Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 4660088..4660614 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag G6N24_RS21490 Protein ID WP_085162686.1
Coordinates 4660088..4660390 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag G6N24_RS21495 Protein ID WP_085162687.1
Coordinates 4660387..4660614 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS21470 4656097..4657563 + 1467 WP_085162685.1 glutamate synthase subunit beta -
G6N24_RS21475 4658040..4658126 - 87 Protein_4221 LLM class F420-dependent oxidoreductase -
G6N24_RS21480 4658270..4659277 + 1008 WP_085162736.1 PHP domain-containing protein -
G6N24_RS21485 4659500..4660044 - 545 Protein_4223 hypothetical protein -
G6N24_RS21490 4660088..4660390 - 303 WP_085162686.1 toxin Toxin
G6N24_RS21495 4660387..4660614 - 228 WP_085162687.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N24_RS21500 4660681..4661328 - 648 WP_085162737.1 TetR/AcrR family transcriptional regulator -
G6N24_RS21505 4661405..4662874 + 1470 WP_085162688.1 NAD(P)/FAD-dependent oxidoreductase -
G6N24_RS21510 4662871..4663359 - 489 WP_085162689.1 ribonuclease E activity regulator RraA -
G6N24_RS21515 4663376..4663801 - 426 WP_085162690.1 nucleoid-structuring protein H-NS -
G6N24_RS21520 4663943..4664599 - 657 WP_085162691.1 hypothetical protein -
G6N24_RS21525 4664730..4665128 - 399 WP_085162739.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10481.17 Da        Isoelectric Point: 4.1087

>T36238 WP_085162686.1 NZ_AP022581:c4660390-4660088 [Mycobacterium lacus]
VIAPGAIAPRRDTDGQLYVAVLSNAIHLAADTGRLITCPFVPGQIPDEVMAMVVTVDQPPGALLPELVQWLPRSALDEPI
GTIGETALRETASIVTALIT

Download         Length: 303 bp

>T36238 NZ_AP022581:c4660390-4660088 [Mycobacterium lacus]
GTGATCGCTCCGGGCGCCATCGCACCCCGCCGCGACACCGACGGTCAGCTGTATGTTGCGGTGCTGTCCAACGCAATCCA
TCTCGCGGCCGACACTGGACGGCTGATCACCTGCCCGTTCGTTCCGGGCCAGATTCCAGACGAGGTCATGGCGATGGTCG
TCACCGTCGATCAGCCCCCAGGCGCGCTCTTGCCCGAGCTGGTGCAATGGCTGCCACGTTCCGCCCTCGACGAGCCGATC
GGCACCATCGGAGAGACCGCCCTGCGTGAAACCGCGTCAATCGTGACTGCGCTCATCACGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8195.27 Da        Isoelectric Point: 9.6568

>AT36238 WP_085162687.1 NZ_AP022581:c4660614-4660387 [Mycobacterium lacus]
VAKEKISVTVDAAVLAAADADAQAAGLNRSEMIERALRNEHLRVALRNYKSRTIPALRIDAYADQVYQANRAGGW

Download         Length: 228 bp

>AT36238 NZ_AP022581:c4660614-4660387 [Mycobacterium lacus]
GTGGCGAAAGAGAAGATTTCGGTGACGGTCGACGCGGCCGTGCTCGCGGCGGCCGACGCGGATGCCCAGGCCGCGGGCCT
GAATCGGTCGGAGATGATCGAACGGGCGCTCCGGAACGAGCATCTACGCGTTGCGCTGCGCAACTACAAGAGTCGAACAA
TTCCGGCGTTGCGGATCGATGCCTACGCCGACCAGGTCTACCAGGCAAATCGGGCTGGTGGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References