Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5384410..5385075 Replicon chromosome
Accession NZ_AP022586
Organism Mycolicibacterium litorale strain JCM 17423

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N30_RS25935 Protein ID WP_134056121.1
Coordinates 5384632..5385075 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N30_RS25930 Protein ID WP_134056124.1
Coordinates 5384410..5384628 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N30_RS25920 5380374..5381966 + 1593 WP_134056130.1 serine hydrolase -
G6N30_RS25925 5382009..5384399 + 2391 WP_134056127.1 cation-translocating P-type ATPase -
G6N30_RS25930 5384410..5384628 + 219 WP_134056124.1 antitoxin Antitoxin
G6N30_RS25935 5384632..5385075 + 444 WP_134056121.1 SRPBCC family protein Toxin
G6N30_RS25940 5385072..5385467 - 396 WP_134056119.1 hypothetical protein -
G6N30_RS25945 5385486..5386175 - 690 WP_134056117.1 hypothetical protein -
G6N30_RS25950 5386314..5387111 - 798 WP_134056114.1 CbbQ/NirQ/NorQ/GpvN family protein -
G6N30_RS25955 5387108..5388640 - 1533 WP_134056112.1 MorD protein -
G6N30_RS25960 5388801..5389448 - 648 WP_134057472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-144)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15967.59 Da        Isoelectric Point: 9.5321

>T36258 WP_134056121.1 NZ_AP022586:5384632-5385075 [Mycolicibacterium litorale]
MAKLSVSVDVPLPPEKAWECASDLSRYKEWLSIHRVWRSKLPETLDKGAQIDSIVEVMGMATRVHWTIVHYKPPQAMTLN
GDGKGGVKVKLLGKVKPSETGDGSTVTFDIHLGGPALFGPIGMVVAGALKSDIRESLERFKSVFAPA

Download         Length: 444 bp

>T36258 NZ_AP022586:5384632-5385075 [Mycolicibacterium litorale]
ATGGCCAAACTGTCCGTCTCCGTCGATGTCCCACTACCGCCGGAGAAGGCGTGGGAGTGCGCCTCCGATCTGTCGCGGTA
CAAGGAATGGCTGTCCATCCACCGGGTGTGGCGGTCGAAGCTGCCCGAAACGCTGGACAAGGGCGCCCAGATCGACTCCA
TCGTCGAGGTGATGGGGATGGCCACCCGCGTGCACTGGACCATCGTCCATTACAAGCCGCCGCAGGCGATGACGCTCAAC
GGCGACGGCAAGGGCGGGGTGAAGGTGAAGCTGCTGGGGAAGGTGAAGCCGTCGGAGACCGGTGACGGTTCGACCGTCAC
CTTCGACATCCACCTCGGTGGGCCCGCGCTGTTCGGGCCGATCGGCATGGTGGTCGCCGGCGCCCTCAAGAGCGACATCC
GTGAGTCGCTGGAGAGGTTCAAGTCGGTCTTCGCGCCTGCCTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7907.86 Da        Isoelectric Point: 10.4155

>AT36258 WP_134056124.1 NZ_AP022586:5384410-5384628 [Mycolicibacterium litorale]
MAFLDKVKNWVSKNPDKAGSAIEKAGDLFDQKTQGRYSDKVNKAQSAARNYVDKNTPPGQGPINPPQPPRQP

Download         Length: 219 bp

>AT36258 NZ_AP022586:5384410-5384628 [Mycolicibacterium litorale]
ATGGCATTCCTCGACAAAGTGAAGAACTGGGTGTCGAAGAACCCCGACAAGGCCGGCAGCGCGATCGAGAAGGCCGGCGA
CCTCTTCGACCAGAAGACGCAGGGGCGCTACTCCGACAAGGTGAACAAGGCCCAGAGCGCGGCCCGCAACTACGTCGACA
AGAACACCCCGCCCGGCCAGGGCCCCATCAACCCTCCGCAGCCGCCGAGGCAGCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References