Detailed information of TA system TA036241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3338013..3338679
• Replicon: chromosome
• Accession: NZ_AP022582
• Organism: Mycobacterium seoulense strain JCM 16018

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: A0A1A2X2L5
• Locus tag: G6N37_RS15260
• Protein ID: WP_067926058.1
• Coordinates: 3338013..3338486 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: -
• Locus tag: G6N37_RS15265
• Protein ID: WP_163681539.1
• Coordinates: 3338491..3338679 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N37_RS15240	3334271..3335509	+	1239	WP_102419640.1	acetyl-CoA acetyltransferase	-
G6N37_RS15245	3335499..3337026	+	1528	Protein_3014	carotenoid oxygenase family protein	-
G6N37_RS15250	3337026..3337508	+	483	WP_067926053.1	VOC family protein	-
G6N37_RS15255	3337514..3337948	-	435	WP_102419638.1	hypothetical protein	-
G6N37_RS15260	3338013..3338486	-	474	WP_067926058.1	SRPBCC family protein	Toxin
G6N37_RS15265	3338491..3338679	-	189	WP_163681539.1	antitoxin	Antitoxin
G6N37_RS15270	3338748..3341120	-	2373	WP_163681541.1	cation-translocating P-type ATPase	-
G6N37_RS15275	3341117..3342703	-	1587	WP_163681543.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 16994.57 Da
• Isoelectric Point: 8.5212

>T36241 WP_067926058.1 NZ_AP022582:c3338486-3338013 [Mycobacterium seoulense]
MAKLSGSIDVPLPPEVAWKHASDLSRYKDWLTIHRVWRSTLPDDIDKGTVVESIVEVKGMYNRIRWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPAEEGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDTSLQNFVTVFTRPDPGMNGSGGGHR

Nucleotide

• Length: 474 bp

>T36241 NZ_AP022582:c3338486-3338013 [Mycobacterium seoulense]
ATGGCGAAACTCTCCGGATCCATCGACGTCCCGCTGCCACCCGAGGTGGCCTGGAAGCATGCCTCCGACCTGTCCCGGTA
CAAGGACTGGCTGACCATCCACCGGGTGTGGCGCAGCACACTGCCCGACGACATCGACAAGGGCACGGTCGTGGAGTCGA
TCGTCGAAGTCAAGGGCATGTACAACCGGATCAGGTGGACGGTCGTTCGGTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGTGGCGTCAAGGTCAAACTCATGGCCAAAGTTCAGCCCGCCGAGGAGGGCTCCGTCGTCAGCTTCGA
CGTCCACCTCGGTGGCCCGGCACTGTTCGGGCCGATCGGCATGATCGTCGCCGCCGCGCTGCGCGGCGACATCGACACGT
CGCTGCAGAACTTCGTCACGGTGTTCACTCGGCCCGACCCCGGCATGAACGGTTCCGGCGGCGGCCACCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6779.42 Da
• Isoelectric Point: 4.7335

>AT36241 WP_163681539.1 NZ_AP022582:c3338679-3338491 [Mycobacterium seoulense]
MGFLDKAKELLSQNADKVETAIDKAGEFVDDKTQGKYSDTIHKVQEQAKKAAESAAQGDHQD

Nucleotide

• Length: 189 bp

>AT36241 NZ_AP022582:c3338679-3338491 [Mycobacterium seoulense]
ATGGGATTCCTGGACAAGGCCAAAGAACTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCGATCGACAAGGCCGGCGA
ATTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATCCACAAAGTGCAGGAACAGGCCAAGAAGGCGGCCGAAT
CGGCGGCACAAGGCGACCACCAGGACTGA

Structures

Toxin

• AlphaFold DB: A0A1A2X2L5