Detailed information of TA system TA036235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3567503..3568170
• Replicon: chromosome
• Accession: NZ_AP022581
• Organism: Mycobacterium lacus strain JCM 15657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N24_RS16330
• Protein ID: WP_085160788.1
• Coordinates: 3567778..3568170 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N24_RS16325
• Protein ID: WP_085160790.1
• Coordinates: 3567503..3567778 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N24_RS16310	3563811..3564986	+	1176	WP_085162091.1	trehalose-phosphatase	-
G6N24_RS16320	3565062..3567395	+	2334	Protein_3212	PE family protein	-
G6N24_RS16325	3567503..3567778	+	276	WP_085160790.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N24_RS16330	3567778..3568170	+	393	WP_085160788.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N24_RS16335	3568241..3569104	-	864	WP_085160786.1	MaoC family dehydratase	-
G6N24_RS16340	3569201..3569905	+	705	WP_085160784.1	phosphoglycerate mutase family protein	-
G6N24_RS16345	3569958..3571901	+	1944	WP_085160782.1	SDR family oxidoreductase	-
G6N24_RS16350	3571902..3572765	-	864	WP_085160780.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-61)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14399.83 Da
• Isoelectric Point: 10.1536

>T36235 WP_085160788.1 NZ_AP022581:3567778-3568170 [Mycobacterium lacus]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRRPRVSSALARTEVMRALLHQGEPARKAGRRVLANLDLLRVDNRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDERMRDAAEALGLVVIAPC

Nucleotide

• Length: 393 bp

>T36235 NZ_AP022581:3567778-3568170 [Mycobacterium lacus]
ATGGCGGCCATCTACCTCGACTCGTCGGCCATCGTCAAGCTTGCGGTTCGTGAGCCGGAGTCGGACGCGCTGCGTCGCTA
CCTGCGCACCCGCCGTCCGCGGGTGTCGAGTGCCCTGGCGCGCACGGAGGTCATGCGGGCTTTGCTCCACCAGGGCGAAC
CAGCCCGCAAGGCCGGACGCCGGGTGCTGGCCAACCTAGACCTGCTTCGCGTCGACAACCGGGTGCTCGATCTCGCTGGT
GGACTGCTGCCATTCGAACTACGCACGCTCGACGCAATTCACCTTGCGACGGCCCAGCGGCTCGGCGTCGACCTGGGCCG
GTTGTGCACCTACGACGAGCGGATGCGCGACGCCGCCGAGGCGCTCGGCCTGGTCGTGATTGCCCCTTGTTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10110.50 Da
• Isoelectric Point: 4.4766

>AT36235 WP_085160790.1 NZ_AP022581:3567503-3567778 [Mycobacterium lacus]
MPSVGVRELRQRASELLRRVEAGETIEITDRGRPVALLSPLPEGGPYQRMLASGEIERATLDLDDLPEPLDLEAGVELPS
VTLARLREHER

Nucleotide

• Length: 276 bp

>AT36235 NZ_AP022581:3567503-3567778 [Mycobacterium lacus]
ATGCCTTCGGTGGGTGTGCGTGAGCTGCGGCAGCGCGCCAGCGAACTGCTTCGCCGCGTCGAGGCTGGCGAGACGATCGA
GATCACCGACCGCGGTCGGCCCGTCGCCCTGCTCTCGCCGTTGCCGGAGGGCGGTCCCTACCAGCGGATGCTGGCAAGCG
GCGAGATCGAACGTGCGACGCTCGATCTCGATGATCTGCCCGAACCGCTTGACCTCGAAGCGGGCGTCGAGCTGCCGTCG
GTGACGCTCGCGCGCCTGCGCGAGCACGAGCGTTGA