Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4760665..4761318 Replicon chromosome
Accession NZ_AP022584
Organism Mycobacterium marseillense strain JCM 17324

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A1A3JRV9
Locus tag G6N26_RS22330 Protein ID WP_067167921.1
Coordinates 4760857..4761318 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A1A3JUV6
Locus tag G6N26_RS22325 Protein ID WP_067167924.1
Coordinates 4760665..4760853 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N26_RS22315 4756632..4758215 + 1584 WP_083017980.1 serine hydrolase -
G6N26_RS22320 4758212..4760599 + 2388 WP_083017982.1 cation-translocating P-type ATPase -
G6N26_RS22325 4760665..4760853 + 189 WP_067167924.1 antitoxin Antitoxin
G6N26_RS22330 4760857..4761318 + 462 WP_067167921.1 SRPBCC family protein Toxin
G6N26_RS22335 4761403..4762173 + 771 WP_083018074.1 VOC family protein -
G6N26_RS22340 4762248..4762682 + 435 WP_083017984.1 hypothetical protein -
G6N26_RS22345 4762687..4763175 - 489 WP_083017986.1 VOC family protein -
G6N26_RS22350 4763175..4764689 - 1515 WP_083017989.1 carotenoid oxygenase family protein -
G6N26_RS22355 4764692..4765912 - 1221 WP_083017991.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16724.22 Da        Isoelectric Point: 8.5214

>T36255 WP_067167921.1 NZ_AP022584:4760857-4761318 [Mycobacterium marseillense]
MAKLSGSIDVPLPPEVAWQYASDLSRYKDWLTIHRVWRSTLPDEIEKGSVVESIVEVKGMHNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPNGDGSIVSFDVHLGGPALFGPIGMIVAAALRGDINQSLENFVTVFTRSDPSTNGHR

Download         Length: 462 bp

>T36255 NZ_AP022584:4760857-4761318 [Mycobacterium marseillense]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCACCCGAGGTGGCCTGGCAGTACGCCTCCGATCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGCGTGTGGCGCAGCACATTGCCCGACGAGATCGAAAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCACAACCGGATCAAATGGACGGTCGTGCGTTATAAGCCCCCCGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGTGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAATGGGGACGGCTCCATCGTCAGCTTCGA
CGTGCACCTCGGCGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCGGCGGCACTGCGCGGCGACATCAACCAGT
CGCTGGAGAACTTCGTCACGGTCTTCACCCGATCCGATCCGAGCACCAACGGGCATCGGTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6780.47 Da        Isoelectric Point: 4.4702

>AT36255 WP_067167924.1 NZ_AP022584:4760665-4760853 [Mycobacterium marseillense]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGPADPGDQQN

Download         Length: 189 bp

>AT36255 NZ_AP022584:4760665-4760853 [Mycobacterium marseillense]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCTGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACGCAGGGCAAATACTCCGACACCATCCACCAGGTGCAGGAGCAAGCGAAGAAGGCCACCGGGC
CCGCGGACCCGGGCGACCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A3JRV9

Antitoxin

Source ID Structure
AlphaFold DB A0A1A3JUV6

References