Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4931571..4932236 Replicon chromosome
Accession NZ_AP022587
Organism Mycobacterium stomatepiae strain JCM 17783

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N54_RS23560 Protein ID WP_163792497.1
Coordinates 4931763..4932236 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N54_RS23555 Protein ID WP_163792496.1
Coordinates 4931571..4931759 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N54_RS23540 4926907..4927446 - 540 WP_197939554.1 G/U mismatch-specific DNA glycosylase -
G6N54_RS23545 4927491..4929071 + 1581 WP_163792494.1 serine hydrolase -
G6N54_RS23550 4929068..4931467 + 2400 WP_163792495.1 cation-translocating P-type ATPase -
G6N54_RS23555 4931571..4931759 + 189 WP_163792496.1 antitoxin Antitoxin
G6N54_RS23560 4931763..4932236 + 474 WP_163792497.1 SRPBCC family protein Toxin
G6N54_RS23565 4932275..4932424 + 150 Protein_4682 VOC family protein -
G6N54_RS23570 4932567..4933001 + 435 WP_163792499.1 hypothetical protein -
G6N54_RS23575 4933006..4933491 - 486 WP_163792501.1 VOC family protein -
G6N54_RS23580 4933529..4935043 - 1515 WP_163792503.1 carotenoid oxygenase family protein -
G6N54_RS23585 4935045..4936271 - 1227 WP_163792505.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17003.68 Da        Isoelectric Point: 9.5659

>T36261 WP_163792497.1 NZ_AP022587:4931763-4932236 [Mycobacterium stomatepiae]
MAKLSGAIDVPLSPEQAWTHASDLSRYKDWLSIHRVWRSQLPDNLEKGTVIESIVEVKGMLNRIKWTIVHYKPPEAMTLN
GVGVGGVKVKLIAKVKPNDAGSIVSFDVHLGGPALFGPIGMIVAAALRSDIDESLERFVTVFTAPDPGRNGHGITGR

Download         Length: 474 bp

>T36261 NZ_AP022587:4931763-4932236 [Mycobacterium stomatepiae]
ATGGCGAAACTTTCCGGAGCCATCGACGTACCGCTGTCGCCCGAGCAGGCCTGGACGCATGCCTCCGATCTGTCCCGCTA
CAAGGACTGGCTGAGCATCCACCGGGTGTGGCGCAGCCAGCTGCCCGACAACCTGGAAAAGGGCACCGTGATCGAATCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGATCGTGCACTACAAGCCGCCGGAAGCCATGACGCTCAAC
GGTGTCGGCGTCGGCGGGGTCAAGGTCAAACTGATCGCGAAGGTCAAGCCGAACGACGCCGGATCGATCGTCAGCTTCGA
CGTTCACCTCGGTGGCCCAGCGTTGTTCGGCCCGATCGGCATGATCGTTGCGGCGGCATTGCGAAGTGACATCGACGAGT
CCCTGGAAAGATTCGTCACGGTGTTCACCGCTCCCGATCCCGGTCGCAACGGACATGGGATTACCGGTCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6667.34 Da        Isoelectric Point: 4.9849

>AT36261 WP_163792496.1 NZ_AP022587:4931571-4931759 [Mycobacterium stomatepiae]
MGFLDKAKDLLAQNADKVETAIDKAGEFVDDKTQGKYSDTIHKVQEEAKKAAGSQAQGNQQG

Download         Length: 189 bp

>AT36261 NZ_AP022587:4931571-4931759 [Mycobacterium stomatepiae]
ATGGGATTCCTGGACAAGGCAAAGGACCTGTTGGCGCAGAACGCCGACAAGGTCGAGACCGCGATTGACAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGGAAGTACTCCGACACCATCCACAAGGTGCAGGAAGAGGCCAAGAAGGCCGCTGGCT
CTCAGGCTCAGGGCAACCAGCAGGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References