Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1809700..1810686 Replicon chromosome
Accession NZ_AP022586
Organism Mycolicibacterium litorale strain JCM 17423

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N30_RS08390 Protein ID WP_134051785.1
Coordinates 1809700..1810278 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N30_RS08395 Protein ID WP_134051787.1
Coordinates 1810294..1810686 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N30_RS08375 1806167..1807768 + 1602 WP_134051777.1 HAMP domain-containing protein -
G6N30_RS08380 1807815..1808339 + 525 WP_134051780.1 hypothetical protein -
G6N30_RS08385 1808308..1809501 + 1194 WP_134051782.1 type III PLP-dependent enzyme -
G6N30_RS08390 1809700..1810278 - 579 WP_134051785.1 zeta toxin family protein Toxin
G6N30_RS08395 1810294..1810686 - 393 WP_134051787.1 hypothetical protein Antitoxin
G6N30_RS08400 1810836..1811702 + 867 WP_179965564.1 EamA family transporter -
G6N30_RS08405 1811717..1812478 - 762 WP_134051790.1 SDR family oxidoreductase -
G6N30_RS08410 1812489..1813502 - 1014 WP_134051793.1 acetamidase/formamidase family protein -
G6N30_RS08415 1813609..1814025 + 417 WP_179965565.1 pyridoxamine 5'-phosphate oxidase family protein -
G6N30_RS08420 1814035..1814619 - 585 WP_134055068.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
G6N30_RS08425 1814712..1815317 - 606 WP_134051799.1 class I SAM-dependent methyltransferase -
G6N30_RS08430 1815401..1815625 + 225 WP_134051801.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21199.25 Da        Isoelectric Point: 9.9512

>T36256 WP_134051785.1 NZ_AP022586:c1810278-1809700 [Mycolicibacterium litorale]
MRRLDLVVGPNGAGKSTFVAFTLAPLLPASPFVNADEIARQRWPTDAEHHSYEAARIAAATRTALIDAGRSFIAETVFSH
PSKLDLIAEAHARDYTVVLHVLLIPEELAVERVKHRVLAGGHNVAEDKIRERHRRLWDHVVRAIGFCDSATVYDNSRRKG
PRIVAQFAGGSPIGSPGWPAWAPLPLQKQWPV

Download         Length: 579 bp

>T36256 NZ_AP022586:c1810278-1809700 [Mycolicibacterium litorale]
ATGCGCCGACTCGACCTCGTCGTCGGACCCAACGGCGCGGGCAAGTCCACCTTCGTCGCGTTCACCCTGGCTCCGCTGCT
GCCGGCTAGCCCGTTCGTCAACGCCGACGAGATCGCCCGGCAACGCTGGCCCACCGATGCCGAGCACCACTCCTATGAGG
CCGCGCGAATCGCCGCCGCCACGCGCACCGCGCTGATCGATGCCGGGCGCTCGTTCATCGCCGAAACCGTCTTCTCCCAT
CCATCCAAACTCGACCTCATCGCCGAGGCGCACGCCCGGGACTACACCGTCGTCCTGCACGTCCTGCTGATCCCCGAAGA
GCTGGCGGTCGAACGTGTCAAGCACCGGGTGCTCGCGGGCGGGCACAACGTCGCCGAAGACAAGATCCGGGAACGCCACC
GCCGCTTGTGGGATCACGTGGTGCGCGCCATCGGGTTCTGCGACAGCGCGACCGTCTACGACAACAGCCGCCGTAAAGGG
CCGCGAATCGTCGCGCAGTTCGCCGGTGGCAGCCCGATCGGATCCCCCGGTTGGCCCGCCTGGGCTCCGCTGCCCCTGCA
GAAGCAGTGGCCGGTCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13654.00 Da        Isoelectric Point: 4.9045

>AT36256 WP_134051787.1 NZ_AP022586:c1810686-1810294 [Mycolicibacterium litorale]
MADVADRVTRVAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGQTDPSSLNREEGVVFNAEI
SAAIEEQLAGADYGSLLAARGVTTVALDDAGRIVQYRPDGTSVVLDDPSS

Download         Length: 393 bp

>AT36256 NZ_AP022586:c1810686-1810294 [Mycolicibacterium litorale]
ATGGCCGATGTCGCCGACCGGGTGACCCGCGTCGCCGCGGATTTGATCGACAGCGCGGCCGCAGAAGGTGCCCGACAGAG
CCGCTCGGCCAAACAGCAACTCGACCACTGGGCACGGGTCGGCCGAGCCGTGTCGAGCCACCACACCGCCGCGCGTCGGC
GGGTGGAGGCCGCGCTGGCCGGGCAGACCGATCCGAGCAGCCTGAACCGGGAAGAGGGCGTTGTGTTCAACGCCGAGATC
TCCGCGGCGATCGAGGAGCAACTCGCCGGCGCAGACTACGGAAGTCTGCTGGCCGCGCGCGGCGTCACCACCGTCGCACT
CGACGACGCCGGACGGATCGTCCAGTACCGGCCCGACGGGACGTCGGTCGTCCTCGACGACCCGTCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References