Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2233586..2234281 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS10165 Protein ID WP_085161622.1
Coordinates 2233586..2234020 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS10170 Protein ID WP_085161621.1
Coordinates 2234027..2234281 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS10145 2228879..2229865 - 987 WP_085159047.1 YafY family transcriptional regulator -
G6N24_RS10150 2229873..2231231 - 1359 WP_139822307.1 Pup--protein ligase -
G6N24_RS10155 2231281..2232792 - 1512 WP_163745483.1 PE family protein -
G6N24_RS10160 2232958..2233467 - 510 WP_085161623.1 nitroreductase family deazaflavin-dependent oxidoreductase -
G6N24_RS10165 2233586..2234020 - 435 WP_085161622.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS10170 2234027..2234281 - 255 WP_085161621.1 antitoxin Antitoxin
G6N24_RS10175 2234638..2235333 - 696 Protein_2016 proteasome subunit alpha -
G6N24_RS10180 2235330..2236202 - 873 WP_085161619.1 proteasome subunit beta -
G6N24_RS10185 2236199..2236393 - 195 WP_085161617.1 ubiquitin-like protein Pup -
G6N24_RS10190 2236497..2238005 - 1509 WP_163745484.1 pup deamidase/depupylase -
G6N24_RS10195 2238116..2238322 + 207 WP_085161613.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15602.84 Da        Isoelectric Point: 6.7586

>T36233 WP_085161622.1 NZ_AP022581:c2234020-2233586 [Mycobacterium lacus]
MKIVDANVLLYAVNTSSEHHTSSLRWLDGALSGADRVGFAWVPLLAFVRLVTKHGLFPRPMSPEDAIGQVADWLTAPSAV
LVNPTARHADLMARMLAQVGTGGNLVNDAHLAALAVEHRASIVSYDSDFGRFDGMRWDRPSALL

Download         Length: 435 bp

>T36233 NZ_AP022581:c2234020-2233586 [Mycobacterium lacus]
ATGAAGATCGTCGACGCGAATGTGCTGCTGTATGCGGTCAACACGTCCAGCGAACACCACACGTCGTCCTTACGCTGGCT
CGACGGCGCGCTATCGGGCGCCGACCGCGTCGGGTTCGCGTGGGTCCCATTGCTGGCATTCGTTCGGCTCGTGACCAAGC
ATGGTTTGTTCCCCCGCCCGATGTCTCCGGAGGACGCCATCGGTCAGGTCGCGGATTGGCTCACCGCGCCGAGCGCGGTG
CTGGTGAATCCGACCGCACGCCACGCCGACCTCATGGCGAGAATGCTGGCGCAGGTGGGAACCGGCGGCAACCTCGTGAA
CGACGCCCACTTGGCGGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCTTACGACAGCGATTTTGGCCGATTCGACG
GCATGCGCTGGGATCGTCCGTCGGCGCTGCTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9575.82 Da        Isoelectric Point: 10.6263

>AT36233 WP_085161621.1 NZ_AP022581:c2234281-2234027 [Mycobacterium lacus]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASRRPEPGRFVTRATDLGVPGVNLDRALQLAAELEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT36233 NZ_AP022581:c2234281-2234027 [Mycobacterium lacus]
ATGCGCACCACGGTGACGTTGGACGACGACGTCGAGCAGTTGGTGCGGCGCCGGATGGCCGAGCGGCAGGTGTCCTTCAA
GAAGGCGCTCAACGACGCGATTCGCGACGGTGCTTCCCGGCGACCCGAACCGGGGCGGTTTGTGACCCGCGCCACCGACC
TGGGCGTGCCCGGGGTCAATCTCGACCGGGCGTTGCAACTCGCCGCCGAGCTCGAGGACGAGGAACTTGTGCGTCGTCAG
CGGCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References