterium sediminis]
VSSPTDRVTRVAADLVESATVEGARQSRSAKQQLDHWARVGRAVSSHQTASRRRVEAALAGTLKLTALDDDEGIVFGAEI
TAAIEERLATTNYGDVLAARGITMVALDDDGRIVEYWPDGSSSVVDTGA

Download         Length: 390 bp

>AT36262 NZ_AP022588:c4524673-4524284 [Mycolicibacterium sediminis]
GTGTCCAGTCCGACCGATCGCGTCACCCGGGTCGCCGCGGACCTCGTCGAAAGCGCCACGGTGGAGGGTGCGCGACAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCACGCGTGGGTCGTGCCGTGTCCAGTCACCAGACCGCCTCGCGGCGCC
GCGTCGAGGCGGCACTCGCCGGCACCCTCAAACTGACGGCGCTGGACGACGACGAGGGCATCGTGTTCGGTGCGGAGATC
ACCGCTGCGATCGAGGAGCGTCTCGCGACGACGAACTACGGCGACGTCCTCGCCGCCAGGGGCATCACCATGGTTGCGCT
CGACGACGACGGACGGATCGTCGAGTACTGGCCCGACGGCAGCTCGTCGGTGGTCGACACCGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References