36231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1758899..1759548 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS08070 Protein ID WP_085158412.1
Coordinates 1759153..1759548 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS08065 Protein ID WP_085158410.1
Coordinates 1758899..1759153 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS08045 1755493..1755711 + 219 WP_139822264.1 hypothetical protein -
G6N24_RS08050 1755730..1756725 - 996 WP_085158404.1 retinol dehydrogenase -
G6N24_RS08055 1756869..1757750 + 882 WP_085158406.1 SDR family NAD(P)-dependent oxidoreductase -
G6N24_RS08060 1757928..1758854 + 927 WP_085158408.1 DMT family transporter -
G6N24_RS08065 1758899..1759153 + 255 WP_085158410.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N24_RS08070 1759153..1759548 + 396 WP_085158412.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS08075 1759587..1760789 - 1203 WP_085158414.1 cytochrome P450 -
G6N24_RS08080 1760914..1762389 - 1476 WP_085158416.1 NADH-quinone oxidoreductase subunit C -
G6N24_RS08085 1762386..1763855 - 1470 WP_085158418.1 hydrogenase -
G6N24_RS08090 1763855..1764517 - 663 WP_085158420.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14322.17 Da        Isoelectric Point: 5.1653

>T36231 WP_085158412.1 NZ_AP022581:1759153-1759548 [Mycobacterium lacus]
MVIDTSALVAMLNDEPDAGRFEAAVEADHVRLMSTASYLEAAIVIETRFGEPGGRELDLWLHRAAVDLVSVDSNQAETAR
VAYRTYGKGRHRAGLNYGDCFSYALAKVSGQPLLCKRDDFAHTDIHVVLAV

Download         Length: 396 bp

>T36231 NZ_AP022581:1759153-1759548 [Mycobacterium lacus]
ATGGTGATCGACACATCTGCGTTGGTCGCGATGCTCAACGATGAGCCTGACGCCGGGCGGTTCGAGGCAGCGGTGGAAGC
GGATCATGTTCGGCTGATGTCGACAGCGTCCTACCTGGAGGCGGCGATCGTGATCGAAACCCGCTTCGGTGAACCGGGGG
GACGGGAGCTAGATCTGTGGCTCCATCGCGCCGCAGTCGACCTTGTCAGCGTCGATTCCAACCAGGCGGAGACCGCACGA
GTCGCCTACCGCACCTACGGCAAGGGGCGGCATCGTGCCGGCCTGAACTATGGCGACTGTTTCTCCTACGCCCTGGCCAA
GGTCAGCGGCCAGCCGCTCCTGTGTAAACGTGACGACTTCGCACACACCGACATTCACGTGGTTCTCGCTGTCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9281.67 Da        Isoelectric Point: 6.3560

>AT36231 WP_085158410.1 NZ_AP022581:1758899-1759153 [Mycobacterium lacus]
MALSIKDPEADRLARELAARTGETLTEAVVVALRERLARETGRARSIPLREELAAIRRRCAALPVLDTRTADEVLGYDER
GLPV

Download         Length: 255 bp

>AT36231 NZ_AP022581:1758899-1759153 [Mycobacterium lacus]
ATGGCGTTGAGCATCAAAGATCCCGAGGCCGACCGCCTTGCCAGGGAACTGGCAGCGCGCACGGGTGAGACGTTGACCGA
AGCGGTGGTGGTCGCGTTGCGGGAACGGCTCGCCCGCGAGACCGGGCGCGCGAGGTCGATTCCGCTGCGCGAGGAGTTAG
CGGCCATCCGCCGCCGCTGCGCGGCCTTGCCGGTGCTCGACACTCGAACCGCGGATGAGGTCCTCGGCTACGACGAGCGA
GGTTTGCCTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References