36226

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1208772..1209412 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS05695 Protein ID WP_085160455.1
Coordinates 1208772..1209194 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS05700 Protein ID WP_085160458.1
Coordinates 1209191..1209412 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS05680 1205290..1206560 + 1271 Protein_1118 protein translocase subunit SecF -
G6N24_RS05685 1206590..1208236 + 1647 WP_139822397.1 hypothetical protein -
G6N24_RS05690 1208218..1208775 + 558 WP_139822396.1 adenine phosphoribosyltransferase -
G6N24_RS05695 1208772..1209194 - 423 WP_085160455.1 PIN domain nuclease Toxin
G6N24_RS05700 1209191..1209412 - 222 WP_085160458.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N24_RS05705 1209523..1210212 + 690 WP_085160466.1 adenine phosphoribosyltransferase -
G6N24_RS05710 1210243..1212603 + 2361 WP_085160468.1 RelA/SpoT family protein -
G6N24_RS05715 1212679..1213557 - 879 WP_085160460.1 peptidylprolyl isomerase -
G6N24_RS05720 1213623..1214297 + 675 WP_085160462.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15448.65 Da        Isoelectric Point: 4.7753

>T36226 WP_085160455.1 NZ_AP022581:c1209194-1208772 [Mycobacterium lacus]
MTEQTWLIDKSALVRVPNSPDVNEWNTRIERGLVRITNLTRLEVGYSARTAAQARRDVRESPLAAMPVEYLTPAIEDRAL
EVQLLLADVGKHRGPSIPDLLIAATAELLGLTVLHADKDFEIIGELTGQPTQRLNVADVS

Download         Length: 423 bp

>T36226 NZ_AP022581:c1209194-1208772 [Mycobacterium lacus]
ATGACCGAGCAAACCTGGCTCATCGACAAATCTGCCCTGGTACGCGTTCCGAACAGCCCTGACGTCAACGAGTGGAACAC
CAGGATCGAGCGCGGCCTTGTCCGCATCACCAACCTGACGCGGCTCGAGGTCGGCTACTCAGCGCGCACCGCTGCCCAGG
CACGCCGTGACGTGCGCGAATCTCCGCTGGCCGCAATGCCTGTCGAGTATTTGACTCCGGCAATCGAGGACCGTGCCCTC
GAAGTGCAACTGCTGCTCGCTGATGTCGGCAAGCACCGGGGGCCTTCCATCCCTGATCTGCTCATAGCCGCCACGGCGGA
GCTCCTCGGCCTCACCGTGCTGCACGCGGACAAAGATTTTGAGATCATCGGCGAACTTACTGGCCAACCGACTCAGCGCC
TCAATGTCGCCGACGTGAGCTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8308.35 Da        Isoelectric Point: 7.0120

>AT36226 WP_085160458.1 NZ_AP022581:c1209412-1209191 [Mycobacterium lacus]
MSGVLIRDIPDDVLAALDRLAARLGLSRTEYIRRRLAQDARTVRTTVTAEDWRRFADTHSDLANPAVTDRAWE

Download         Length: 222 bp

>AT36226 NZ_AP022581:c1209412-1209191 [Mycobacterium lacus]
ATGAGTGGCGTACTGATCCGCGACATACCGGACGATGTGTTAGCCGCGCTGGACCGGCTTGCCGCGCGACTGGGACTCTC
CCGAACCGAATACATACGCCGCCGGCTGGCACAAGATGCACGCACAGTGAGAACGACCGTTACCGCCGAGGACTGGCGCA
GGTTCGCAGACACCCATAGCGACCTCGCCAATCCCGCGGTGACGGACCGAGCGTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References