36227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1272311..1272951 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS06005 Protein ID WP_085159822.1
Coordinates 1272532..1272951 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS06000 Protein ID WP_085159834.1
Coordinates 1272311..1272535 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS05990 1268808..1269146 - 339 Protein_1179 transposase -
G6N24_RS05995 1269457..1272288 + 2832 WP_085159824.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
G6N24_RS06000 1272311..1272535 + 225 WP_085159834.1 antitoxin Antitoxin
G6N24_RS06005 1272532..1272951 + 420 WP_085159822.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS06010 1273802..1274749 - 948 WP_085159820.1 Lsr2 family protein -
G6N24_RS06015 1274837..1275085 + 249 WP_085159817.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
G6N24_RS06020 1275082..1275483 + 402 WP_085159815.1 PIN domain-containing protein -
G6N24_RS06025 1275748..1276668 + 921 WP_085159812.1 restriction endonuclease -
G6N24_RS06030 1276901..1277353 - 453 WP_139822360.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15038.23 Da        Isoelectric Point: 8.8986

>T36227 WP_085159822.1 NZ_AP022581:1272532-1272951 [Mycobacterium lacus]
VTALLDVNVLIALSWRNHAHHVAAREWFTRSSSSGWATTPITELGFVRISSNRRLMQVSTTPATAIAQLEALRRLPGHAF
WPDDVPLVVGEGGDRAAVSTHRIVTDRHLIALAARYGGRLLTFDAVLADAAPAGLVELL

Download         Length: 420 bp

>T36227 NZ_AP022581:1272532-1272951 [Mycobacterium lacus]
GTGACCGCACTGCTCGACGTGAATGTGCTGATCGCGTTGAGCTGGCGCAACCACGCTCACCACGTGGCGGCGCGGGAATG
GTTCACGCGGTCTTCGTCGAGTGGATGGGCCACAACGCCGATCACCGAACTGGGATTCGTTCGCATTTCGAGCAATCGCA
GGCTGATGCAGGTGTCGACGACACCGGCGACCGCTATCGCACAACTGGAGGCGCTGAGGAGGCTTCCGGGCCACGCGTTT
TGGCCCGACGACGTGCCGTTGGTGGTGGGCGAGGGTGGCGATCGCGCGGCTGTTTCGACTCACCGTATTGTTACGGACCG
TCATCTGATTGCATTGGCCGCAAGATACGGTGGCCGGCTGCTTACTTTCGACGCGGTCCTGGCCGATGCGGCACCGGCCG
GGCTCGTTGAGCTGCTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8082.02 Da        Isoelectric Point: 3.9117

>AT36227 WP_085159834.1 NZ_AP022581:1272311-1272535 [Mycobacterium lacus]
MRTTLQIDDDVLEDARDIARAEGRSVGAVISELARRSLRPVGMVEIDGFPVFDVPSDAPVITDEDVARALEEDV

Download         Length: 225 bp

>AT36227 NZ_AP022581:1272311-1272535 [Mycobacterium lacus]
ATGCGCACCACTTTGCAAATTGATGACGATGTCCTCGAAGATGCGCGTGACATCGCACGGGCGGAGGGCCGGTCGGTCGG
CGCGGTGATTTCTGAGCTGGCGCGTAGGTCGCTGCGGCCGGTCGGAATGGTCGAGATCGACGGGTTTCCGGTCTTCGACG
TTCCATCGGATGCACCGGTCATCACCGACGAAGATGTCGCCCGCGCACTCGAGGAAGATGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References