Detailed information of TA system TA036242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 4040781..4041321
• Replicon: chromosome
• Accession: NZ_AP022582
• Organism: Mycobacterium seoulense strain JCM 16018

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: G6N37_RS18740
• Protein ID: WP_163682673.1
• Coordinates: 4041013..4041321 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: G6N37_RS18735
• Protein ID: WP_163685218.1
• Coordinates: 4040781..4041026 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N37_RS18715	4036932..4037033	+	102	Protein_3693	putative zinc-binding metallopeptidase	-
G6N37_RS18720	4037128..4037472	-	345	WP_163682668.1	hypothetical protein	-
G6N37_RS18725	4037649..4038260	-	612	WP_163682670.1	hypothetical protein	-
G6N37_RS18730	4038456..4039262	-	807	WP_163682671.1	GAF and ANTAR domain-containing protein	-
G6N37_RS18735	4040781..4041026	+	246	WP_163685218.1	ribbon-helix-helix domain-containing protein	Antitoxin
G6N37_RS18740	4041013..4041321	+	309	WP_163682673.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
G6N37_RS18745	4041469..4041903	-	435	WP_163685220.1	septation ring formation regulator EzrA	-
G6N37_RS18750	4042825..4043541	-	717	WP_163682675.1	transposase	-
G6N37_RS18755	4043648..4044490	+	843	WP_163682677.1	helix-turn-helix domain-containing protein	-
G6N37_RS18760	4044457..4044678	+	222	WP_163682679.1	helix-turn-helix domain-containing protein	-
G6N37_RS18765	4044846..4045091	+	246	WP_197745709.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4031285..4051222	19937

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-98)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11157.96 Da
• Isoelectric Point: 11.9882

>T36242 WP_163682673.1 NZ_AP022582:4041013-4041321 [Mycobacterium seoulense]
MRRGELWFAATPGGDRPVLILTRDPVADRIGAVVVAALTRTRRGLVSELALTAAEDRVPSDCVVNFDNIHTLPRAALRRR
ITRLSTARVHQACRTLRAATGC

Nucleotide

• Length: 309 bp

>T36242 NZ_AP022582:4041013-4041321 [Mycobacterium seoulense]
ATGCGGCGCGGTGAACTGTGGTTCGCCGCGACACCCGGCGGCGACCGGCCCGTGCTCATTCTCACGCGAGATCCGGTTGC
CGACCGGATCGGCGCGGTCGTCGTGGCCGCATTGACGCGCACCCGTAGGGGACTGGTGTCGGAGTTGGCACTGACCGCCG
CCGAGGACCGCGTGCCAAGCGATTGCGTCGTCAATTTCGACAACATTCATACGTTGCCGCGCGCCGCGTTGCGACGCCGG
ATTACTCGTTTGTCTACGGCACGGGTGCACCAGGCGTGTCGGACACTTCGAGCAGCCACCGGCTGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9309.19 Da
• Isoelectric Point: 4.1765

>AT36242 WP_163685218.1 NZ_AP022582:4040781-4041026 [Mycobacterium seoulense]
MFSFRVDDEDAAAVEQWARRLHIDRSELLREALRRHLAELTADQDVQAYAEQPVTDDEKALAKIADWGPAEDWADWADAA
R

Nucleotide

• Length: 246 bp

>AT36242 NZ_AP022582:4040781-4041026 [Mycobacterium seoulense]
ATGTTCAGCTTTCGCGTCGATGACGAGGACGCGGCCGCGGTGGAACAGTGGGCGCGTCGGTTGCATATCGACCGGTCTGA
GCTTCTTCGCGAGGCACTACGACGCCACCTGGCCGAGCTCACGGCAGATCAAGACGTGCAAGCGTATGCCGAGCAGCCCG
TGACGGATGATGAGAAGGCCCTCGCCAAGATCGCCGATTGGGGGCCTGCCGAGGACTGGGCTGACTGGGCCGATGCGGCG
CGGTGA