Detailed information of TA system TA036254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 773770..774762
• Replicon: chromosome
• Accession: NZ_AP022584
• Organism: Mycobacterium marseillense strain JCM 17324

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A1A3JKZ4
• Locus tag: G6N26_RS03395
• Protein ID: WP_067169891.1
• Coordinates: 774184..774762 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A1A3JJ40
• Locus tag: G6N26_RS03390
• Protein ID: WP_067169894.1
• Coordinates: 773770..774159 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N26_RS03370	768901..769581	-	681	WP_179960283.1	hypothetical protein	-
G6N26_RS03375	769661..771178	+	1518	WP_067169904.1	carboxylesterase/lipase family protein	-
G6N26_RS03380	771197..773209	+	2013	WP_083017105.1	phosphotransferase	-
G6N26_RS03385	773206..773700	+	495	WP_067169898.1	gluconokinase	-
G6N26_RS03390	773770..774159	+	390	WP_067169894.1	hypothetical protein	Antitoxin
G6N26_RS03395	774184..774762	+	579	WP_067169891.1	zeta toxin family protein	Toxin
G6N26_RS03400	774839..775906	-	1068	WP_067169888.1	DoxX family membrane protein	-
G6N26_RS03405	776002..776562	+	561	WP_155524097.1	pyrazinamidase PncA	-
G6N26_RS03410	776562..777362	+	801	WP_083017109.1	nuclear transport factor 2 family protein	-
G6N26_RS03415	777374..777724	-	351	WP_067169877.1	DoxX family protein	-
G6N26_RS03420	777890..778861	+	972	WP_145012770.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-140)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21125.21 Da
• Isoelectric Point: 11.0157

>T36254 WP_067169891.1 NZ_AP022584:774184-774762 [Mycobacterium marseillense]
MQRLDLVVGPNGAGKSTFIAFTLARLLPGSLVVNADEIARQRWPEEPAGHAYDAARIAAETRAKLIDLGRSLIAETVFSH
PSKLDLIHSARRAGFSVIVHALLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTEAVALADIATVYDNSRLRG
PRIVARLSGGMTVGRPDWPAWTPGTLGSRWTD

Nucleotide

• Length: 579 bp

>T36254 NZ_AP022584:774184-774762 [Mycobacterium marseillense]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCGACTGCT
GCCCGGCAGCCTGGTGGTCAACGCCGACGAAATCGCTAGGCAGCGCTGGCCGGAGGAGCCGGCGGGGCACGCCTACGACG
CCGCGCGAATCGCCGCCGAGACCCGCGCGAAGCTGATCGACCTGGGGCGGTCGCTCATCGCGGAGACCGTGTTCTCCCAC
CCGTCGAAGCTCGACCTCATCCACTCCGCCCGCCGCGCGGGCTTCAGCGTCATCGTGCACGCATTGCTCATCCCGGAAGA
CCTCGCCGTCGAACGTGTCCGGCACCGCGTGCGCGCCGGCGGCCATGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GCCGCTTATGGACACCGGTCACCGAGGCCGTCGCGCTGGCCGACATCGCCACCGTCTACGACAACAGCCGCCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCAGCGGCGGCATGACGGTCGGTCGCCCCGACTGGCCGGCGTGGACGCCAGGGACCCTGGG
GTCACGCTGGACGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13526.92 Da
• Isoelectric Point: 5.1725

>AT36254 WP_067169894.1 NZ_AP022584:773770-774159 [Mycobacterium marseillense]
MPDAPDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLPTGELTVEEGVVFNAEI
SAAIEESLAHTNYGATLAGQGVTTVALNDDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT36254 NZ_AP022584:773770-774159 [Mycobacterium marseillense]
ATGCCCGACGCTCCCGATCGCGTCACCCGGGTGGCGTCCGACCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGCCAGAG
CCGGTCGGCCAAGCAGCAACTCGACCACTGGGCGCGGGTCGGGCGGGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTTGAGGCCGCGCTCGCCGGCCAGCTGCCGACCGGCGAACTGACCGTCGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCCATCGAAGAAAGCCTGGCGCACACCAACTACGGGGCGACGCTGGCGGGGCAGGGAGTCACCACGGTCGCCCT
CAACGACGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGACGCTGA

Structures

Toxin

• AlphaFold DB: A0A1A3JKZ4

Antitoxin

• AlphaFold DB: A0A1A3JJ40