Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1184834..1185548 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS05555 Protein ID WP_085156796.1
Coordinates 1184834..1185274 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS05560 Protein ID WP_085156793.1
Coordinates 1185261..1185548 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS05515 1180145..1180981 + 837 WP_085156819.1 acyl-CoA thioesterase II -
G6N24_RS05520 1180978..1181574 + 597 WP_085156816.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
G6N24_RS05525 1181706..1182461 + 756 WP_085156813.1 YebC/PmpR family DNA-binding transcriptional regulator -
G6N24_RS05530 1182523..1182768 + 246 WP_085156810.1 hypothetical protein -
G6N24_RS05535 1182755..1183159 + 405 WP_085156807.1 type II toxin-antitoxin system VapC family toxin -
G6N24_RS05540 1183425..1183829 + 405 WP_085156805.1 PE family protein -
G6N24_RS05545 1184025..1184318 + 294 WP_085156802.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6N24_RS05550 1184315..1184716 + 402 WP_085156799.1 PIN domain-containing protein -
G6N24_RS05555 1184834..1185274 - 441 WP_085156796.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS05560 1185261..1185548 - 288 WP_085156793.1 antitoxin Antitoxin
G6N24_RS05565 1185818..1185925 + 108 Protein_1095 PE domain-containing protein -
G6N24_RS05570 1186069..1186377 - 309 WP_085156790.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6N24_RS05575 1186364..1186609 - 246 WP_139822201.1 ribbon-helix-helix protein, CopG family -
G6N24_RS05580 1187081..1187368 + 288 WP_085156781.1 PE family protein -
G6N24_RS05585 1187526..1187762 - 237 WP_085156776.1 hypothetical protein -
G6N24_RS05590 1187801..1189369 - 1569 WP_085156773.1 polyamine aminopropyltransferase -
G6N24_RS05595 1189366..1189821 - 456 WP_085156770.1 DUF350 domain-containing protein -
G6N24_RS05600 1189846..1190277 - 432 WP_085156767.1 DUF4247 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16141.31 Da        Isoelectric Point: 5.5466

>T36223 WP_085156796.1 NZ_AP022581:c1185274-1184834 [Mycobacterium lacus]
MLLCDTNIWLALALSGHGHHSAARAWLDTIDAPAAIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNRDAWAAYAAFLDDD
RIVMAGREPDGLEAQWRRFADRQSPAPKVWMDAYLAAFAFTGGFELVTTDADFTQYSGLVVRLLTE

Download         Length: 441 bp

>T36223 NZ_AP022581:c1185274-1184834 [Mycobacterium lacus]
ATGCTGCTCTGTGACACCAACATCTGGCTCGCGTTGGCCTTGTCGGGACACGGGCACCACAGTGCCGCGCGCGCGTGGCT
GGACACGATCGATGCGCCCGCAGCCATCCATTTTTGCCGCGCAACCCAACAGTCGCTCCTGCGGCTGCTAACCAATCGGA
CCGTTCTGGGCGCATATGGCAGCCCACCACTGACCAACCGCGACGCATGGGCGGCCTATGCGGCGTTCCTCGACGACGAC
CGCATCGTGATGGCCGGTCGGGAACCCGATGGCTTGGAGGCCCAATGGAGAAGGTTCGCAGATCGCCAGTCGCCGGCACC
CAAGGTCTGGATGGATGCCTACCTGGCCGCATTCGCGTTTACCGGCGGATTCGAGTTGGTGACGACTGACGCCGACTTCA
CCCAGTACAGCGGACTCGTTGTGCGGCTCCTGACCGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10406.87 Da        Isoelectric Point: 8.0274

>AT36223 WP_085156793.1 NZ_AP022581:c1185548-1185261 [Mycobacterium lacus]
MKTTLDLPDELMRAIKVRAAQQDRKIKDVVAELLRSGLSQADSGPAARTPRRVRLPLVQCGGTATREREMTPQRVAAALL
DQEAEWSSGHDDAAL

Download         Length: 288 bp

>AT36223 NZ_AP022581:c1185548-1185261 [Mycobacterium lacus]
ATGAAAACCACGCTCGACCTGCCTGACGAACTGATGCGCGCCATCAAGGTTCGCGCGGCGCAGCAGGACCGCAAGATCAA
AGACGTCGTGGCCGAACTGCTCAGATCCGGTCTCTCCCAGGCGGACAGCGGGCCTGCGGCCCGAACACCGCGGCGCGTGC
GGCTTCCCCTGGTGCAGTGTGGCGGCACGGCCACCCGTGAACGAGAGATGACACCGCAGCGTGTGGCCGCGGCCTTGCTC
GACCAGGAGGCCGAGTGGTCATCCGGGCACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References