Detailed information of TA system TA036234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2676461..2677100
• Replicon: chromosome
• Accession: NZ_AP022581
• Organism: Mycobacterium lacus strain JCM 15657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N24_RS12250
• Protein ID: WP_085162928.1
• Coordinates: 2676678..2677100 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N24_RS12245
• Protein ID: WP_085162927.1
• Coordinates: 2676461..2676694 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N24_RS12215	2671582..2673108	+	1527	WP_085162921.1	PecA family PE domain-processing aspartic protease	-
G6N24_RS12220	2673119..2673949	-	831	WP_085162922.1	DegV family protein	-
G6N24_RS12225	2673949..2674692	-	744	WP_085162923.1	SGNH/GDSL hydrolase family protein	-
G6N24_RS12230	2674682..2675368	-	687	WP_085162924.1	histidine phosphatase family protein	-
G6N24_RS12235	2675365..2675754	-	390	WP_085162925.1	ribosome silencing factor	-
G6N24_RS12240	2675751..2676416	-	666	WP_085162926.1	nicotinate-nucleotide adenylyltransferase	-
G6N24_RS12245	2676461..2676694	+	234	WP_085162927.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
G6N24_RS12250	2676678..2677100	+	423	WP_085162928.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N24_RS12255	2677147..2678193	+	1047	WP_085162929.1	class I SAM-dependent methyltransferase	-
G6N24_RS12260	2678269..2679708	-	1440	WP_085162930.1	VWA domain-containing protein	-
G6N24_RS12265	2679708..2680583	-	876	WP_085162931.1	MoxR family ATPase	-
G6N24_RS12270	2680610..2681857	-	1248	WP_085162932.1	glutamate-5-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-129)

Antitoxin

• SpoVT-AbrB domain (2-33)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14803.96 Da
• Isoelectric Point: 7.4706

>T36234 WP_085162928.1 NZ_AP022581:2676678-2677100 [Mycobacterium lacus]
MPASGSTVLVDTSVAVALVVADHDHHEDTFQALRGRTLGLAGHAAFETFSVLTRLPPPARRTPATVAKLLTRTFPETRFL
GPRAATSLLTGLGAAEIAGGAVYDALVGAVANEHRLPLATRDRRALEVYRALEVNVELLA

Nucleotide

• Length: 423 bp

>T36234 NZ_AP022581:2676678-2677100 [Mycobacterium lacus]
ATGCCGGCCAGCGGTAGCACCGTGCTCGTAGACACGAGCGTCGCCGTCGCACTGGTGGTCGCCGATCACGACCACCACGA
AGACACCTTCCAAGCGCTACGCGGTCGGACGCTCGGTCTTGCCGGCCACGCCGCGTTCGAAACCTTCTCCGTTCTCACCC
GCTTGCCGCCGCCGGCCCGCAGGACACCGGCGACCGTCGCCAAGCTGCTGACGCGCACCTTCCCAGAGACCAGATTCCTC
GGCCCACGGGCGGCAACGTCGCTGCTGACCGGACTCGGAGCCGCCGAAATCGCCGGTGGGGCGGTGTACGACGCGCTGGT
CGGTGCGGTCGCAAACGAGCATCGACTACCCCTGGCAACTCGCGATCGGCGGGCGCTGGAGGTCTATCGCGCGCTGGAGG
TGAACGTCGAGCTGCTGGCCTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8193.34 Da
• Isoelectric Point: 5.1037

>AT36234 WP_085162927.1 NZ_AP022581:2676461-2676694 [Mycobacterium lacus]
MRATIDKAGRLVIPKPLRDHLGLRPGEVEVTADGAALRVEPLAGESLDERDGRLVIPAGGAEIDDAVVRTLRDAGQR

Nucleotide

• Length: 234 bp

>AT36234 NZ_AP022581:2676461-2676694 [Mycobacterium lacus]
ATGCGTGCAACCATTGATAAGGCAGGCAGATTGGTTATTCCTAAGCCATTGCGAGATCATCTCGGGCTCAGGCCGGGTGA
AGTCGAGGTGACCGCCGACGGGGCAGCCCTGCGCGTCGAGCCCCTCGCCGGTGAGTCGCTCGATGAGCGGGACGGCCGCT
TAGTGATACCCGCCGGCGGCGCGGAGATTGACGACGCGGTCGTGCGGACGCTGCGCGATGCCGGCCAGCGGTAG