Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2676461..2677100 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS12250 Protein ID WP_085162928.1
Coordinates 2676678..2677100 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS12245 Protein ID WP_085162927.1
Coordinates 2676461..2676694 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS12215 2671582..2673108 + 1527 WP_085162921.1 PecA family PE domain-processing aspartic protease -
G6N24_RS12220 2673119..2673949 - 831 WP_085162922.1 DegV family protein -
G6N24_RS12225 2673949..2674692 - 744 WP_085162923.1 SGNH/GDSL hydrolase family protein -
G6N24_RS12230 2674682..2675368 - 687 WP_085162924.1 histidine phosphatase family protein -
G6N24_RS12235 2675365..2675754 - 390 WP_085162925.1 ribosome silencing factor -
G6N24_RS12240 2675751..2676416 - 666 WP_085162926.1 nicotinate-nucleotide adenylyltransferase -
G6N24_RS12245 2676461..2676694 + 234 WP_085162927.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G6N24_RS12250 2676678..2677100 + 423 WP_085162928.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS12255 2677147..2678193 + 1047 WP_085162929.1 class I SAM-dependent methyltransferase -
G6N24_RS12260 2678269..2679708 - 1440 WP_085162930.1 VWA domain-containing protein -
G6N24_RS12265 2679708..2680583 - 876 WP_085162931.1 MoxR family ATPase -
G6N24_RS12270 2680610..2681857 - 1248 WP_085162932.1 glutamate-5-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-129)

Antitoxin

SpoVT-AbrB domain

(2-33)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14803.96 Da        Isoelectric Point: 7.4706

>T36234 WP_085162928.1 NZ_AP022581:2676678-2677100 [Mycobacterium lacus]
MPASGSTVLVDTSVAVALVVADHDHHEDTFQALRGRTLGLAGHAAFETFSVLTRLPPPARRTPATVAKLLTRTFPETRFL
GPRAATSLLTGLGAAEIAGGAVYDALVGAVANEHRLPLATRDRRALEVYRALEVNVELLA

Download         Length: 423 bp

>T36234 NZ_AP022581:2676678-2677100 [Mycobacterium lacus]
ATGCCGGCCAGCGGTAGCACCGTGCTCGTAGACACGAGCGTCGCCGTCGCACTGGTGGTCGCCGATCACGACCACCACGA
AGACACCTTCCAAGCGCTACGCGGTCGGACGCTCGGTCTTGCCGGCCACGCCGCGTTCGAAACCTTCTCCGTTCTCACCC
GCTTGCCGCCGCCGGCCCGCAGGACACCGGCGACCGTCGCCAAGCTGCTGACGCGCACCTTCCCAGAGACCAGATTCCTC
GGCCCACGGGCGGCAACGTCGCTGCTGACCGGACTCGGAGCCGCCGAAATCGCCGGTGGGGCGGTGTACGACGCGCTGGT
CGGTGCGGTCGCAAACGAGCATCGACTACCCCTGGCAACTCGCGATCGGCGGGCGCTGGAGGTCTATCGCGCGCTGGAGG
TGAACGTCGAGCTGCTGGCCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8193.34 Da        Isoelectric Point: 5.1037

>AT36234 WP_085162927.1 NZ_AP022581:2676461-2676694 [Mycobacterium lacus]
MRATIDKAGRLVIPKPLRDHLGLRPGEVEVTADGAALRVEPLAGESLDERDGRLVIPAGGAEIDDAVVRTLRDAGQR

Download         Length: 234 bp

>AT36234 NZ_AP022581:2676461-2676694 [Mycobacterium lacus]
ATGCGTGCAACCATTGATAAGGCAGGCAGATTGGTTATTCCTAAGCCATTGCGAGATCATCTCGGGCTCAGGCCGGGTGA
AGTCGAGGTGACCGCCGACGGGGCAGCCCTGCGCGTCGAGCCCCTCGCCGGTGAGTCGCTCGATGAGCGGGACGGCCGCT
TAGTGATACCCGCCGGCGGCGCGGAGATTGACGACGCGGTCGTGCGGACGCTGCGCGATGCCGGCCAGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References