Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1251543..1252207 Replicon chromosome
Accession NZ_AP022583
Organism Mycobacterium noviomagense strain JCM 16367

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N15_RS05850 Protein ID WP_083085426.1
Coordinates 1251543..1251965 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N15_RS05855 Protein ID WP_083085428.1
Coordinates 1251962..1252207 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N15_RS05835 1247367..1248461 + 1095 WP_083085418.1 acyl-CoA/acyl-ACP dehydrogenase -
G6N15_RS05840 1248465..1249973 + 1509 WP_083085421.1 long-chain-fatty-acid--CoA ligase FadD17 -
G6N15_RS05845 1250000..1251484 + 1485 WP_083085424.1 NAD(P)/FAD-dependent oxidoreductase -
G6N15_RS05850 1251543..1251965 - 423 WP_083085426.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N15_RS05855 1251962..1252207 - 246 WP_083085428.1 plasmid stabilization protein Antitoxin
G6N15_RS05860 1252254..1253702 - 1449 WP_083085593.1 aldehyde dehydrogenase -
G6N15_RS05865 1253799..1255064 + 1266 WP_083085430.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
G6N15_RS05870 1255069..1255398 + 330 WP_083085431.1 hypothetical protein -
G6N15_RS05875 1255395..1256633 + 1239 WP_083085432.1 amidohydrolase family protein -
G6N15_RS05880 1256641..1257099 + 459 WP_083085433.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15038.10 Da        Isoelectric Point: 4.2999

>T36244 WP_083085426.1 NZ_AP022583:c1251965-1251543 [Mycobacterium noviomagense]
MIVLDTNVVSELMRKAPDPGVVQWVDAFDASDVFITAVTAAELMYGVSWLPEGRRKRDLFSKVGALLVEDFAEQILPFDG
PAAVHYADIVASRELAGRPISMADAQTAAICRQWSAGVATRNAADFEGTGIQVVNPWGGT

Download         Length: 423 bp

>T36244 NZ_AP022583:c1251965-1251543 [Mycobacterium noviomagense]
TTGATCGTTCTCGACACCAACGTTGTATCCGAATTGATGCGCAAGGCACCAGACCCTGGTGTGGTGCAATGGGTGGACGC
ATTTGACGCGTCGGACGTGTTCATAACCGCAGTGACGGCGGCAGAACTGATGTACGGCGTCTCATGGCTGCCAGAAGGGC
GCCGCAAGCGGGACTTGTTCTCCAAAGTTGGTGCGCTGCTGGTGGAAGATTTTGCCGAGCAGATTCTGCCCTTCGATGGG
CCGGCAGCAGTCCACTATGCCGACATCGTCGCGTCAAGGGAATTGGCTGGACGGCCGATCAGTATGGCGGATGCACAGAC
CGCGGCAATTTGTCGGCAGTGGAGTGCTGGCGTAGCGACGCGCAACGCCGCCGACTTCGAAGGCACAGGCATCCAAGTGG
TCAACCCGTGGGGTGGCACGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8931.32 Da        Isoelectric Point: 11.2826

>AT36244 WP_083085428.1 NZ_AP022583:c1252207-1251962 [Mycobacterium noviomagense]
MATLTIRDLDDELKAALRVRAAKKGRSMEAEVREILRAVLTRPSSGIGMGTRIRQRFSGGENAEIELPARTELPRAAELR
G

Download         Length: 246 bp

>AT36244 NZ_AP022583:c1252207-1251962 [Mycobacterium noviomagense]
ATGGCAACCTTGACGATCCGCGACTTGGATGACGAACTCAAAGCGGCGCTACGTGTGCGTGCCGCGAAGAAGGGCCGATC
CATGGAAGCAGAGGTGCGCGAGATCTTGCGAGCAGTGCTGACGCGTCCGTCGTCCGGCATCGGGATGGGAACTCGGATTC
GGCAGCGGTTCTCCGGCGGCGAGAACGCGGAGATTGAACTTCCCGCGCGCACTGAGCTTCCGCGAGCCGCGGAGCTTCGT
GGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References