Detailed information of TA system TA036239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4841264..4841927
• Replicon: chromosome
• Accession: NZ_AP022581
• Organism: Mycobacterium lacus strain JCM 15657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N24_RS22365
• Protein ID: WP_085158890.1
• Coordinates: 4841264..4841692 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N24_RS22370
• Protein ID: WP_085158892.1
• Coordinates: 4841679..4841927 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N24_RS22345	4837214..4838272	-	1059	WP_085158882.1	dihydrodipicolinate reductase	-
G6N24_RS22350	4838364..4839503	-	1140	WP_085158884.1	hypothetical protein	-
G6N24_RS22355	4839500..4840819	-	1320	WP_085158886.1	hypothetical protein	-
G6N24_RS22360	4840903..4841241	+	339	WP_085158888.1	hypothetical protein	-
G6N24_RS22365	4841264..4841692	-	429	WP_085158890.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N24_RS22370	4841679..4841927	-	249	WP_085158892.1	hypothetical protein	Antitoxin
G6N24_RS22375	4841978..4843327	-	1350	WP_085158894.1	CHAT domain-containing protein	-
G6N24_RS22380	4843324..4845015	-	1692	WP_085158896.1	hypothetical protein	-
G6N24_RS22385	4845104..4845574	-	471	WP_085158898.1	lipoprotein LpqH	-
G6N24_RS22390	4845915..4846676	-	762	WP_085158901.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-132)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15748.01 Da
• Isoelectric Point: 7.3501

>T36239 WP_085158890.1 NZ_AP022581:c4841692-4841264 [Mycobacterium lacus]
MLCPDVNVLLYAYRRDSIAHSAYVDWLQQTMTGHEPVGVSELVLSAVVRLATNHRIYRQPSGTADALEFCQAIRSAPAAV
PLRPGVKHWEIFAQLCRDVAATANLVPDAYHAALAIENGATWITTDRSYARFPILQWRGPFG

Nucleotide

• Length: 429 bp

>T36239 NZ_AP022581:c4841692-4841264 [Mycobacterium lacus]
ATGCTGTGCCCTGACGTCAACGTTCTGCTCTACGCCTATCGCCGTGACAGCATCGCGCACTCCGCGTACGTTGACTGGCT
GCAACAAACGATGACAGGGCATGAGCCCGTGGGAGTAAGTGAGCTGGTGCTTTCCGCAGTTGTCCGGCTGGCGACCAACC
ACCGGATCTATCGGCAGCCCAGCGGCACCGCAGACGCGCTCGAGTTCTGCCAGGCGATCCGGTCCGCCCCGGCCGCGGTC
CCACTGCGGCCGGGTGTCAAGCATTGGGAGATCTTTGCCCAGTTGTGCCGCGATGTCGCGGCCACCGCAAACCTGGTCCC
CGATGCCTACCACGCGGCGCTGGCAATCGAAAACGGAGCTACCTGGATCACCACTGACCGCAGCTACGCCAGGTTCCCGA
TTCTGCAGTGGCGCGGCCCGTTTGGGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8687.91 Da
• Isoelectric Point: 6.2816

>AT36239 WP_085158892.1 NZ_AP022581:c4841927-4841679 [Mycobacterium lacus]
VRTTVNLSDDLLAEAKVLAAKSRRPLGSVIDDALRLLLRREQAKAPQKAWSFPTGGAGGLQPGVNLEDREALADLLGDNA
VP

Nucleotide

• Length: 249 bp

>AT36239 NZ_AP022581:c4841927-4841679 [Mycobacterium lacus]
GTGCGTACAACCGTGAACCTGTCCGACGACCTGCTTGCCGAGGCGAAAGTGCTGGCGGCGAAATCACGGCGCCCGCTCGG
TTCGGTGATCGACGACGCATTGCGGCTGTTGCTCAGGCGCGAGCAGGCGAAGGCGCCGCAAAAGGCTTGGTCGTTTCCCA
CTGGAGGCGCCGGCGGCCTGCAGCCCGGGGTGAACCTCGAGGATCGGGAAGCGTTGGCGGACTTGCTGGGTGACAATGCT
GTGCCCTGA