Detailed information of TA system TA036237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4247088..4247635
• Replicon: chromosome
• Accession: NZ_AP022581
• Organism: Mycobacterium lacus strain JCM 15657

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6N24_RS19590
• Protein ID: WP_085159544.1
• Coordinates: 4247088..4247369 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G6N24_RS19595
• Protein ID: WP_085159546.1
• Coordinates: 4247366..4247635 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N24_RS19560	4242690..4243871	-	1182	WP_085159871.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
G6N24_RS19565	4243868..4244581	-	714	WP_085159869.1	SDR family NAD(P)-dependent oxidoreductase	-
G6N24_RS19570	4244647..4245078	+	432	WP_163745570.1	redox-sensitive transcriptional activator SoxR	-
G6N24_RS19575	4245334..4245669	-	336	WP_163745571.1	hypothetical protein	-
G6N24_RS19580	4245792..4246382	+	591	WP_163745572.1	hypothetical protein	-
G6N24_RS19585	4246387..4246701	+	315	WP_163745573.1	hypothetical protein	-
G6N24_RS19590	4247088..4247369	-	282	WP_085159544.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N24_RS19595	4247366..4247635	-	270	WP_085159546.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N24_RS19600	4248142..4249450	-	1309	Protein_3857	ISL3 family transposase	-
G6N24_RS19605	4249592..4251412	-	1821	WP_085162742.1	phosphoenolpyruvate carboxykinase (GTP)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4248142..4248633	491

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10770.42 Da
• Isoelectric Point: 10.9301

>T36237 WP_085159544.1 NZ_AP022581:c4247369-4247088 [Mycobacterium lacus]
MTGQDAPWSVQLSPTAVRALDRLPHKIAAAIVEFVTGTLPTGPYRLAKPLRFELEGWRVARRGDYRITFRALEDDRVLYV
GRIEHRAHIYRRQ

Nucleotide

• Length: 282 bp

>T36237 NZ_AP022581:c4247369-4247088 [Mycobacterium lacus]
TTGACGGGCCAGGATGCGCCGTGGTCTGTCCAGCTGTCACCGACCGCCGTGCGGGCGCTCGATCGTCTGCCGCACAAGAT
CGCCGCGGCCATCGTTGAATTCGTCACTGGCACCTTGCCGACCGGCCCGTACCGGCTAGCCAAGCCGCTGCGATTCGAGT
TGGAAGGATGGCGCGTGGCGCGCCGCGGCGATTACCGAATCACGTTCCGCGCACTCGAGGACGACCGCGTCCTCTACGTC
GGCCGCATTGAGCACCGTGCCCACATCTATCGACGCCAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9658.84 Da
• Isoelectric Point: 4.6239

>AT36237 WP_085159546.1 NZ_AP022581:c4247635-4247366 [Mycobacterium lacus]
MKTVPLTEAKDKLSALVDEADTTHEIIQITRHGRVAAVIMSADDLESLNETLHALRTPGIAEELAQADADYAVGNTVSGE
QIRKRYGLN

Nucleotide

• Length: 270 bp

>AT36237 NZ_AP022581:c4247635-4247366 [Mycobacterium lacus]
ATGAAGACGGTACCGCTGACAGAGGCTAAAGACAAGCTTTCCGCTTTGGTCGACGAGGCCGACACCACCCACGAAATCAT
TCAGATCACCCGGCACGGCCGCGTTGCCGCGGTCATCATGTCCGCCGACGATCTCGAGTCCCTCAATGAGACCCTGCATG
CGCTGCGGACCCCAGGTATCGCCGAGGAACTCGCGCAGGCCGACGCCGACTATGCCGTCGGAAACACCGTGAGCGGCGAA
CAGATCCGCAAACGGTACGGCCTGAATTGA