Detailed information of TA system TA036221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 904669..905356
• Replicon: chromosome
• Accession: NZ_AP022581
• Organism: Mycobacterium lacus strain JCM 15657

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N24_RS04275
• Protein ID: WP_085161429.1
• Coordinates: 904922..905356 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N24_RS04270
• Protein ID: WP_085161427.1
• Coordinates: 904669..904935 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N24_RS04255	900679..902370	+	1692	WP_163745409.1	transposase	-
G6N24_RS04260	902337..903440	-	1104	WP_085161430.1	magnesium/cobalt transporter CorA	-
G6N24_RS04265	903618..904607	+	990	WP_085161425.1	malate dehydrogenase	-
G6N24_RS04270	904669..904935	+	267	WP_085161427.1	antitoxin	Antitoxin
G6N24_RS04275	904922..905356	+	435	WP_085161429.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N24_RS04280	905360..906997	-	1638	WP_163745410.1	PE family protein	-
G6N24_RS04285	907112..908278	+	1167	WP_179963489.1	NADP-dependent malic enzyme	-
G6N24_RS04290	908275..909117	+	843	WP_085156717.1	hypothetical protein	-
G6N24_RS04295	909204..910037	-	834	WP_085156720.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15812.96 Da
• Isoelectric Point: 5.0587

>T36221 WP_085161429.1 NZ_AP022581:904922-905356 [Mycobacterium lacus]
VIIPDVNLLLYAVITGFPQHQRAHAWWQDTVNGPTRIGLTHPALFGFLRIATNARVLAAPVPTVDAVAYVRDWLSQPNVD
LLTAGPRHMEIALSLLEKLGTAGNLTTDVQLAAYGIENNAEIQSSDTDFARFADLRWTDPLRDG

Nucleotide

• Length: 435 bp

>T36221 NZ_AP022581:904922-905356 [Mycobacterium lacus]
GTGATCATCCCTGACGTCAATCTGCTGCTCTATGCGGTCATCACTGGGTTCCCGCAACATCAGCGCGCGCACGCGTGGTG
GCAAGATACTGTCAACGGCCCCACACGAATCGGGTTGACCCATCCAGCGTTGTTCGGATTCCTGCGGATCGCCACCAACG
CCCGAGTGCTCGCCGCGCCGGTGCCTACGGTGGATGCGGTCGCCTATGTGCGTGACTGGCTTTCGCAGCCAAACGTGGAC
CTGCTCACCGCGGGTCCGCGCCATATGGAGATCGCGTTGAGCCTGCTTGAGAAACTCGGCACCGCCGGCAACCTGACTAC
CGATGTGCAATTGGCTGCGTACGGCATCGAAAACAACGCCGAGATCCAGTCCAGTGACACCGACTTTGCCCGATTCGCCG
ACCTCAGGTGGACCGATCCCTTGCGCGACGGGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9938.15 Da
• Isoelectric Point: 5.5679

>AT36221 WP_085161427.1 NZ_AP022581:904669-904935 [Mycobacterium lacus]
MRTTLTLDDDVVRLVEEAVHRERRPMKHVINDALRSALAPQAARQEPYRLNPHESTVRPGFDLAGFNRLVDELEDAAILD
AARTGDHP

Nucleotide

• Length: 267 bp

>AT36221 NZ_AP022581:904669-904935 [Mycobacterium lacus]
ATGCGCACCACCTTGACGCTCGACGATGACGTCGTCCGCCTGGTCGAGGAGGCGGTTCATCGCGAACGCCGACCCATGAA
GCACGTCATCAACGACGCGTTGCGGAGCGCGTTGGCACCGCAGGCGGCACGCCAGGAGCCGTATCGGTTGAACCCGCATG
AGTCCACAGTGCGGCCTGGATTCGATCTGGCAGGCTTCAACCGGTTGGTCGACGAGCTGGAGGACGCGGCGATCCTGGAC
GCCGCGCGCACCGGTGATCATCCCTGA