Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1311158..1311804 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS06185 Protein ID WP_085158826.1
Coordinates 1311158..1311550 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS06190 Protein ID WP_085158828.1
Coordinates 1311547..1311804 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS06160 1306272..1307750 - 1479 WP_085158755.1 NAD(P)/FAD-dependent oxidoreductase -
G6N24_RS06165 1307747..1309147 - 1401 WP_085158757.1 cytochrome P450 -
G6N24_RS06170 1309223..1310257 + 1035 WP_085158759.1 AraC family transcriptional regulator -
G6N24_RS06175 1310347..1310727 + 381 WP_085158761.1 nucleotidyltransferase domain-containing protein -
G6N24_RS06180 1310768..1311139 + 372 WP_197743111.1 DUF86 domain-containing protein -
G6N24_RS06185 1311158..1311550 - 393 WP_085158826.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS06190 1311547..1311804 - 258 WP_085158828.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N24_RS06195 1311877..1312845 - 969 WP_085158831.1 alpha/beta hydrolase -
G6N24_RS06200 1312873..1313832 - 960 Protein_1221 alpha/beta hydrolase -
G6N24_RS06205 1313831..1314580 + 750 WP_085158833.1 lysoplasmalogenase -
G6N24_RS06210 1314636..1316660 + 2025 WP_179963472.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14398.80 Da        Isoelectric Point: 10.0535

>T36228 WP_085158826.1 NZ_AP022581:c1311550-1311158 [Mycobacterium lacus]
MILVDSDVLIAHLRGVAAARDWLVSAREDGPLAISVVSIAELIGGMRTVERREVWRLLASFRAEPVTEIIARRAGDMMRR
YRLSHNRIGLGDYLIAATADVEGLQLATLNVRHFPMLRPLQPPFATTPGT

Download         Length: 393 bp

>T36228 NZ_AP022581:c1311550-1311158 [Mycobacterium lacus]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGCCGCGGCTCGCGATTGGCTTGTCAGCGCTCG
GGAGGACGGACCCCTGGCGATCAGCGTGGTCTCGATCGCCGAACTCATTGGCGGCATGCGGACCGTCGAACGACGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGCGGAGCCGGTGACCGAGATCATCGCGCGCCGCGCCGGCGACATGATGCGCCGA
TATCGCCTCAGCCACAACCGGATTGGACTTGGCGACTATCTCATCGCCGCTACGGCCGACGTCGAGGGCCTGCAATTGGC
AACGCTCAACGTGCGGCATTTCCCTATGTTGCGGCCTTTACAACCACCGTTTGCGACGACGCCGGGGACATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9583.72 Da        Isoelectric Point: 7.0153

>AT36228 WP_085158828.1 NZ_AP022581:c1311804-1311547 [Mycobacterium lacus]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRRLLNRTLASTDSDLASDLKAINDSFGTLRDLEPPVRRSGSREEHLARV
WRATS

Download         Length: 258 bp

>AT36228 NZ_AP022581:c1311804-1311547 [Mycobacterium lacus]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTGGACAAGTTGGCCGCACAAGAAGGCGTCTCGCG
CGCCGAGTTGATCCGTCGACTGCTGAACCGCACCCTCGCCAGCACCGACAGCGATCTGGCGTCGGACCTCAAGGCGATCA
ACGATTCCTTCGGTACGCTCCGCGACCTGGAGCCGCCAGTGCGCCGCTCCGGTAGCCGCGAGGAGCACCTCGCTCGGGTG
TGGCGCGCTACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References