Detailed information of TA system TA036229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 1513487..1514172
• Replicon: chromosome
• Accession: NZ_AP022581
• Organism: Mycobacterium lacus strain JCM 15657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N24_RS06985
• Protein ID: WP_085160862.1
• Coordinates: 1513762..1514172 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N24_RS06980
• Protein ID: WP_085160864.1
• Coordinates: 1513487..1513765 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N24_RS06965	1508542..1509030	+	489	WP_085160870.1	hypothetical protein	-
G6N24_RS06970	1509322..1509753	+	432	WP_085160868.1	SRPBCC family protein	-
G6N24_RS06975	1509896..1513420	+	3525	WP_085160866.1	DNA polymerase III subunit alpha	-
G6N24_RS06980	1513487..1513765	+	279	WP_085160864.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N24_RS06985	1513762..1514172	+	411	WP_085160862.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N24_RS06990	1514176..1516212	-	2037	WP_139822417.1	PPE family protein	-
G6N24_RS06995	1516360..1516868	-	509	Protein_1381	class I SAM-dependent methyltransferase	-
G6N24_RS07000	1516940..1518760	+	1821	WP_085160858.1	fatty acid--CoA ligase FadD11	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-46)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14712.93 Da
• Isoelectric Point: 6.2318

>T36229 WP_085160862.1 NZ_AP022581:1513762-1514172 [Mycobacterium lacus]
VIYMDTSALTKLLIAEPATPELRGWLTAQTGRGEHAATSALGRVELMRVVARYGEPGQAERARYLLDGLDILPLTETVMT
LAETIGPATLRSLDAIHLAAASRIKRELTAFVTYDHRLLDGCREVGLATASPGIDR

Nucleotide

• Length: 411 bp

>T36229 NZ_AP022581:1513762-1514172 [Mycobacterium lacus]
GTGATCTACATGGACACCTCGGCTCTGACCAAGCTGCTCATCGCCGAACCTGCGACGCCCGAACTGCGCGGCTGGCTCAC
CGCGCAAACAGGCCGGGGCGAACATGCGGCGACGAGCGCGCTCGGCCGGGTCGAGTTGATGAGAGTTGTTGCTCGCTACG
GCGAACCAGGCCAAGCCGAGCGTGCACGCTACTTACTCGACGGGCTCGACATCCTCCCGCTTACCGAAACGGTGATGACC
CTCGCTGAAACAATCGGCCCGGCTACCCTGCGTTCCCTCGACGCGATTCACCTCGCGGCCGCATCCCGGATCAAGCGGGA
ACTGACAGCGTTCGTCACATATGACCACCGGTTGTTGGACGGCTGCCGCGAGGTCGGCCTCGCGACCGCGTCGCCAGGTA
TAGACCGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10128.47 Da
• Isoelectric Point: 10.3569

>AT36229 WP_085160864.1 NZ_AP022581:1513487-1513765 [Mycobacterium lacus]
VEAIGVRELRQHASRYLARVESGEEFAITNSGRLVARLVPVHAAERSRDTLIESGTLIPARSPQNLLDLAAAPARGRKRN
LSDVLGEMRNEQ

Nucleotide

• Length: 279 bp

>AT36229 NZ_AP022581:1513487-1513765 [Mycobacterium lacus]
GTGGAGGCAATAGGAGTCCGAGAATTACGACAACACGCATCGCGATACCTCGCCCGGGTTGAATCCGGCGAGGAATTCGC
CATCACCAACAGCGGGCGGCTCGTAGCCCGACTCGTTCCTGTGCACGCGGCGGAGCGTTCTCGCGACACCCTGATCGAAT
CGGGCACGCTCATTCCTGCTCGCAGTCCACAGAACCTCCTCGATCTCGCGGCCGCACCGGCGCGGGGCCGCAAGCGCAAC
CTGTCCGATGTTCTGGGCGAGATGCGCAACGAGCAGTGA