Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2588096..2588700 Replicon chromosome
Accession NZ_AP022583
Organism Mycobacterium noviomagense strain JCM 16367

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N15_RS11980 Protein ID WP_163748053.1
Coordinates 2588302..2588700 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N15_RS11975 Protein ID WP_197910664.1
Coordinates 2588096..2588305 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N15_RS11955 2584055..2584522 - 468 WP_083088676.1 SEC-C domain-containing protein -
G6N15_RS11960 2584519..2584677 - 159 WP_163748051.1 hypothetical protein -
G6N15_RS11965 2584793..2585662 + 870 WP_179961742.1 hypothetical protein -
G6N15_RS11970 2585737..2588058 + 2322 WP_179961743.1 GH92 family glycosyl hydrolase -
G6N15_RS11975 2588096..2588305 + 210 WP_197910664.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N15_RS11980 2588302..2588700 + 399 WP_163748053.1 PIN domain nuclease Toxin
G6N15_RS11985 2588779..2589075 + 297 WP_083088678.1 toxin-antitoxin system HicB family antitoxin -
G6N15_RS11990 2589072..2589506 + 435 WP_083088679.1 type II toxin-antitoxin system VapC family toxin -
G6N15_RS11995 2589506..2589685 + 180 WP_083088680.1 hypothetical protein -
G6N15_RS12000 2589870..2590670 + 801 WP_083088681.1 hypothetical protein -
G6N15_RS12005 2590860..2591456 + 597 WP_083088682.1 hypothetical protein -
G6N15_RS12010 2591467..2591631 + 165 Protein_2384 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(5-46)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14566.83 Da        Isoelectric Point: 5.1863

>T36248 WP_163748053.1 NZ_AP022583:2588302-2588700 [Mycobacterium noviomagense]
VIVVDTSVWIDVLNDSPTPHAQRCVELIESGEPVALTDVVLTETLQGLRSDREAALVEQHLRAFPILRLKDLDDFVLAAK
LYRAARRAGVTIRKTLDCLIAAPCVRTGAPLLHADEDFDRLANCTPLRIWAG

Download         Length: 399 bp

>T36248 NZ_AP022583:2588302-2588700 [Mycobacterium noviomagense]
GTGATCGTCGTCGACACCAGCGTGTGGATCGACGTCCTGAACGACAGCCCCACACCGCATGCCCAGCGTTGCGTTGAGCT
CATTGAATCAGGAGAACCTGTCGCGCTCACCGACGTCGTCCTCACCGAAACTCTGCAGGGGCTGCGGTCGGATCGGGAGG
CGGCCCTAGTGGAACAGCATCTGCGTGCCTTCCCCATCCTTCGCCTGAAGGATCTTGATGATTTTGTTCTCGCGGCAAAG
TTGTATCGCGCGGCGCGGCGCGCCGGCGTGACTATCCGTAAGACTCTCGACTGTTTGATCGCCGCTCCTTGCGTGCGTAC
CGGTGCTCCGCTTCTGCATGCCGACGAGGACTTCGACCGGCTTGCTAACTGCACACCACTTCGGATCTGGGCAGGCTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7999.21 Da        Isoelectric Point: 10.6577

>AT36248 WP_197910664.1 NZ_AP022583:2588096-2588305 [Mycobacterium noviomagense]
MLMCMRTNIDIDDDVLREAQRLVGTRTKRDTVNLALRELVARHRQIGVLDLRGKVHWDGDLAESRRGRS

Download         Length: 210 bp

>AT36248 NZ_AP022583:2588096-2588305 [Mycobacterium noviomagense]
ATGCTGATGTGTATGCGGACGAACATTGACATCGACGACGACGTCCTGCGGGAGGCGCAGCGCCTGGTCGGGACCCGGAC
GAAGCGCGACACGGTGAACCTGGCGCTGCGCGAACTTGTCGCCCGGCATCGCCAGATCGGCGTCCTAGACCTACGGGGGA
AGGTGCACTGGGACGGCGACCTGGCCGAGAGTCGTCGCGGCCGCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References