Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 773770..774762 Replicon chromosome
Accession NZ_AP022584
Organism Mycobacterium marseillense strain JCM 17324

Toxin (Protein)


Gene name pezT Uniprot ID A0A1A3JKZ4
Locus tag G6N26_RS03395 Protein ID WP_067169891.1
Coordinates 774184..774762 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1A3JJ40
Locus tag G6N26_RS03390 Protein ID WP_067169894.1
Coordinates 773770..774159 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N26_RS03370 768901..769581 - 681 WP_179960283.1 hypothetical protein -
G6N26_RS03375 769661..771178 + 1518 WP_067169904.1 carboxylesterase/lipase family protein -
G6N26_RS03380 771197..773209 + 2013 WP_083017105.1 phosphotransferase -
G6N26_RS03385 773206..773700 + 495 WP_067169898.1 gluconokinase -
G6N26_RS03390 773770..774159 + 390 WP_067169894.1 hypothetical protein Antitoxin
G6N26_RS03395 774184..774762 + 579 WP_067169891.1 zeta toxin family protein Toxin
G6N26_RS03400 774839..775906 - 1068 WP_067169888.1 DoxX family membrane protein -
G6N26_RS03405 776002..776562 + 561 WP_155524097.1 pyrazinamidase PncA -
G6N26_RS03410 776562..777362 + 801 WP_083017109.1 nuclear transport factor 2 family protein -
G6N26_RS03415 777374..777724 - 351 WP_067169877.1 DoxX family protein -
G6N26_RS03420 777890..778861 + 972 WP_145012770.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-140)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21125.21 Da        Isoelectric Point: 11.0157

>T36254 WP_067169891.1 NZ_AP022584:774184-774762 [Mycobacterium marseillense]
MQRLDLVVGPNGAGKSTFIAFTLARLLPGSLVVNADEIARQRWPEEPAGHAYDAARIAAETRAKLIDLGRSLIAETVFSH
PSKLDLIHSARRAGFSVIVHALLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTEAVALADIATVYDNSRLRG
PRIVARLSGGMTVGRPDWPAWTPGTLGSRWTD

Download         Length: 579 bp

>T36254 NZ_AP022584:774184-774762 [Mycobacterium marseillense]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCGACTGCT
GCCCGGCAGCCTGGTGGTCAACGCCGACGAAATCGCTAGGCAGCGCTGGCCGGAGGAGCCGGCGGGGCACGCCTACGACG
CCGCGCGAATCGCCGCCGAGACCCGCGCGAAGCTGATCGACCTGGGGCGGTCGCTCATCGCGGAGACCGTGTTCTCCCAC
CCGTCGAAGCTCGACCTCATCCACTCCGCCCGCCGCGCGGGCTTCAGCGTCATCGTGCACGCATTGCTCATCCCGGAAGA
CCTCGCCGTCGAACGTGTCCGGCACCGCGTGCGCGCCGGCGGCCATGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GCCGCTTATGGACACCGGTCACCGAGGCCGTCGCGCTGGCCGACATCGCCACCGTCTACGACAACAGCCGCCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCAGCGGCGGCATGACGGTCGGTCGCCCCGACTGGCCGGCGTGGACGCCAGGGACCCTGGG
GTCACGCTGGACGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13526.92 Da        Isoelectric Point: 5.1725

>AT36254 WP_067169894.1 NZ_AP022584:773770-774159 [Mycobacterium marseillense]
MPDAPDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLPTGELTVEEGVVFNAEI
SAAIEESLAHTNYGATLAGQGVTTVALNDDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT36254 NZ_AP022584:773770-774159 [Mycobacterium marseillense]
ATGCCCGACGCTCCCGATCGCGTCACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGCCAGAG
CCGGTCGGCCAAGCAGCAACTCGACCACTGGGCGCGGGTCGGGCGGGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTTGAGGCCGCGCTCGCCGGCCAGCTGCCGACCGGCGAACTGACCGTCGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCCATCGAAGAAAGCCTGGCGCACACCAACTACGGGGCGACGCTGGCGGGGCAGGGAGTCACCACGGTCGCCCT
CAACGACGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A3JKZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1A3JJ40

References