Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1745653..1746266 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS07995 Protein ID WP_085160315.1
Coordinates 1745653..1746042 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS08000 Protein ID WP_085160318.1
Coordinates 1746039..1746266 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS07975 1742588..1742830 + 243 WP_163745454.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6N24_RS07980 1742812..1743099 - 288 WP_139822387.1 DUF4189 domain-containing protein -
G6N24_RS07985 1743337..1743915 - 579 WP_085160311.1 cyclic nucleotide-binding domain-containing protein -
G6N24_RS07990 1744023..1745579 - 1557 WP_085160313.1 succinate-semialdehyde dehydrogenase (NADP(+)) -
G6N24_RS07995 1745653..1746042 - 390 WP_085160315.1 PIN domain-containing protein Toxin
G6N24_RS08000 1746039..1746266 - 228 WP_085160318.1 antitoxin Antitoxin
G6N24_RS08005 1746361..1747035 - 675 WP_139822389.1 glycoside hydrolase -
G6N24_RS08010 1747019..1747324 + 306 WP_085160347.1 DUF167 domain-containing protein -
G6N24_RS08015 1747335..1748411 - 1077 WP_085160320.1 PDR/VanB family oxidoreductase -
G6N24_RS08020 1748422..1749357 - 936 WP_179963474.1 alpha/beta fold hydrolase -
G6N24_RS08025 1749377..1750285 - 909 WP_085160322.1 metal-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13876.89 Da        Isoelectric Point: 6.6037

>T36230 WP_085160315.1 NZ_AP022581:c1746042-1745653 [Mycobacterium lacus]
MIVLDASAAVELVLATGSGAAVARRLRGEALHAPAHFDVEAIGAIRRAVIRRLLSDHEGLVSVADFQSLPVRRWPTKALA
QRAYQLRHTHTVADGMYVALAEGLEAPLVTCDERLAQSHGHDADIELLA

Download         Length: 390 bp

>T36230 NZ_AP022581:c1746042-1745653 [Mycobacterium lacus]
ATGATCGTGTTGGACGCCTCGGCTGCCGTCGAGCTGGTGCTCGCGACGGGCTCGGGCGCCGCGGTCGCCCGGCGCCTGCG
CGGTGAAGCACTGCATGCCCCTGCCCATTTCGATGTGGAGGCGATCGGCGCGATACGCCGAGCGGTCATCCGCCGGCTGC
TCAGCGACCATGAAGGACTCGTCAGCGTTGCCGACTTCCAAAGCCTGCCGGTTCGGCGTTGGCCCACAAAAGCACTTGCC
CAGCGCGCCTACCAATTACGACACACTCATACCGTGGCCGACGGAATGTACGTCGCCCTCGCCGAGGGCCTCGAGGCGCC
GCTCGTCACGTGCGACGAGCGACTCGCTCAATCCCATGGCCATGACGCAGACATCGAGCTGCTTGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8255.49 Da        Isoelectric Point: 4.5535

>AT36230 WP_085160318.1 NZ_AP022581:c1746266-1746039 [Mycobacterium lacus]
MPMMVQIRNVPDELVHELKARAAAQRMSLSDFLLARLGEIAGEPTLDDVLDRLASLPRRDLGTNAAELVAEARSE

Download         Length: 228 bp

>AT36230 NZ_AP022581:c1746266-1746039 [Mycobacterium lacus]
ATGCCAATGATGGTTCAGATCCGCAATGTGCCCGATGAACTTGTCCACGAACTGAAGGCCCGAGCGGCGGCACAGCGGAT
GAGCCTCAGCGATTTCCTGCTTGCCCGGCTCGGCGAAATCGCCGGAGAGCCGACCCTCGACGACGTCCTCGACCGCCTCG
CGTCGCTGCCGCGCCGCGACCTCGGCACGAACGCCGCCGAATTGGTCGCCGAAGCCCGATCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References