Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 922950..923635 Replicon chromosome
Accession NZ_AP022583
Organism Mycobacterium noviomagense strain JCM 16367

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N15_RS04135 Protein ID WP_083087164.1
Coordinates 923240..923635 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N15_RS04130 Protein ID WP_083087165.1
Coordinates 922950..923180 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N15_RS04110 918518..919594 + 1077 WP_083087169.1 diacylglycerol kinase -
G6N15_RS04115 919633..920865 + 1233 WP_083087168.1 Nramp family divalent metal transporter -
G6N15_RS04120 920963..922030 + 1068 WP_083087167.1 poly-gamma-glutamate hydrolase family protein -
G6N15_RS04125 922046..922858 + 813 WP_083087166.1 LLM class F420-dependent oxidoreductase -
G6N15_RS04130 922950..923180 + 231 WP_083087165.1 hypothetical protein Antitoxin
G6N15_RS04135 923240..923635 + 396 WP_083087164.1 PIN domain-containing protein Toxin
G6N15_RS04145 923997..925439 - 1443 WP_083087244.1 amidase -
G6N15_RS04150 925527..926243 - 717 WP_083087163.1 GAF and ANTAR domain-containing protein -
G6N15_RS04155 926429..926860 - 432 WP_083087162.1 hypothetical protein -
G6N15_RS04160 926981..927424 + 444 WP_083087161.1 cupin domain-containing protein -
G6N15_RS04165 927433..928206 - 774 WP_083087160.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(5-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14156.06 Da        Isoelectric Point: 6.3986

>T36243 WP_083087164.1 NZ_AP022583:923240-923635 [Mycobacterium noviomagense]
VSPHLLDASVLIALTVAEHEHHQRVSRWAAGIDSFAVCPITEGALIRFLVRIGESAAAAADLVRAVHRRPGVEFWPDSIS
YSDAHLTHVTGHRQVTDAYLASLAEANQGLLATLDEPLAKHFPNATVLIPQ

Download         Length: 396 bp

>T36243 NZ_AP022583:923240-923635 [Mycobacterium noviomagense]
GTGAGTCCACATCTGCTCGACGCCAGCGTGCTGATCGCGCTCACGGTCGCCGAGCACGAACATCACCAGCGGGTGTCGCG
ATGGGCGGCAGGCATCGATAGCTTCGCCGTCTGCCCCATCACCGAGGGTGCGCTGATTCGCTTCCTGGTCAGGATCGGTG
AGAGCGCCGCCGCGGCTGCCGATCTGGTACGCGCCGTCCACCGTCGGCCAGGCGTCGAGTTCTGGCCTGACTCAATCTCC
TACAGCGACGCCCACCTCACCCACGTGACGGGCCACCGCCAGGTTACGGACGCCTACCTGGCGAGCTTGGCCGAGGCCAA
CCAGGGACTGCTCGCCACCCTGGACGAGCCGCTGGCAAAACATTTCCCTAATGCGACTGTGTTGATCCCCCAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8050.19 Da        Isoelectric Point: 10.4526

>AT36243 WP_083087165.1 NZ_AP022583:922950-923180 [Mycobacterium noviomagense]
MRTTVDLPPAVHKRAAQLAKARGQSLSATVAELAARGLSQLDQPLRISIDKRSGFPVVSVGRRITAEDVAGALDDE

Download         Length: 231 bp

>AT36243 NZ_AP022583:922950-923180 [Mycobacterium noviomagense]
ATGCGGACCACTGTCGACCTCCCTCCAGCCGTGCACAAACGTGCCGCCCAGCTCGCCAAGGCGCGAGGCCAGTCGCTGTC
CGCGACAGTGGCGGAGCTGGCCGCGCGGGGGCTAAGCCAACTCGACCAACCGCTGCGCATCTCGATCGACAAGCGCTCCG
GTTTCCCGGTGGTAAGCGTCGGCCGGCGGATCACTGCCGAGGATGTCGCCGGCGCGCTGGACGATGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References