Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 5074370..5075055 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS23535 Protein ID WP_085162418.1
Coordinates 5074370..5074801 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS23540 Protein ID WP_085162417.1
Coordinates 5074798..5075055 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS23500 5069388..5069777 + 390 WP_085162341.1 MaoC family dehydratase -
G6N24_RS23505 5069777..5070961 + 1185 WP_085162340.1 lipid-transfer protein -
G6N24_RS23510 5071152..5071409 + 258 WP_085162339.1 hypothetical protein -
G6N24_RS23520 5071566..5073119 + 1554 Protein_4619 IS21 family transposase -
G6N24_RS23525 5073192..5073947 + 756 WP_163745618.1 IS21-like element helper ATPase IstB -
G6N24_RS23530 5074043..5074177 + 135 Protein_4621 toxin-antitoxin system HicB family antitoxin -
G6N24_RS23535 5074370..5074801 - 432 WP_085162418.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS23540 5074798..5075055 - 258 WP_085162417.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N24_RS23545 5075168..5076028 - 861 WP_085162416.1 MaoC family dehydratase N-terminal domain-containing protein -
G6N24_RS23550 5076030..5077724 - 1695 WP_085162422.1 3-oxosteroid 1-dehydrogenase -
G6N24_RS23555 5077796..5078581 + 786 WP_085162415.1 2-keto-4-pentenoate hydratase -
G6N24_RS23560 5078597..5078785 - 189 Protein_4627 hypothetical protein -
G6N24_RS23565 5078760..5079674 + 915 WP_085162413.1 acetaldehyde dehydrogenase (acetylating) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-37)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15697.86 Da        Isoelectric Point: 4.8884

>T36240 WP_085162418.1 NZ_AP022581:c5074801-5074370 [Mycobacterium lacus]
MRLLDLNILIYAIDESSPRHEPARAWLDDTLSGSGTVAFAWHVLVGFVRLSTRAAVFERPLKVDEAFDVVDGWLAQPCVT
VVHPTDRHTVVLRELLTPLGAAGNLTSDAHLAALSVEHGAELCSTDVDFSRFSGVRWIDPLQP

Download         Length: 432 bp

>T36240 NZ_AP022581:c5074801-5074370 [Mycobacterium lacus]
ATGAGACTGCTCGATCTCAACATCCTTATTTACGCGATCGACGAGTCGTCACCTCGCCATGAGCCGGCTCGCGCTTGGCT
TGACGACACCTTGTCGGGCTCGGGCACAGTCGCTTTCGCATGGCACGTCCTCGTCGGCTTCGTCCGCCTGTCGACGCGCG
CCGCGGTATTTGAGCGGCCTTTGAAGGTCGACGAGGCCTTCGACGTCGTTGATGGATGGTTGGCGCAACCCTGCGTTACG
GTCGTTCATCCGACGGATCGCCACACGGTCGTCCTTCGCGAATTGCTGACTCCGCTTGGCGCGGCGGGAAATCTCACCAG
CGACGCCCATCTGGCGGCCCTGTCTGTCGAACACGGCGCCGAACTGTGCTCCACCGATGTCGATTTCAGTCGATTTTCCG
GCGTGCGCTGGATCGATCCGCTACAGCCGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9409.81 Da        Isoelectric Point: 11.3519

>AT36240 WP_085162417.1 NZ_AP022581:c5075055-5074798 [Mycobacterium lacus]
MRTTVTLDPDVVAALQRAARERGTSFKAVLNDAVRRGLGGEPSRRRYRTPSRDMGLRAGFDIDKALTLVAADEDAEVLRK
LALRK

Download         Length: 258 bp

>AT36240 NZ_AP022581:c5075055-5074798 [Mycobacterium lacus]
ATGCGTACCACCGTGACGCTGGATCCCGATGTTGTCGCGGCCCTGCAGCGCGCAGCCCGCGAGCGGGGAACCTCTTTCAA
AGCGGTCCTGAACGACGCGGTGCGGCGCGGATTGGGCGGCGAGCCCTCCCGGCGGCGCTATCGCACGCCAAGTCGCGACA
TGGGACTGCGAGCGGGATTCGACATCGACAAGGCGTTGACGCTGGTTGCGGCGGACGAGGACGCAGAGGTCTTACGTAAG
CTTGCGCTCCGCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References